Production and Purification of Rabbit’s Polyclonal Antibody Against Factor VIII     

Simin Sohrabi  Azim Akbarzadeh  Dariush Norouzian  Ali Farhangi  Mehri Mortazavi  Mohammad Reza Mehrabi  Mohsen Chiani  Zahra Saffari  Soheil Ghassemi 《Indian journal of clinical biochemistry : IJCB》2011,26(4):354-359

The attempt is made to produce recombinant factor VIII but the first step in producing such product is production and purification of rabbit’s polyclonal antibody against factor VIII. The second and third steps involve monoclonal antibody and recombinant factor VIII production. Factor VIII is one of the most important coagulating factor where its deficiency leads to diseases like hemophilia type A or classic. It is an inherited disease. Previously, it was obtained through fractionation of blood plasma of blood donors. After processing, factor VIII could be used to manage such patients. Due to transfer of viral disease like hepatitis and HIV through factor VIII obtained by fractionation, high cost of production, insufficiency of the donors and the process of virus removal, thus production of factor VIII through recombinant technology can be useful and helpful. The reaction between antibody and antigen is one the most specific reaction; therefore, such reaction can be employed to identify factor VIII. Thereby, rabbits were injected several times with adjuvant-linked antigen to produce antibody. The antibody was separated from the blood sample, purified and used to identify factor VIII in the research.  相似文献   

H_∞ static output-feedback control design with constrained information for offshore wind turbine system     

Tore Bakka  Hamid Reza Karimi 《Journal of The Franklin Institute》2013

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Extracting Core ICT Indicators Using Entropy Method     

Payam Hanafizadeh  Mohammad Reza Hanafizadeh  Mohsen Khodabakhshi 《The Information Society》2013,29(4):236-247

In this article a methodology is presented to extract indicators that appropriately measure the information society and the digital divide between countries and the relevant statistics that the majority of countries can collect. With the help of content analysis, the entropy method, and consideration of the diffusion aspects of digitalization, 37 reputable information society and digital divide models are analyzed to indentify “core information and communication technology (ICT) indicators.” To overcome the limitation of the nonexistence of data, the information and the knowledge embedded in information society and digital divide models are employed as proxies for experts' opinions for extracting the core ICT indicators. Comparison of the prior indicators and the proposed ones reveals that the former ignore three important dimensions: e-learning, e-government, and networked world enablers.  相似文献   

Estimation of the range of energy flow     

F.M. Reza 《Journal of The Franklin Institute》1981,312(5):327-334

The paper relates the power engineering problem of the extremal values of effective energy flow to a well established branch of mathematics; namely, the spectral analysis of linear operators. Variation of the effective energy flow in a linear time-invariant power distribution system is studied in the light of numerical range of the operator representing the system [Eqs. (18, 19)]. A knowledge of this range and its extremal values depends on the evaluation of eigenvalues and eigenvectors of a complex network function. In most cases an exact evaluation is practically unattainable (Section V). Simple and practical estimations of the energy dissipation range are presented. The novel spectral approach to energy problems may hopefully find useful applications in power transmission and distribution.  相似文献   

Symmetry properties of tetraammine platinum(II) with C_(2v) and C_(4v) point groups     

MOGHANI Ghorban Ali  ASHRAFI Ali Reza  HAMADANIAN Masood 《Journal of Zhejiang University. Science. B》2005,(3)

INTRODUCTION The simplicity and elegance of some of theapplications of graph theory to chemistry can perhapsonly be compared with the results from group theorydealing with symmetry as a basic quality of a system.In some problems connectivity and symmetry arecombined and the question of determining symmetryproperties of graph becomes important. Given here are some definitions and notations.An automorphism of a graph G is a permutation g ofthe vertex set of G with the property that, for an…  相似文献   

Angular region: a measure of underdamped behavior     

F.M. Reza 《Journal of The Franklin Institute》1982,314(3):191-202

The natural modes of an underdamped dynamical system are given by the characteristic numbers of the quadratic operator pencil where the operator A depends on the dissipative and reactive elements of the system, while B depends solely on the reactive elements. The operator P(s) for every applied stimulus vector signal x must satisfy: A measure of underdamped behaviour is suggested by predetermining an angular region |φ| containing all natural modes of the system, When a comparison between positive operators A and B is available, say B²=KA, then The paper is motivated by Duffin-Krein-Gohberg's earlier mathematical contributions.  相似文献   

