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Crisafulli A Melis F Tocco F Pittau G Lorrai L Gori T Mancardi D Concu A Pagliaro P 《Journal of sports sciences》2007,25(12):1393-1401
Nitroglycerin induces the so-called second window of protection (SWOP), which alleviates myocardial damage and stunning after ischaemia/reperfusion. To determine whether myocardial performance during exercise is improved in the second window of protection, we studied the haemodynamic responses of 12 trained and 11 sedentary individuals during a sequence of maximal tests on a cycle ergometer. A baseline test (basal test) was followed by a second effort performed during the second window of protection (exercise-SWOP test). Haemodynamics was also evaluated after pharmacologically induced SWOP 48 h after transdermal administration of 10 mg of nitroglycerin (pharmacologically induced SWOP test). The exercise-SWOP and pharmacologically induced SWOP tests were separated by a 1-week washout period. Endothelial-dependent vasodilatation after nitroglycerin pre-treatment was also assessed in five sedentary individuals to determine whether nitrate donors could affect vascular function. We found that nitroglycerin pre-treatment did not induce any improvement in haemodynamics in either trained or sedentary individuals, since maximum values of workload, heart rate, stroke volume, cardiac output, myocardial contractility, and double product were similar between the exercise-SWOP and pharmacologically induced SWOP tests in both groups. Furthermore, nitroglycerin pre-treatment did not alter flow-mediated dilation during pharmacologically induced SWOP. Although nitroglycerin pre-treatment alleviates post-ischaemic myocardial stunning, our results suggest that it does not affect the myocardial performance of healthy individuals during exercise performed in the second window of protection, independently of the training status of the individuals. Moreover, nitroglycerin pre-treatment does not ameliorate endothelial function. 相似文献
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Ca(OH)2 particles with submicrometric dimensions (nanolimes) are recently introduced in cultural heritage conservation, in order to improve lime treatments. Lime nanoparticles are typically produced by a chemical precipitation process in supersaturated aqueous solutions of the reactants (calcium chloride [CaCl2] and sodium hydroxide [NaOH]); water is then partially substituted with 2-propanol in order to improve stability and to reduce a random orientation of the particles. Aim of the present work is to analyse the influence of the nanolime suspensions concentration on the carbonatation process, in relation to the residual water content too. The obtained lime nanoparticles are characterised by X-rays diffraction (XRD) and profile analysis. Afterwards, the influence of the suspension concentration on stones protective treatments is evaluated: alcoholic nanolime suspensions, characterised by different concentration values, are applied on several natural lithotypes. Standard tests are performed to estimate the superficial consolidation and the protective treatment effectiveness: “Scotch tape test” (STT) and capillarity test. Porosimetric investigations are performed too. 相似文献