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51.
Emmanuel J Favaloro Giuseppe Lippi 《Biochemia medica : ?asopis Hrvatskoga dru?tva medicinskih biokemi?ara / HDMB》2012,22(3):329-341
The tests currently employed within most haemostasis laboratories to monitor anticoagulant therapy largely comprise the prothrombin time (PT)/ International Normalised Ratio (INR) and the activated partial thromboplastin time (APTT). These are respectively used to monitor Vitamin K antagonists (VKAs) such as warfarin, and unfractionated heparin. Additional tests that laboratories may also employ for assessing or monitoring unfractionated heparin include thrombin time (TT) and the anti-Xa assay, which can also be used to monitor low molecular weight heparin. Several new anti-thrombotic agents have recently emerged, or are in the final process of clinical evaluation. These novel drugs that include Dabigatran etexilate and Rivaroxaban would not theoretically require monitoring; however, testing is useful in specific situations. The tests currently used to monitor VKAs and heparin are typically either too sensitive or too insensitive to the new drugs to be used as ‘typically performed in laboratories’, and may thus require some methodological adjustments to increase or decrease their sensitivity. Alternately, different tests may be better employed in these assessments. Whatever the case, laboratories may soon be performing a reduced or possibly increased number of tests, the same kind of tests but perhaps differently, or conceivably different assay panels. Specific laboratory guidance on the choice of the appropriate test to be ordered according to the drug being administered, as well as on appropriate interpretation of test results, will also be necessary. The current report reviews the current state of play and provides a glimpse to the possible future of the coagulation laboratory. 相似文献
52.
Lippi G Cervellin G Aloe R Montagnana M Salvagno GL Guidi GC 《Biochemia medica : ?asopis Hrvatskoga dru?tva medicinskih biokemi?ara / HDMB》2012,22(1):127-129
Introduction:
The measurement of cardiospecific troponins is pivotal in the diagnostic and prognostic approach of patients with suspected acute myocardial infarction (AMI). However, no information is available on the commutability of results between the novel highly-sensitive (HS) troponin T (TnT) and I (TnI) immunoassays.Materials and methods:
The study population consisted in 47 consecutive patients presenting at the emergency department (ED) of the Academic Hospital of Parma with suspected AMI. TnI was measured with the novel prototype Beckman Coulter HS-AccuTnI immunoassay on Access 2, whereas TnT was measured with the Roche HS-TnT immunoassay on Cobas.Results:
Eight out of the 47 patients (17%) were finally diagnosed as having an AMI. The overall correlation between TnT and TnI for total patient group was acceptable (r = 0.944; P < 0.01). Nevertheless, when the analysis of data was carried out in separate groups according to the final diagnosis of AMI, two different equation results were obtained, i.e., HS-TnT = HS-AccuTnI × 0.349 + 20 (r = 0.823; P < 0.01) in non-AMI patients, and HS-TnT = HS-AccuTnI × 0.134 + 67 (r = 0.972; P < 0.01) in those with AMI.Conclusions:
This study suggests the existence of two biological relationships between TnI and TnT in plasma, depending on the source of release from the myocardium. Moreover, the non-commutability of data between HS-TnT and HS-AccuTnI jeopardizes the clinical decision making, makes it impossible to calculate the delta or reference change value using the two biomarkers and to finally establish a reliable kinetics of troponin release from the injured myocardium. 相似文献53.
Giuseppe Coratella Stefano Longo Emiliano Cè Eloisa Limonta Susanna Rampichini Angela Valentina Bisconti 《Research quarterly for exercise and sport》2018,89(3):347-353
Purpose: The present study aimed to investigate whether or not eccentric-only training induced different sex-related adaptations in vastus lateralis muscle architecture and knee extensors strength. Methods: Thirteen healthy women and 13 healthy men were recruited. Vastus lateralis pennation angle, fascicle length, and muscle thickness, as well as knee extensors eccentric, isometric, and concentric peak torque and one-repetition maximum (1RM) were measured. Both women and men underwent a unilateral iso-load knee-extension eccentric-only training with 120% of the concentric 1RM, consisting of 4 sets × 10 repetitions twice a week for a total of 8 weeks. Results: Pennation angle increased in women (+ 14%, 95% CI [10, 17], effect size [ES] = 1.54) but not in men (+ 5%, 95% CI [?1, 11], ES = 0.28), while fascicle length increased in both women (+ 7%, 95% CI [4, 10], ES = 1.02) and men (+ 12%, 95% CI [8, 16], ES = 1.82) and muscle thickness increased in women (+ 13%, 95% CI [8, 18], ES = 1.11) and men (+ 11%, 95% CI [7, 15], ES = 0.89). In both women and men, eccentric (18%, 95% CI [11, 25], ES = 0.96, and 16%, 95% CI [9, 22], ES = 0.82, respectively), isometric (17%, 95% CI [11, 23], ES = 0.53, and 17%, 95% CI [10, 24], ES = 0.62), concentric (12%, 95% CI [7, 16], ES = 0.49, and 9%, 95% CI [5, 13], ES = 0.42) peak torque and 1RM (10%, 95% CI [6, 14], ES = 0.53, and 10%, 95% CI [5, 15], ES = 0.50) similarly increased after the intervention. Conclusions: This study showed that the adaptations in strength are not sex-dependent, but the increases in pennation angle only in women suggest that the changes in muscle architecture may depend on sex. 相似文献
54.