The role of intellectuals in administrative development and social change in modern Iran     

Reza Arasteh 《International Review of Education/Internationale Zeitschrift für Erziehungswissenschaft/Revue internationale l'éducation》1963,9(3):326-334

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Teacher-directed learning in view-independent face recognition with mixture of experts using single-view eigenspaces   总被引：1，自引：0，他引：1  

Reza Ebrahimpour  Ehsanollah Kabir 《Journal of The Franklin Institute》2008,345(2):87-101

We propose a new model for view-independent face recognition by multiview approach. We use the so-called “mixture of experts”, ME, in which, the problem space is divided into several subspaces for the experts, and the outputs of experts are combined by a gating network. In our model, instead of leaving the ME to partition the face space automatically, the ME is directed to adapt to a particular partitioning corresponding to predetermined views. To force an expert towards a specific view of face, in the representation layer, we provide each expert with its own eigenspace computed from the faces in the corresponding view. Furthermore, we use teacher-directed learning, TDL, in a way that according to the pose of the input training sample, only the weights of the corresponding expert are updated. The experimental results support our claim that directing the experts to a predetermined partitioning of face space improves the performance of the conventional ME for view-independent face recognition. In particular, for 1200 images of unseen intermediate views of faces from 20 subjects, the ME with single-view eigenspaces yields the average recognition rate of 80.51% in 10 trials, which is noticeably increased to 90.29% by applying the TDL method.  相似文献   

Characterization and Classification of Mesenchymal Stem Cells in Several Species Using Surface Markers for Cell Therapy Purposes     

Hori Ghaneialvar  Leila Soltani  Hamid Reza Rahmani  Abbas Sahebghadam Lotfi  Masoud Soleimani 《Indian journal of clinical biochemistry : IJCB》2018,33(1):46-52

Mesenchymal stem cells are multipotent cells capable of replicating as undifferentiated cells, and have the potential of differentiating into mesenchymal tissue lineages such as osteocytes, adipocytes and chondrocytes. Such lineages can then be used in cell therapy. The aim of present study was to characterize bone marrow derived mesenchymal stem cells in four different species, including: sheep, goat, human and mouse. Human bone-marrow mesenchymal stem cells were purchased, those of sheep and goat were isolated from fetal bone marrow, and those of mouse were collected by washing bone cavity of femur and tibia with DMEM/F12. Using flow-cytometry, they were characterized by CD surface antigens. Furthermore, cells of third passage were examined for their osteogenic and adipogenic differentiation potential by oil red and alizarin red staining respectively. According to the results, CD markers studied in the four groups of mesenchymal stem cells showed a different expression. Goat and sheep expressed CD44 and CD166, and weakly expressed CD34, CD45, CD105 and CD90. Similarly, human and mouse mesenchymal cells expressed CD44, CD166, CD105 and CD90 whereas the expression of CD34 and CD45 was negative. In conclusion, although all mesenchymal stem cells display plastic adherence and tri-lineage differentiation, not all express the same panel of surface antigens described for human mesenchymal stem cells. Additional panel of CD markers are necessary to characterize regenerative potential and possible application of these stem cells in regenerative medicine and implantology.  相似文献   

Convexity of the Energy Domain     

F.M. Reza 《Journal of The Franklin Institute》1983,315(3):179-194

A basic theorem describing the convexity of the energy domain for the general family of linear time-invariant (active or passive, reciprocal or non-reciprocal, lumped or distributed, single variable or multivariable) physical system {T} is proved.Theorem: Let F = P + jQ represent the complex energy associated with any linear physical system T (n-port). For any specified excitation of frequency s and the family of constant energy content input signals {i:∥i∥= constant}, the point F describes a convex domain in the {P;Q} plane.Part I contains a mathematical and a network theoretic proof of the foregoing theorem. In Part II the geometric nature of the energy loci for the two-ports is examined. It is shown that for all two-ports with double eigenvalves the energy domain is circular. For two-ports with distinct eigenvalves, the convex energy domain is an ellipse. The geometric characterization of this elliptic domain is examined and examples verified by computer.The concept of convexity is frequently exploited in optimization of energy in electric power system and quadratic cost functions in control theory. In this respect the central theorem of this paper, its proof and geometric ramifications should prove to be of basic interest for all linear systems.  相似文献