Delayed preconditioning-mimetic actions of exercise or nitroglycerin do not affect haemodynamics and exercise performance in trained or sedentary individuals   总被引：1，自引：0，他引：1  

Crisafulli A  Melis F  Tocco F  Pittau G  Lorrai L  Gori T  Mancardi D  Concu A  Pagliaro P 《Journal of sports sciences》2007,25(12):1393-1401

Nitroglycerin induces the so-called second window of protection (SWOP), which alleviates myocardial damage and stunning after ischaemia/reperfusion. To determine whether myocardial performance during exercise is improved in the second window of protection, we studied the haemodynamic responses of 12 trained and 11 sedentary individuals during a sequence of maximal tests on a cycle ergometer. A baseline test (basal test) was followed by a second effort performed during the second window of protection (exercise-SWOP test). Haemodynamics was also evaluated after pharmacologically induced SWOP 48 h after transdermal administration of 10 mg of nitroglycerin (pharmacologically induced SWOP test). The exercise-SWOP and pharmacologically induced SWOP tests were separated by a 1-week washout period. Endothelial-dependent vasodilatation after nitroglycerin pre-treatment was also assessed in five sedentary individuals to determine whether nitrate donors could affect vascular function. We found that nitroglycerin pre-treatment did not induce any improvement in haemodynamics in either trained or sedentary individuals, since maximum values of workload, heart rate, stroke volume, cardiac output, myocardial contractility, and double product were similar between the exercise-SWOP and pharmacologically induced SWOP tests in both groups. Furthermore, nitroglycerin pre-treatment did not alter flow-mediated dilation during pharmacologically induced SWOP. Although nitroglycerin pre-treatment alleviates post-ischaemic myocardial stunning, our results suggest that it does not affect the myocardial performance of healthy individuals during exercise performed in the second window of protection, independently of the training status of the individuals. Moreover, nitroglycerin pre-treatment does not ameliorate endothelial function.  相似文献   

Extraction of Lipophilic Antioxidants from Native Tomato Using Green Technologies     

Darío R. Gmez-Linton  Arturo Navarro-Ocaa  Silvestre Alavez  Ricardo Lobato-Ortiz  Anglica Romn-Guerrero  Jos Alberto Mendoza-Espinoza  Juan Manuel Villa-Hernndez  Laura J. Prez-Flores 《Food Technology and Biotechnology》2022,60(1):121

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The use of augmented reality to improve the development of activities of daily living in students with ASD     

Lledó  Gonzalo Lorenzo  Lledó  Asunción  Gilabert-Cerdá  Alba  Lorenzo-Lledó  Alejandro 《Education and Information Technologies》2022,27(4):4865-4885

Education and Information Technologies - In today's society, technology plays a fundamental role. More and more activities of daily life are being developed with the help of technology. One of...  相似文献   

Factors Influencing Scientific Achievements of Medical Students in the Anatomy Research Group: An Analysis From the Autonomous University of Nuevo León in Mexico     

Milton Alberto Muñoz-Leija  Francisco J. Barrera  Pablo Patricio Zárate-Garza  Alejandro Quiroga-Garza  Javier Humberto Martínez-Garza  David de la Fuente-Villarreal  Santos Guzmán-López  Rodrigo Enrique Elizondo-Omaña 《Anatomical sciences education》2022,15(2):369-375

Scientific research and student involvement are critical to the formation of physicians, yet the number of medical researchers has decreased over time. To implement corrective strategies, the variables associated with positive research attitudes and productivity among medical students must be identified. The aim of this study was to evaluate the variables associated with students interested or involved in research. A validated questionnaire was applied to the student members of an established anatomy research group in a Mexican medical school with a six-year medical program. Data were collected and analyzed. A total of 85.5% (n = 77/90) students answered the survey with most respondents being second-year medical students. The majority of respondents indicated that the important component of conducting research was a contribution to the new knowledge (45.5%) and to the scientific community (42.9%). More than half of respondents mentioned a professor or a peer as the initial motivation to become involved in research. Lack of time was the main limitation (59.7%) to research involvement. Perceived benefits were knowledge and team work skills. Of those involved, most (85.7%) wished to continue participating in research as a complement to their clinical work. Professors and student colleagues were found to play an important motivational and recruitment role for medical research. These efforts in turn have developed into long-lasting mentor-mentee relationships. Students also anticipated that early involvement in research will positively influence the likelihood of future physicians' contribution and collaboration in research.  相似文献