When should we submit our papers? Reply to Hartley     

Shaul SHALVI  Matthijs BAAS  Michel J.J. HANDGRAAF  Carsten K.W. DE DREU 《Learned Publishing》2011,24(1):33-34

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An unsupervised heuristic-based approach for bibliographic metadata deduplication     

Eduardo N. Borges  Moisés G. de Carvalho  Renata Galante  Marcos André Gonçalves  Alberto H.F. Laender 《Information processing & management》2011

Digital libraries of scientific articles contain collections of digital objects that are usually described by bibliographic metadata records. These records can be acquired from different sources and be represented using several metadata standards. These metadata standards may be heterogeneous in both, content and structure. All of this implies that many records may be duplicated in the repository, thus affecting the quality of services, such as searching and browsing. In this article we present an approach that identifies duplicated bibliographic metadata records in an efficient and effective way. We propose similarity functions especially designed for the digital library domain and experimentally evaluate them. Our results show that the proposed functions improve the quality of metadata deduplication up to 188% compared to four different baselines. We also show that our approach achieves statistical equivalent results when compared to a state-of-the-art method for replica identification based on genetic programming, without the burden and cost of any training process.  相似文献   

Molecular Characterization of Iranian Patients with Possible Familial Hypercholesterolemia     

Farrokhi E  Shayesteh F  Asadi Mobarakeh S  Roghani Dehkordi F  Ghatreh Samani K  Hashemzadeh Chaleshtori M 《Indian journal of clinical biochemistry : IJCB》2011,26(3):244-248

Familial hypercholesterolemia (FH) is an autosomal dominant disorder of lipoprotein metabolism caused mainly by mutations in the low-density lipoprotein receptor (LDLR) and apolipoprotein B 100 (APOB) genes. Until now, the molecular basis of FH has been demonstrated in detail in many populations, but there is still very limited Molecular data concerning FH in Iran. The aim of this study was to characterize the LDLR and APOB gene mutations in an Iranian population. A total of 30 non-related Iranian possible FH subjects were studied. Diagnosis of FH was based on the Dutch Lipid Clinic Network diagnostic criteria. All samples were initially tested for three common APOB gene mutations including R3500Q, R3500 W and R3531C using PCR-RFLP assay. Subsequently, promoter and coding region of the LDLR gene was screened by PCR-SSCP analysis and positive results were confirmed by DNA sequencing. Four previously reported polymorphisms 1413G > A, 1725C > T, 1773T > C and 2140 + 5G > A were found in ~17% (5/30) of population studied. Moreover, no variation was found in APOB gene. Our data indicated that LDLR and APOB gene mutations have not contribution to possible FH in Iranian population studied here. However, we examined three common APOB mutations and LDLR in only 30 patients, and to determine the role of these genes in developing FH in Iran, more FH samples and populations needed to be investigated for the mutations of the related genes.  相似文献   

Role of Plasma MMP 9 levels in the Pathogenesis of Chronic Pancreatitis     

Venkateshwari A  Sri Manjari K  Krishnaveni D  Nallari P  Vidyasagar A  Jyothy A 《Indian journal of clinical biochemistry : IJCB》2011,26(2):136-139

Pancreatic fibrosis is a key pathological feature in the etiology of chronic pancreatitis that leads to obliteration of exocrine and endocrine pancreatic tissues and its replacement by fibrous tissue resulting in clinical manifestations. Matrix metalloproteinase 9 is a member of the MMP family that is also known as gelatinase B, degrades type IV collagen of extracellular matrix and basal membrane. The present study is aimed at evaluating the clinical significance of plasma concentration of MMP-9 in chronic pancreatitis. The samples were obtained from 112 chronic pancreatitis patients and an equal number of age and sex matched healthy controls. MMP-9 levels were quantitatively measured by ELISA assay. Statistical analysis was applied to test the significance of results. The present study revealed a significant increase of plasma MMP 9 levels in chronic pancreatitis patients compared to control subjects. Elevated levels were also observed in all the patient groups compared to control subjects with regard to sex, age, addictions etc. MMP-9 degrades the type IV collagens in normal basement membrane, which in turn activates the pancreatic stellate cells which promote the development of pancreatitic fibrosis. Thus, elevated plasma levels of MMP-9 may act as a susceptibility factor for the development of chronic pancreatitis.  相似文献   

Circulating Biomarkers and their Possible Role in Pathogenesis of Chronic Hepatitis B and C Viral Infections     

