Appraising research policy instrument mixes: a multicriteria mapping study in six European countries of diagnostic innovation to manage antimicrobial resistance     

Josie Coburn  Frederique Bone  Michael M. Hopkins  Andy Stirling  Jorge Mestre-Ferrandiz  Stathis Arapostathis  Martin J. Llewelyn 《Research Policy》2021,50(4):104140

This article provides prospective appraisal of key policy instruments intended to stimulate innovation to combat antimicrobial resistance (AMR). AMR refers to the ability of microbes to evolve resistance to those treatments designed to kill them, and is associated with the overuse or misuse of medicines such as antibiotics. AMR is an emerging global challenge with major implications for healthcare and society as a whole. Diagnostic tests for infectious diseases can guide decision making when prescribing medicines, so reducing inappropriate drug use. In the context of growing international interest in policies to stimulate innovation in AMR diagnostics, this study uses multicriteria mapping (MCM) to appraise a range of policy instruments in order to understand their potential performance while also highlighting the uncertainties that stakeholders hold about such interventions in complex contexts. A contribution of the article is the demonstration of a novel method to analyse and visualise MCM data in order to reveal stakeholder inclinations towards particular options while exploring interviewees’ uncertainties about the effectiveness of each instrument's design or implementation. The article reports results from six European countries (Germany, Greece, Italy, the Netherlands, Spain and the UK). The findings reveal which policy instruments are deemed most likely to perform well, and why, across stakeholder groups and national settings, with areas of common ground and difference being identified. Importantly, the conclusions presented here differ from prominent policy discourse, with international implications for the design of mixes of policy instruments to combat AMR. Strategic and practical methodological implications also emerge for general appraisal of innovation policy instrument mixes.  相似文献   

Validity of an ultra-wideband local positioning system to measure locomotion in indoor sports     

F. R. Serpiello  W. G. Hopkins  S. Barnes  J. Tavrou  G. M. Duthie  R. J. Aughey 《Journal of sports sciences》2018,36(15):1727-1733

The validity of an Ultra-wideband (UWB) positioning system was investigated during linear and change-of-direction (COD) running drills. Six recreationally-active men performed ten repetitions of four activities (walking, jogging, maximal acceleration, and 45º COD) on an indoor court. Activities were repeated twice, in the centre of the court and on the side. Participants wore a receiver tag (Clearsky T6, Catapult Sports) and two reflective markers placed on the tag to allow for comparisons with the criterion system (Vicon). Distance, mean and peak velocity, acceleration, and deceleration were assessed. Validity was assessed via percentage least-square means difference (Clearsky-Vicon) with 90% confidence interval and magnitude-based inference; typical error was expressed as within-subject standard deviation. The mean differences for distance, mean/peak speed, and mean/peak accelerations in the linear drills were in the range of 0.2–12%, with typical errors between 1.2 and 9.3%. Mean and peak deceleration had larger differences and errors between systems. In the COD drill, moderate-to-large differences were detected for the activity performed in the centre of the court, increasing to large/very large on the side. When filtered and smoothed following a similar process, the UWB-based positioning system had acceptable validity, compared to Vicon, to assess movements representative of indoor sports.  相似文献   

The effect of recovery strategies on physical performance and cumulative fatigue in competitive basketball     

Montgomery PG  Pyne DB  Hopkins WG  Dorman JC  Cook K  Minahan CL 《Journal of sports sciences》2008,26(11):1135-1145

To evaluate the effectiveness of recovery strategies on physical performance during a 3-day tournament style basketball competition, 29 male players (mean age 19.1 years, s= 2.1; height 1.84 m, s= 0.34; body mass 88.5 kg, s= 14.7) were assigned to one of three treatment groups: carbohydrate+stretching (7.7 g kg(-1) day(-1), s= 1.7; 'n = 9), cold water immersion (11 degrees C, 5 x 1; n = 10) or full leg compression garments (18 mmHg, approximately 18 h; n = 10). Effects of the recovery strategies on pre-post tournament performance tests were expressed as the mean change (% +/- standard deviation of the change score). Changes and differences were standardized for accumulated game time, assessed against the smallest worthwhile change for each test, and reported qualitatively. Accumulated fatigue was evident over the tournament with small to moderate impairments in performance tests. Sprint and agility performance decreased by 0.7% (s = 1.3) and 2.0% (s = 1.9) respectively. Vertical jump decreased substantially after the first day for all treatments, and remained suppressed post-tournament. Cold water immersion was substantially better in maintaining 20-m acceleration with only a 0.5% (s = 1.4) reduction in 20-m time after 3 days compared with a 3.2% (s = 1.6) reduction for compression. Cold water immersion (-1.4%, s = 1.7) and compression (-1.5%, s = 1.7) showed similar substantial benefits in maintaining line-drill performance over the tournament, whereas carbohydrate+stretching elicited a 0.4% (s =1.8) reduction. Sit-and-reach flexibility decreased for all groups, although cold water immersion resulted in the smallest reduction in flexibility. Basketball tournament play elicited small to moderate impairments in physical test performance. In conclusion, cold water immersion appears to promote better restoration of physical performance measures than carbohydrate + stretching routines and compression garments.  相似文献   

