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11.
Pek Leng NG ;Nor Fadilah RAJAB ;Sue Mian THEN ;Yasmin Anum MOHD YUSOF ;Wan Zurinah WAN NGAH ;Kar Yong PIN ;Mee Lee LOOI 《Journal of Zhejiang University. Science. B》2014,15(8):692-700
研究目的：探讨萎叶（PB）提取物对5-氟尿嘧啶（5-FU）抑制结肠癌细胞HT29和HCT116生长的影响。研究方法：HT29和HCT116细胞分别给予PB、5-FU以及两种药物联合治疗24小时,应用等效线图法分析PB和5-FU的药效学相互作用,AnnexinV／PI染色法检测HT29和HCT116细胞的凋丁L=情况,高效液相色谱法排除PB和5-FU间任何可能的相互化学作用。重要结论：联合PB,低剂量5-FU可以在短时间内起到细胞毒作用,而单独应用PB或5-FU治疗较联合治疗可以诱导更多细胞发生凋亡。进一步采用等效线图法分析显示PB和5-Fu的联合作用在抑制结肠癌细胞HT29和HCT116的生长中分别体现出协同和拮抗作用。因此可以认为在HT29细胞中,PB使得较低剂量5-FU发挥最大抑制结肠癌细胞生长效果,然而在HCT116细胞中,PB没有显著降低5-FU的药物浓度,说明PB和5-FU的相互作用不仅仅体现在诱导细胞凋亡方面。 相似文献
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Tengku Faekah Tengku Ariffin Rosna Awang Hashim Norhafezah Yusof 《Teacher Development》2014,18(2):163-176
This study was designed to examine the relationship between socialization experience and the task performance of new teachers. It proposed to do this by testing a structural model. In explicating the relationship between the two constructs, teacher engagement in workplace learning activities and wellbeing were included in the structural model as plausible mediators. The study used a survey research method to gather data from a sample of 182 beginning teachers in northern peninsular Malaysia. Data were analyzed using SPSS version 16.0 and AMOS 16.0. The findings indicate that the structural model adequately fits the data. There is a significant indirect influence of socialization factors on the task performance of new teachers, with 81% of the variance explained. 相似文献
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AbstractThe swelling discourses on organisational citizenship behaviour (OCB) have diffused into areas of management and organisational research. The existing literature encapsulates that trust will mediate the relationship between the three dimensions of organisational justice: procedural justice, distributive justice and interactional justice and OCB. Based on the literature discussions, several hypotheses were proposed and conceptual framework was formulated. A total of 411 teachers had responded and participated in the survey. The collected data were analysed using Smart Partial Least Square software. Vigorous two-stage analytical procedure was adopted. The statistical results indicated that trust significantly mediates the relationship between organisational justice and OCB as well as the dimensions of organisational justice and OCB with various degrees of mediating effects. These findings have provided new insights in the organisational behaviour discipline and shed light on trust’s mediation in the relationship of organisational justice and OCB. 相似文献
14.
Many physically active individuals have undertaken intermittent fasting to reduce their daily caloric intake. However, abstaining from meals for a specific length of time may lead to the acute disturbance of highly carbohydrate-dependent exercise performance. The purpose of this study was to observe the effect of 10 days of intermittent fasting on high-intensity type exercises, Wingate anaerobic (WT) and prolonged high-intensity time-to-exhaustion (HIT) cycling test. Twenty participants were randomised into an intermittent fasting (FAS) and a control group (CON). One day after baseline data collection on Day-0 where participants consumed their recommended daily caloric intake (FAS?=?2500?±?143?kcal?day?1; CON?=?2492?±?20?kcal?day?1) served over a course of five meals, the FAS group consumed only four meals where 40% was restricted by the omission of lunch (FAS?=?1500?±?55?kcal?day?1). This diet was then continued for 10 days. Data on exercise performance and other dependent variables were collected on Day-2, -4, -6, -8 and -10. A reduction in WT power in the FAS group was observed on Day-2 (821.74?±?66.07?W) compared to Day-0 (847.63?±?95.94?W) with a moderate effect size (p?p?p?相似文献