Khan S  Bhargava A  Pathak N  Maudar KK  Varshney S  Mishra PK 《Indian journal of clinical biochemistry : IJCB》2011,26(2):161-168

The present study evaluated the plausible role of circulating biomarkers in immune pathogenesis of chronic hepatitis considered a priority in clinical hepatology. Total viral load of chronic hepatitis B virus (HBV) and hepatitis C virus (HCV) patients was quantified and correlation studies were performed with circulating levels of Th1/Th2 cytokines; C reactive protein and circulating nucleosomes; glutathione reductase (GR) and superoxide dismutase. To our knowledge, the study is first among its kind that validates strong positive correlation of viral load with IL-4, IL-6, GR in HBV and IL-6, IL-10, GR in HCV infections. Although, multi-centric studies including large cohorts are required for translating our findings to clinical practice, however, role of these biomarkers with potential diagnostic or prognostic significance might be helpful in clinical assessment of high-risk individuals, thereby, designing interventional strategies, towards development of personalized medicare. The results of our study also offer valuable insights of immune signaling mediators engaged in development of hepatocellular carcinoma.  相似文献   

Mechanism of Antidiabetic Action of Compound GII Purified from Fenugreek (<Emphasis Type="Italic">Trigonella foenum graecum</Emphasis>) Seeds     

D. Puri  K. M. Prabhu  G. Dev  S. Agarwal  P. S. Murthy 《Indian journal of clinical biochemistry : IJCB》2011,26(4):335-346

To study the mechanism of action of water soluble compound GII purified from fenugreek (Trigonella foenum graecum) seeds which was shown earlier to have antidiabetic effect in the subdiabetic, moderately and severely diabetic rabbits. In rabbits (1–1.5 kg bw) diabetes was induced by intravenous injection of 80 mg/kg bw of alloxan. They were fed with GII at a dose of 50 mg/kg bw daily once in the morning for 15 days in the subdiabetic and moderately diabetic and 30 days in the severely diabetic rabbits. Serum total cholesterol (TC), triglycerides (TG), LDL + VLDL cholesterol [(LDL + VLDL)C], HDL cholesterol [(HDL)C], total tissue lipids, glycogen and enzymes of carbohydrate metabolism (glycolysis, gluconeogenesis, polyol pathway) hexokinase, glucokinase, pyruvate kinase, malic enzyme, glucose-6-phosphatase, glucose-6-phosphate dehydrogenase, aldose reductase and sorbitol dehydrogenase and antioxidant enzymes glutathione peroxidase, glutathione reductase and superoxide dismutase were estimated. Liver and kidney function parameters were also estimated. Treatment with GII for 15 days in the subdiabetic and moderately diabetic rabbits and for 30 days in the severely diabetic rabbits (i) decreased the elevated lipids TC, TG, (LDL + VLDL)C and increased the decreased (HDL)C, (ii) decreased the elevated liver and heart total lipids, TC and TG, (iii) increased the decreased liver and muscle glycogen, (iv) increased the decreased hexokinase, glucokinase, pyruvate kinase, malic enzyme, glucose-6-phosphate dehydrogenase, superoxide dismutase, glutathione peroxidase, (v) decreased the increased glucose-6-phosphatase, sorbitol dehydrogenase, aldose reductase. Results thus show that treatment with GII compound purified from fenugreek seeds for 15 days in the subdiabetic and moderately diabetic and 30 days in the severely diabetic rabbits corrects the altered serum lipids, tissue lipids, glycogen, enzymes of glycolysis, gluconeogenesis, glycogen metabolism, polyol pathway and antioxidant enzymes. Histopathological abnormalities (fatty infiltration and other cellular changes) seen in the pancreas, liver, heart and kidneys were repaired after treatment with GII. In fact partially damaged pancreas was repaired. Liver and kidney function test results were normal in the GII treated animals indicating that GII treatment is safe and free from any side effects.  相似文献   

Diagnosis of Major Organic Acidurias in Children: Two Years Experience at a Tertiary Care Centre     

M. P. Narayanan  Vaidyanathan Kannan  K. P. Vinayan  D. M. Vasudevan 《Indian journal of clinical biochemistry : IJCB》2011,26(4):347-353