Discussion     

T.C. Hopkins 《Journal of The Franklin Institute》1899,147(1):1-17

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Modelling the deflection of rowing oar shafts     

Brock Laschowski  Cameron C. Hopkins  John R. de Bruyn  Volker Nolte 《Sports biomechanics / International Society of Biomechanics in Sports》2017,16(1):76-86

The deflection of rowing oar shafts subjected to a static load was investigated. Two sets of sculling oars of different design stiffness were tested at three different lengths from 2.66 to 2.70 m. Loads up to 201 N were applied to the blade end of the oar shafts, and deflections were measured at six positions along the length of the shafts. The experimental results were compared with theoretical predictions obtained by modelling the oar shafts as homogenous end-loaded cantilever beams. The results show that the oar shafts are not uniform, in contradiction to the assumed model, but rather are most compliant near the sleeves and up to 80% stiffer towards the blades. The effect of oar shaft stiffness and length on the deflection angle at the blade end of the oar shaft was at most 1.18 ± 0.01°. The measured variation of stiffness along the shaft has implications for boat propulsion and rowing performance.  相似文献   

Quiet eye predicts goaltender success in deflected ice hockey shots†     

Derek Panchuk  Joan N. Vickers  Will G. Hopkins 《European Journal of Sport Science》2017,17(1):93-99

Abstract

In interceptive timing tasks, long quiet eye (QE) durations at the release point, along with early tracking on the object, allow performers to couple their actions to the kinematics of their opponent and regulate their movements based on emergent information from the object's trajectory. We used a mobile eye tracker to record the QE of eight university-level ice hockey goaltenders of an equivalent skill level as they responded to shots that deflected off a board placed to their left or right, resulting in a trajectory with low predictability. QE behaviour was assessed using logistic regression and magnitude-based inference. We found that when QE onset occurred later in the shot (950?±?580?ms, mean?±?SD) there was an increase in the proportion of goals allowed (41% vs. 22%) compared to when QE onset occurred earlier. A shorter QE duration (1260?±?630?ms) predicted a large increase in the proportion of goals scored (38% vs. 14%). More saves occurred when QE duration (2074?±?47?ms) was longer. An earlier QE offset (2004?±?66?ms) also resulted in a large increase in the number of goals allowed (37% vs. 11%) compared to a later offset (2132?±?41?ms). Since an early, sustained QE duration contributed to a higher percentage of saves, it is important that coaches develop practice activities that challenge the goaltender's ability to fixate the puck early, as well as sustain a long QE fixation on the puck until after it is released from the stick.  相似文献   

Changes in player characteristics and match activities in Bledisloe Cup rugby union from 1972 to 2004     

Quarrie KL  Hopkins WG 《Journal of sports sciences》2007,25(8):895-903

To illustrate changes in elite rugby union match activities, we analysed coded videotape recordings of the first match in each Bledisloe Cup series played between Australia and New Zealand from 1972 to 2004. We also analysed the stature and body mass of players. Effects associated with professionalism, weather conditions, and time (expressed as change per decade) were estimated with a simple generalized linear model and standardized for interpretation of magnitude. The sample size permitted confident conclusions about effects that were of at least moderate magnitude (standardized mean difference >0.6). Increases in passes, tackles, rucks, tries, and ball-in-play time were associated with the advent of professionalism, whereas there were reductions in the numbers of lineouts, mauls, kicks in play, and in mean participation time per player. Noteworthy time trends were an increase in the number of rucks and a decrease in the number of scrums. Good weather conditions were associated with increases in tries and points scored and with reductions in the number of kicks in play and participation time per player. With the advent of professionalism, players have become heavier and backs have become taller. Overall, there have been major changes in international rugby match activities and player size over the past three decades. We believe law changes and developments in match analysis, equipment technology, and player training have contributed to the changes associated with the introduction of professionalism.  相似文献   

The association of objectively determined physical activity behavior among adolescent female friends     

Schofield L  Mummery WK  Schofield G  Hopkins W 《Research quarterly for exercise and sport》2007,78(2):9-15

The purpose of this study was to examine the extent to which physical activity among adolescent female friends is interdependent. The participants were 318 adolescent girls with a mean age of 16.0 years (range: 15-18 years). Pedometry was used to assess physical activity over 4 days. The relationship between an individual girl and her first-nominated reciprocal friend's physical activity level was moderate (r = 0.45, 90% confidence interval = 0.31, 0.56), when the friendship was nonreciprocal it was trivial (r = -.06, 90% confidence interval = -.36 .25). Friends'physical activity levels explained between 27% and 32% of an individual's pedometer-determined physical activity level. Reciprocity of friendship is an important variable to consider when understanding the relationship between adolescent female friends' physical activity. When friendships are reciprocal, there is a stronger relationship between friends' physical activity.  相似文献