Low-intensity pulsed ultrasound ameliorates angiotensin II-induced cardiac fibrosis by alleviating inflammation via a caveolin-1-dependent pathway     

Zhao  Kun  Zhang  Jing  Xu  Tianhua  Yang  Chuanxi  Weng  Liqing  Wu  Tingting  Wu  Xiaoguang  Miao  Jiaming  Guo  Xiasheng  Tu  Juan  Zhang  Dong  Zhou  Bin  Sun  Wei  Kong  Xiangqing 《Journal of Zhejiang University. Science. B》2021,22(10):818-838

Journal of Zhejiang University-SCIENCE B - Objective: Cardiac hypertrophy and fibrosis are major pathological manifestations observed in left ventricular remodeling induced by angiotensin II...  相似文献   

农村初中化学新课程教学的探索与实践     

翁家群 《陕西广播电视大学学报》2005,7(4):74-75

本文就农村初中化学新课程教学面对的困难,以及怎样克服困难有效实施并推进新课程教学可以采取的措施进行了阐述。  相似文献   

面向终身教育的高等工程教育:矛盾与协调   总被引：3，自引：1，他引：3  

李开玲  郭桂英 《高等工程教育研究》2006,(3):26-29

从终身教育以观中国的高等工程教育,尚存主体意识、教育目标、蓝图设计方面的种种不足。终身教育的统整性、内涵的丰富性等给高等工程教育以丰富的启迪。高等工程教育应在通才与专才、目的与手段、学与术、模式的单一还是多样、传统与创新、科学与人文的矛盾上致力于协调与转换,自觉地把自己纳入终身教育体系,培养出时代呼唤的工程人才。  相似文献   

Content subscribing mechanism in P2P streaming based on gamma distribution prediction     

GUO Tong-qiang WENG Jian-guang ZHUANG Yue-ting 《浙江大学学报(A卷英文版)》2007,8(12):1983-1989

P2P systems are categorized into tree-based and mesh-based systems according to their topologies. Mesh-based systems are considered more suitable for large-scale Internet applications, but require optimization on latency issue. This paper proposes a content subscribing mechanism (CSM) to eliminate unnecessary time delays during data relaying. A node can send content data to its neighbors as soon as it receives the data segment. No additional time is taken during the interactive stages prior to data segment transmission of streaming content. CSM consists of three steps. First, every node records its historical segments latency, and adopts gamma distribution, which possesses powerful expression ability, to express latency statistics. Second, a node predicts subscribing success ratio of every neighbor by comparing the gamma distribution parameters of the node and its neighbors before selecting a neighbor node to subscribe a data segment. The above steps would not increase latency as they are executed before the data segments are ready at the neighbor nodes. Finally, the node, which was subscribed to, sends the subscribed data segment to the subscriber immediately when it has the data segment. Experiments show that CSM significantly reduces the content data transmission latency.  相似文献   

浅谈信息化社会环境下高校图书馆的服务理念   总被引：2，自引：0，他引：2  

温晓玲 《山西广播电视大学学报》2008,13(1):81-83

在信息化和市场经济日益完善的社会中,高校图书馆应具有目标创新、服务创新和角色创新,高校图书馆要利用自身优势,立足于满意服务向知识服务方面转化,给广大师生读者更好、更高水平知识服务,探讨在信息化社会环境下,高校图书馆的作用、服务质量、服务理念尤为重要.  相似文献   

党的思想路线丰富和发展的内在逻辑     

黄桂英  田克勤 《思想理论教育导刊》2008,1(2):32-36

从毛泽东到邓小平再到江泽民、胡锦涛,党对思想路线的认识和把握不断深化。党的思想路线的不断丰富和发展体现了主观与客观相符合、理论与实际相联系、历史与现实相统一的基本立场、观点和方法。这些基本原则、方针和方法,构成了党的思想路线丰富和发展的内在动力,是党的思想路线不断丰富和发展的内在逻辑。  相似文献   

Wind suitability in site analysis of coastal concave terrains using computational fluid dynamics simulation: a case study in East Asia     

Xiao-qing Zhu  Jian-tao Weng  Yi-qun Wu  Wei-jun Gao  Zhu Wang 《浙江大学学报(A卷英文版)》2017,18(9):741-756

