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Sabina Semiz Tanja Dujic Adlija Causevic 《Biochemia medica : ?asopis Hrvatskoga dru?tva medicinskih biokemi?ara / HDMB》2013,23(2):154-171
Type 2 diabetes mellitus (T2DM) is a worldwide epidemic with considerable health and economic consequences. T2DM patients are often treated with more than one drug, including oral antidiabetic drugs (OAD) and drugs used to treat diabetic complications, such as dyslipidemia and hypertension. If genetic testing could be employed to predict treatment outcome, appropriate measures could be taken to treat T2DM more efficiently. Here we provide a review of pharmacogenetic studies focused on OAD and a role of common drug-metabolizing enzymes (DME) and drug-transporters (DT) variants in therapy outcomes. For example, genetic variations of several membrane transporters, including SLC22A1/2 and SLC47A1/2 genes, are implicated in the highly variable glycemic response to metformin, a first-line drug used to treat newly diagnosed T2DM. Furthermore, cytochrome P450 (CYP) enzymes are implicated in variation of sulphonylurea and meglitinide metabolism. Additional variants related to drug target and diabetes risk genes have been also linked to interindividual differences in the efficacy and toxicity of OAD. Thus, in addition to promoting safe and cost-effective individualized diabetes treatment, pharmacogenomics has a great potential to complement current efforts to optimize treatment of diabetes and lead towards its effective and personalized care. 相似文献
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More young children and their families have access to early years services than ever before in Britain. Within these settings practitioners and parents need to work closely together for the benefit of the child. Yet the relationships within the childcare and education triangle (child, parent, practitioner) are highly complex and sometimes fraught with tension. Drawing on theories of care, the paper offers a structure for decisions about childcare and how a combination of expectations from parents and practitioners regarding everyday care practice can either be the basis of a trusting relationship between the adults involved in this caring triangle or a breeding‐ground for tensions. The study is mainly based on qualitative research from a study combining qualitative and quantitative methods with family day care providers in the north‐east of England and the north‐east of Germany. 相似文献
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Intergenerational transmission of gender segregation: How parents’ occupational field affects gender differences in field of study choices 
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下载免费PDF全文 Maaike van der Vleuten Eva Jaspers Ineke Maas Tanja van der Lippe 《British Educational Research Journal》2018,44(2):294-318
The study explores how parents’ occupational field affects gender differences in educational fields. On the one hand, the theory of direct transfer predicts that adolescents enter fields similar to those of their parents because of intergenerational transmission of occupation‐specific resources and that adolescents are more likely to draw upon the resources provided by the higher‐status parent. On the other hand, the theory of sex‐role learning predicts that boys and girls are more likely to choose more gender‐stereotypical fields of study because they learn ‘appropriate’ gender‐role behaviour from their parents’ occupational field and that boys are more likely to learn this behaviour from their father and girls from their mother. We use longitudinal data collected from adolescents and their parents in the Netherlands (N = 2,497) and tested our hypotheses using multiple‐group structural equation modelling and multinomial regression analyses. In line with sex‐role learning, results show that especially mothers who are employed in a more feminine occupational field influence their daughters to enter a more feminine field of study (health, biology, agriculture and veterinary) and their sons to enter a more masculine field of study (science and technology). Mothers’ occupational field therefore not only influences girls’ field of study, but also boys’. This study highlights the role of horizontal characteristics when examining which field of study adolescents enter. Contrary to the stratification literature, which primarily focuses on fathers, this study concludes that mothers play a more important role in gender differences in fields of study. 相似文献
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Peter Kelly Ulrike Hohmann Nick Pratt Hans Dorf 《British Educational Research Journal》2013,39(4):609-634
Within the context of lower secondary English teaching in South West England, this study identifies in broad terms the competing goals between which English teachers mediate and the explicit and hidden tensions that result. To understand the interactions of competing goals, teachers' goal‐oriented behaviours are referenced to a set of idealised ‘role types’ based on the dimensions of goals, norms, discourses and practices. It is asserted that competing goals, significant to particular educational circumstances, emanate from various sometimes contradictory local, national and perhaps broader social and cultural influences on practice. Yet the teachers observed moved smoothly between goal‐oriented behaviours in a continuous and comfortable style, easily and without reflecting any tensions between them. Thus, this article elaborates an account of situated English teaching. 相似文献
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This article examines both the discourses upon which Finnish special needs education professors draw when speaking about their field, and the consequent identities for it. The research material consists of theme interviews with 10 professors of special needs education and is analysed from a socio-constructionist, discourse analytical perspective. The results show that the professors defined special needs education from two separate viewpoints: on the basis of their own personal views, or on the basis of the classical definitions of special needs education. The professors spoke about the field through five different discourses: professional, emancipatory, relativistic, autonomous and critical. The majority of these discourses constructed special needs education as an important part of the science field, although the relativistic discourse problematised its position as an independent discipline. 相似文献
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The aim of the present study was to gather information from athletes and doping control officials about their satisfaction and acceptance concerning the accomplishment of the doping control system (DCS) in Germany. 761 high elite athletes and 101 doping control officers took part in a written survey. Special attention was given to the subjective estimation of knowledge about the DCS as well as to their experiences during doping controls (DC) and on the whereabouts system.Three quarters of the responding athletes stated to have control experience; many of them were controlled several times a year. The majority of athletes confirmed to be familiar with the sampling procedure. But every second mentioned deficits regarding their rights during the collection or the functioning of the whereabouts system. Athletes and control officials evaluated their communication and coordination among each other mainly positive. By the majority of athletes, control officials’ attitude was judged to be friendly and open minded and their behavior neutral and discreet. A strong and internationally comparable accomplishment of the DCS was demanded especially from athletes belonging to higher testing pools. Doping control officials appreciated athletes’ generally high willingness to cooperate and, predominantly, felt well instructed for their duty. 相似文献
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Efficiency differences of finnish senior secondary schools: An application of DEA and Tobit analysis 总被引：1，自引：0，他引：1
We studied efficiency differences among Finnish senior secondary schools by Data Envelopment Analysis (DEA). Four model variants were used. Average efficiencies in the most extensive models were 82–84 per cent. When parents' educational level was treated as an additional input, average efficiency increased to 91 per cent. The efficiency rankings of schools changed to some extent when simplest quantitative inputs and outputs were augmented by measures of teacher quality and national matriculation examination results. As a second stage after DEA analysis, we explained the degree of inefficiency (100-efficiency score) by a statistical Tobit model. Schools with small classes and heterogenous student bodies were inefficient whereas school size did not affect efficiency. Surprisingly, private schools were inefficient relative to public schools. When parents' educational level was only included in the Tobit model, it affected efficiency positively. 相似文献
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