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Eccentric exercise has been associated with an increase in serial sarcomere number in some studies,1 but not in others.2 Similarly,increasing excursion of muscles resulted in sarcomerogenesis in some studies using growing animals,3 but not in others using skeletally mature animals.4 However,chronic elongation and chronic shortening appears to be a strong regulator of sarcomere number increase5,6 and decrease,5,7 respectively,in animal models.Despite an abundance of research on the regulation of sarcomerogenesis under a variety of conditions,the mechanisms underlying in series sarcomere number adaptations in skeletal muscles remain a puzzle,especially in non-invasive human studies where measurements of sarcomerogenesis following interventions have not been possible to date. 相似文献
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Management literature has identified high-skilled human capital as a crucial dimension of innovation processes at the firm level. In this study, we introduce an alternative view of human capital based on the tasks that firms’ workers perform. We propose a measure of cognitive analytical and interpersonal tasks: the degree of abstractism. We argue that the level of abstractism of a firm has an effect on a firm's propensity to innovate and on its product innovation performance. We hypothesize that while the degree of abstractism has a linear positive relationship with the propensity to innovate, the relationship between abstractism and product innovation performance follows an inverted u-shaped relationship. We find partial support to our hypotheses using data from more than six thousand Portuguese firms. We discuss how these results change our understanding of the relationship between human capital and innovation at the firm level. 相似文献
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Mikhail Santos Cerqueira Jose Diego Sales Do Nascimento Daniel Germano Maciel Jean Artur Mendonca Barboza Wouber Herickson De Brito Vieira 《运动与健康科学(英文)》2020,9(2):152-159
Purpose:To investigate whether blood flow restriction(BFR) without concomitant exercise mitigated strength reduction and atrophy of thigh muscles in subjects under immobilization for lower limbs.Methods:The following databases were searched:PubMed,CINAHL,PEDro,Web of Science,Central,and Scopus.Results:The search identified 3 eligible studies,and the total sample in the identified studies consisted of 38 participants.Isokinetic and isometric torque of the knee flexors and extensors was examined in 2 studies.Cross-sectional area of thigh muscles was evaluated in 1 study,and thigh girth was measured in 2 studies.The BFR protocol was 5 sets of 5 min of occlusion and 3 min of free flow,twice daily for approximately 2 weeks.As a whole,the included studies indicate that BFR without exercise is able to minimize strength reduction and muscular atrophy after immobilization.It is crucial to emphasize,however,that the included studies showed a high risk of bias,especially regarding allocation concealment,blinding of outcome assessment,intention-to-treat analyses,and group similarity at baseline.Conclusion:Although potentially useful,the high risk of bias presented by original stodies limits the indication of BFR without concomitant exercise as an effective countermeasure against strength reduction and atrophy mediated by immobilization. 相似文献
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Rebeca Fernandes Ferreira Lima Marcela Raffaelli Normanda Araujo de Morais Juliana P. Santana Carlos J. Nieto Silvia H. Koller 《Child development》2020,91(4):1237-1253
Trajectories of adjustment were examined in a sample of street-involved youth across a 1-year period. Participants (N = 113; Mage = 14.18 years; 80.5% male, 91% non-White) were recruited in three Brazilian cities. Interviews conducted at three time points included six measures of physical and psychological adjustment. Unconditional growth models revealed linear declines over time (i.e., improved adjustment) on three indicators: health symptoms, sexual risk behaviors, and negative affect. There were no linear changes in drug use, positive affect, or life satisfaction. Conditional growth models revealed few significant effects for age or gender, but ratings of stressful life events moderated longitudinal changes in health symptoms, drug use, and negative affect. Implications for practice, policy, and theory are discussed. 相似文献
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Luiz Rodrigo Augustemak de Lima Isabela de Carlos Back Everson Araújo Nunes Diego Augusto Santos Silva Edio Luiz Petroski 《Journal of sports sciences》2019,37(1):50-58
This study aimed to investigate if moderate to vigorous physical activity (MVPA) and aerobic fitness are associated with cardiovascular risk factors in HIV+ children and adolescents. Sixty-five children and adolescents (8 to 15 years) provided minutes of MVPA measured by accelerometers and peak oxygen uptake (peak VO2) by breath-by-breath respiratory exchange. Cardiovascular risk factors were characterized by body fat, blood pressure, total cholesterol, HDL-c, LDL-c, triglycerides, glucose, insulin, C-reactive protein (CRP), interleukin (IL)-6, tumor necrosis factor-alpha (TNF-α) and carotid intima-media thickness. Results indicated that higher MVPA was associated with lower values of total (β = ?3.566) and trunk body fat (β = ?3.495), total cholesterol (β = ?0.112) and LDL-c (β = ?0.830). Likewise, higher peak VO2 was associated with lower total (β = ?0.629) and trunk body fat values (β = ?0.592) and levels of CRP (β = ?0.059). The physically active participants had lower total cholesterol (?24.4 mg.dL?1) and LDL-c (?20.1 mg.dL?1) compared to participants judged to be insufficiently active. Moreover, participants with satisfactory peak VO? showed lower total (?4.1%) and trunk (?4.3%) body fat, CRP (?2.3 mg.L?1), IL-6 (?2.4 pg.mL?1) and TNF-α (?1.0 pg.mL?1) compared to low peak VO2 peers. High levels of MVPA and aerobic fitness may prevent developing of cardiovascular risk factors in children and adolescents HIV+. 相似文献