The effect of wind environment is becoming increasingly important in analyzing and selecting sites for better natural ventilation of residential buildings, external comfort, and pollution dispersion. The main purpose of this study was to develop a set of methods for wind environment assessment in coastal concave terrains. This set of methods can be used to provide quantifiable indicators of preferable wind conditions and help site analysis. Firstly, a total of 20 types of coastal bays with concave terrains in East Asia were characterized to find ideal locations. The selected areas were divided into five categories according to the main terrain features. Then a sample database for the concave terrains was compiled for modelling comparisons. Secondly, a number of key wind variables were identified. Computational fluid dynamics (CFD) models of the typical coastal concave terrains identified as a result of the study were created, and the local wind environments were simulated with input from geographic information system (GIS) and statistic package for social science (SPSS) analysis. A measure of wind suitability was proposed that takes wind velocity and wind direction into account using GIS. Finally, SPSS was used to find the relationship between wind suitability and key terrain factors. The results showed that wind suitability was significantly associated with terrain factors, especially altitude. The results suggest that residential building sites should be selected such that their bay openings face the direction of the prevailing wind and that the opposite direction should be avoided.  相似文献   

试论旅游管理硕士研究生的培养     

翁钢民 《教学研究(河北)》2003,26(4):315-317

本从旅游业和旅游管理学科的特点出发，探讨了旅游管理硕士研究生的培养目标，结合培养目标论述了旅游管理研究生的教学模式和课程设置，并提出了提高研究生培养质量的实施对策。  相似文献   

Colored wax-printed timers for two-dimensional and three-dimensional assays on paper-based devices     

Chen-Hsun Weng  Ming-Yi Chen  Chi-Hsiang Shen  Ruey-Jen Yang 《Biomicrofluidics》2014,8(6)

Microfluidic paper-based analytical devices (μPADs) are widely used for performing diagnostic assays. However, in many assays, time-delay valves are required to improve the sensitivity and specificity of the results. Accordingly, this study presents a simple, low-cost method for realizing time-delay valves using a color wax printing process. In the proposed approach, the time-delay effect is controlled through a careful selection of both the color and the saturation of the wax content. The validity of the proposed method is demonstrated by performing nitrite and oxalate assays using both a simple two-dimensional μPAD and a three-dimensional μPAD incorporating a colored wax-printed timer. The experimental results confirm that the flow time can be controlled through an appropriate selection of the color and the wax content. In addition, it is shown that nitrite and oxalate assays can be performed simultaneously on a single device. In general, the results presented in this study show that the proposed μPADs provide a feasible low-cost alternative to conventional methods for performing diagnostic assays.  相似文献   

Single cell kinase signaling assay using pinched flow coupled droplet microfluidics     

Ramesh Ramji  Ming Wang  Ali Asgar S. Bhagat  Daniel Tan Shao Weng  Nitish V. Thakor  Chwee Teck Lim  Chia-Hung Chen 《Biomicrofluidics》2014,8(3)

Droplet-based microfluidics has shown potential in high throughput single cell assays by encapsulating individual cells in water-in-oil emulsions. Ordering cells in a micro-channel is necessary to encapsulate individual cells into droplets further enhancing the assay efficiency. This is typically limited due to the difficulty of preparing high-density cell solutions and maintaining them without cell aggregation in long channels (>5 cm). In this study, we developed a short pinched flow channel (5 mm) to separate cell aggregates and to form a uniform cell distribution in a droplet-generating platform that encapsulated single cells with >55% encapsulation efficiency beating Poisson encapsulation statistics. Using this platform and commercially available Sox substrates (8-hydroxy-5-(N,N-dimethylsulfonamido)-2-methylquinoline), we have demonstrated a high throughput dynamic single cell signaling assay to measure the activity of receptor tyrosine kinases (RTKs) in lung cancer cells triggered by cell surface ligand binding. The phosphorylation of the substrates resulted in fluorescent emission, showing a sigmoidal increase over a 12 h period. The result exhibited a heterogeneous signaling rate in individual cells and showed various levels of drug resistance when treated with the tyrosine kinase inhibitor, gefitinib.  相似文献