The aim of this paper is to illustrate the phenomenon of corporate universities from the perspective of the evaluation of their performance. Corporate universities have a hybrid nature that can be referred to both as a business unit and as a higher education institution. Having reviewed the literature on corporate universities and performance evaluation of these kind of entities, we present the results of a survey on Italian corporate universities. Results shows that an appropriate framework for the evaluation of corporate university performance need to distinguish among the different types of corporate universities that are actually in place according to their mission and degree of openness to the external environment. 相似文献
55.
The primary purpose of this study lies in the evaluation of what students acquire from studies abroad in the context of credit mobility, in terms of competence development and personal growth, compared with that gained by students completing their study or internship in their home country. A pre-post test design, with both an experimental group and a control group, was employed for students participating in the Erasmus programme and those continuing their regular course of study at their home university. The findings obtained suggest that study abroad programmes have a positive impact on the perception of university students. The highest values among Erasmus students in terms of outcomes were attributed to cultural enhancement, personal development and foreign language proficiency. Study abroad has, furthermore, a Europeanising impact inasmuch as it affects the self-identity of students. 相似文献
56.
Gabriel Lima-Oliveira Giuseppe Lippi Gian Luca Salvagno Giorgio Brocco Gian Cesare Guidi 《Biochemia medica : ?asopis Hrvatskoga dru?tva medicinskih biokemi?ara / HDMB》2015,25(2):273-278
Introduction
In vitro human diagnostic (IVD) company recalls are a common practice aimed to either minimize a potential error or eliminate an existing failure. In this case report, we aim to provide a critical analysis of a recent IVD recall and to provide a practical framework about what to do when an IVD company recalls product(s) based on the International Organization for Standardization - ISO 15189:2012 standard.Case report
In 2014, Abbott Laboratories® (Green Oaks, IL) published an urgent field safety notice regarding a product recall (Architect Intact parathyroid hormone (PTH) Assay List Number 8K25) with immediate action required. The IVD company explained the reasons for the recall as follows: i) Abbott has confirmed that a performance shift in the Architect Intact PTH assay has the potential to generate falsely elevated results on patient samples; ii) results generated with impacted lots may demonstrate a positive shift relative to those generated with previous reagent and/or calibrator lots. This issue may also impact established Architect Intact PTH reference ranges; iii) the magnitude of shift averages approximately 13% to 45%; iv) Abbott Architect Intact PTH controls do not detect the shift; and v) all current reagent, calibrator, and control inventory are impacted. The recall could have resulted in ~40,000 inaccurate laboratory tests reported by 18 laboratories from Italy (Lombardy region).Conclusion
IVD company recalls have a serious impact on the patient safety and require a thorough investigation and responsible approach to minimize the possible damage. Medical laboratories accredited according to the ISO 15189 standard have procedures in place to manage such situations and ensure that patient safety is maintained when such recalls are issued.Key words: clinical laboratory techniques, patient safety, laboratory variability, reference standards, quality control, parathyroid hormone 相似文献57.