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Luiz Octávio Gavião Annibal Parracho Sant’Anna Gilson Brito Alves Lima Pauli Adriano de Almada Garcia 《Journal of sports sciences》2020,38(11-12):1221-1247
ABSTRACT The recruitment of athletes with limited resources is a global problem in professional sports. In US Major League Baseball, the experience of the Oakland Athletics’ general manager in the last decade turned his “Moneyball” model into a synonym of quantitative analysis in the transfer market of baseball players. His strategy focused on hiring players with outstanding technical skills but relatively low market value. This study adapted this model to the framework of a multiple criteria decision aid (MCDA), by selecting undervalued players who have complementary abilities. The novelty here refers to the joint use of four algorithms explored by the composition of probabilistic preferences (CPP) (i.e., ranking, classification, dynamic evaluation and regularity analysis) and their application to soccer player performance evaluation. The new model analysed the recent transfer of a left-back soccer player to Europe. The results indicated 12 opportunities for better investment, among 32 left and right-back players considered. Two years later, the value of the same player was considerably lower. He played only five matches in the 2018–2019 season, without scoring or providing any assists. On the other hand, the players better classified by the CPP-MB model presented higher performances and market values. 相似文献
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This article addresses the trajectory of Archival Science in Brazil, its extracurricular characteristics and its particular relationship with Information Science within academics, its institutional associations, and some considerations regarding current training for archivists in Brazil. The methodological procedures used included analyzing documents from the National Archive Fonds of Brazil, reviewing archive literature, and interviewing people involved in consolidating Archival Science. This study concludes that Archival Science research is taking place in graduate programs throughout public Brazilian universities and points out that people working with archives now have more advanced training, such as undergraduate degrees in Archival Science or other. This study also focuses on archives as information units, while presenting and reflecting on the demands of training archivists who are faced with the challenges of the working world and the era of information and knowledge—challenges that go beyond merely technical procedures and encompass dynamic planning and orientation activities. 相似文献
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Evdokimova Olga L. Alves Carla S. Krsmanović Whiffen Radenka M. Ortega Zaida Tomás Helena Rodrigues João 《Journal of Zhejiang University. Science. B》2021,22(6):450-461
In this study, the fibers of invasive species Agave americana L. and Ricinus communis L. were successfully used for the first time as new sources to produce cytocompatible and highly crystalline cellulose nanofibers. Cellulose nanofibers were obtained by two methods, based on either alkaline or acid hydrolysis. The morphology, chemical composition, and crystallinity of the obtained materials were characterized by scanning electron microscopy(SEM) together with energy-dispersive X-ray spectroscopy(EDX), dynamic light scattering(DLS), X-ray diffraction(XRD), and Fourier transform infrared(FTIR)spectroscopy. The crystallinity indexes(CIs) of the cellulose nanofibers extracted from A. americana and R. communis were very high(94.1% and 92.7%, respectively). Biological studies evaluating the cytotoxic effects of the prepared cellulose nanofibers on human embryonic kidney 293 T(HEK293 T) cells were also performed. The nanofibers obtained using the two different extraction methods were all shown to be cytocompatible in the concentration range assayed(i.e., 0-500 μg/mL). Our results showed that the nanocellulose extracted from A. americana and R. communis fibers has high potential as a new renewable green source of highly crystalline cellulose-based cytocompatible nanomaterials for biomedical applications. 相似文献
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Mariana Rodrigues Rita Queiroga Ana Bela Ribeiro Natália Alves Tiago Neves 《International Journal of Lifelong Education》2020,39(1):61-74
ABSTRACT Precarious jobs and unemployment have become common issues for many young adults due to the unfavourable labour market situation in Portugal. Against this background, lifelong learning (LLL) policies have been called in to play a role in creating economic growth and supporting the social inclusion of young adults in vulnerable educational and economic circumstances. These policies are defined at the national level; however, their implementation depends on the action of local actors who face specific challenges. This paper explores disparities in the definition and implementation of LLL policies targeting young adults in two Portuguese regions. Specifically, we analyse professional courses in Vale do Ave (North) and adult education and training courses in Alentejo Litoral (South). These regions were selected due to their dissimilar economic structure. This study adopted a qualitative approach through interviews with LLL experts and policy roundtables with local stakeholders and decision-makers in both regions. Data were transcribed and analysed using NVivo 10. The study shows that the two regions have different cooperation networks between local stakeholders, and that these impact the opportunities to influence the regional skills formation system differently. Also, the study shows that LLL policies are not designed to address destandardised life courses. 相似文献