Organic acid disorders are inherited metabolic disorders in which organic acids accumulate in tissues and biological fluids of affected individuals. Classical organic acidurias include methylmalonic aciduria, propionic aciduria, isovaleric aciduria and maple syrup urine disease (MSUD). They are considered the most frequent metabolic disorders among severely ill children. Patients frequently present with acute symptoms early in life. 420 cases clinically suspected to have organic aciduria, with upper age limit of 12 years for a 2-year period (January 2007–December 2008) were enrolled into this study. Metabolic acidosis and neurological symptoms were the most common signs. Screening tests and thin layer chromatography were done for detection of organic acidurias. Identification and quantitation of organic acids in urine and quantification of amino acids in blood were done by high performance liquid chromatography. Out of 420 patients, 45 patients (10.7%) were found to have organic acidurias. 15 cases of methylmalonic aciduria, 16 cases of propionic aciduria, 13 cases of MSUD, and one case of isovaleric aciduria were diagnosed. Results demonstrate the importance of testing for organic acidurias. Since organic aciduria may cause irreversible brain damage if not treated, we recommend selective screening amongst severely ill children despite implied extra costs.  相似文献   

Study of resonance-cone propagation in truncated hyperbolic metamaterial grids using transmission-line matrix simulations     

Omar F. Siddiqui  George V. Eleftheriades 《Journal of The Franklin Institute》2011,348(7):1285-1297

In this paper, we utilize transmission-line matrix simulations to study the electromagnetic properties of hyperbolic metamaterial grids, which are synthesized by arranging unloaded transmission lines over electrical ground planes, such that the unit cells are rectangular in shape. The hyperbolic grids support Bragg and Hyperbolic resonant modes that have rectangular and hyperbolic dispersion surfaces, respectively. We demonstrate the formation of these resonant modes in the hyperbolic grids and their refraction, and spatial scanning properties via circuit simulations. The simulation results are compared with experimental results of a two-layer anisotropic hyperbolic metamaterial.  相似文献   

The European university landscape: A micro characterization based on evidence from the Aquameth project   总被引：2，自引：0，他引：2  

Cinzia Daraio  Andrea BonaccorsiAldo Geuna  Benedetto LeporiLaurent Bach  Peter BogetoftMargarida F. Cardoso  Elena Castro-MartinezGustavo Crespi  Ignacio Fernandez de LucioHarold Fried  Adela Garcia-AracilAnnamaria Inzelt  Ben JongbloedGerhard Kempkes  Patrick LlerenaMireille Matt  Maria OlivaresCarsten Pohl  Tarmo RatyMaria J. Rosa  Cláudia S. SarricoLéopold Simar  Stig SlipersaeterPedro N. Teixeira  Philippe Vanden Eeckaut 《Research Policy》2011,40(1):148-164

This paper provides a new and systematic characterization of 488 universities, from 11 European countries: Finland, France, Germany, Hungary, Italy, Netherlands, Norway, Portugal, Spain, Switzerland and UK. Using micro indicators built on the integrated Aquameth database, we characterize the European university landscape according to the following dimensions: history/foundation of university, dynamics of growth, specialization pattern, subject mix, funding composition, offer profile and productivity.  相似文献   

Neutrino oscillations: The 2007 Benjamin Franklin medal in physics presented to Arthur McDonald and Yoji Totsuka     

Thomas K. Gaisser 《Journal of The Franklin Institute》2011,348(3):453-458

This award recognizes two specific discoveries that constitute the experimental discovery of neutrino oscillations. In 1998 the Super-Kamiokande group under the leadership of Yoji Totsuka published their paper, “Evidence for Oscillation of Atmospheric Neutrinos” in Physical Review Letters [1]. The paper describes a deficit of muon-type neutrinos from below the detector relative to those from above. It explains this “atmospheric neutrino anomaly” as a result of transformation of some of the muon neutrinos into another type of neutrino. Four years later, the group led by Arthur McDonald described “Direct Evidence for Neutrino Flavor Transformation from Neutral-Current Interactions in the Sudbury Neutrino Observatory” [2] in the same journal. This experiment detected lower energy neutrinos from deep inside the Sun. By measuring all flavors of neutrinos with large rates, the SNO collaboration showed definitively that the long-standing “solar neutrino puzzle” was another manifestation of neutrino oscillations. As a result of these two experiments, we now understand that neutrinos can change identities during propagation and that both the solar and atmospheric neutrino “problems” result from the same underlying phenomenon of oscillations. A consequence of neutrino oscillations is that neutrinos, previously thought to be massless, must have a non-zero rest mass.  相似文献