Leon Derczynski Diana Maynard Giuseppe Rizzo Marieke van Erp Genevieve Gorrell Raphaël Troncy Johann Petrak Kalina Bontcheva 《Information processing & management》2015
Applying natural language processing for mining and intelligent information access to tweets (a form of microblog) is a challenging, emerging research area. Unlike carefully authored news text and other longer content, tweets pose a number of new challenges, due to their short, noisy, context-dependent, and dynamic nature. Information extraction from tweets is typically performed in a pipeline, comprising consecutive stages of language identification, tokenisation, part-of-speech tagging, named entity recognition and entity disambiguation (e.g. with respect to DBpedia). In this work, we describe a new Twitter entity disambiguation dataset, and conduct an empirical analysis of named entity recognition and disambiguation, investigating how robust a number of state-of-the-art systems are on such noisy texts, what the main sources of error are, and which problems should be further investigated to improve the state of the art. 相似文献
58.
The TEMAS (acronym for Tell‐Me‐a‐Story)—an objectively scored, projective thematic personality instrument for children and adolescents—is analyzed, reviewed, and critiqued with regard to theoretical underpinnings and rationale for development, administration, scoring, psychometric properties, and research to date. The TEMAS appears to be an improvement over existing projective personality measures used by school psychologists. Although it requires more training than other projective techniques, competency in administration, scoring, and interpretation can be achieved within a one semester course in personality assessment. The test has evidence of reliability and validity, and it is a multicultural alternative to the TAT and other thematic apperception instruments. The use of the TEMAS by psychologists may achieve more accurate assessment of Black and Hispanic children. Limitations include geographically limited standardization samples and little research conducted by individuals other than the authors. © 1999 John Wiley & Sons, Inc. 相似文献
59.
Dan Wang Giuseppe De Vito Massimiliano Ditroilo Eamonn Delahunt 《Journal of sports sciences》2017,35(16):1582-1591
The purpose of this study was to investigate the influence of sex and fatigue on knee extensor peak torque (PT), muscle stiffness (MS) of the vastus lateralis (VL) and knee joint musculoarticular stiffness (MAS) in young adults. Twenty-two male and 22 female recreational athletes participated. Males were characterised by higher relaxed [pre-: males 364.43 (52.00) N · m–1, females 270.27 (37.25) N · m–1; post-: males 446.75 (83.27) N · m–1, females 307.39 (38.58) N · m–1] and contracted [pre-: males 495.07 (71.04) N · m–1, females 332.34 (85.42) N · m–1; post-: males 546.37 (90.74) N · m–1, females 349.21 (85.55) N · m–1] MS of the VL, and knee joint MAS [pre-: males 1450.11 (507.98) N · m–1, females 1027.99 (227.33) N · m–1; post-: males 1345.81 (404.90) N · m–1, females 952.78 (192.38) N · m–1] than females pre- and post-fatigue. A similar finding was observed in pre-fatigue normalised knee extensor PT [pre-: males 2.77 (0.42) N · m kg–1, females 2.41 (0.40) N · m kg–1, post-: males 2.53 (0.54) N · m kg–1, females 2.26 (0.44) N · m kg–1]. After the fatigue protocol, normalised knee extensor PT and knee joint MAS decreased, whilst relaxed and contracted MS of the VL increased in both sexes. These observed differences may contribute to the higher risk of knee injury in females and following the onset of fatigue. 相似文献
60.
Bruno Calderoni Giuseppe Cecere Emilia Angela Cordasco Luigi Guerriero Pietro Lenza Gaetano Manfredi 《Journal of Cultural Heritage》2010,11(2):163-171
The knowledge of the morphological and mechanical properties of masonry walls is very important for the refurbishment of ancient buildings, particularly when the requirements of both structural safety and historical preservation must be fulfilled. The masonry is not of homogenous material: its mechanical properties depend on stones, mortar, and texture which are very variable due to their dependence on the historical periods and the geographical area of the erection. For this reason, a deep knowledge of masonries built in different sites and historical periods is essential in order to evaluate both the capacities of bearing vertical load and the seismic vulnerability of the masonry structure. Three fundamental typologies of tuff masonry have been defined: they are the characteristics of different historical periods from the XVI to the XX century. The models are in full-scale in order to reproduce the three defined chronotypes. Original tuff stones quarried in the corresponding historical period, mortars similar to the original ones, reproduced according to ancient documents and original constructive techniques have been used for the construction of the specimens. Compression tests performed in displacement control have been carried out on the masonry models in order to determine the maximum resistance of the material and the corresponding strain, the ultimate strain and corresponding residual strength. In this paper, the procedure used for making the specimens and for experimentally evaluating the mechanical properties of post-medieval Neapolitan yellow tuff masonry are illustrated and the obtained results, even in terms of plastic capacity of these kinds of masonry, are reported. 相似文献