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31.
M Geraldine V Justin U Sheila T Venkatesh 《Indian journal of clinical biochemistry : IJCB》2001,16(2):211-212
Alkaline haemoglobin electrophoresis is a useful tool in diagnosing β-thalassemia and sickle-cell anaemia. In this report,
using this simple technique, β-thalassemia associated with sickle-cell anaemia is diagnosed. This is the first case we have
diagnosed in our laboratory using agarose gel electrophoresis. 相似文献
32.
Herman S. Dsouza Geraldine Menezes T Venkatesh M.Sc. Ph.D. FACBI. FINASS 《Indian journal of clinical biochemistry : IJCB》2002,17(1):9-11
It is well known that lead exposure in the early period of pre pregnancy and antenatal life leads to serious health complications. In this case report, a five month old child who was suffering from encephalopathy was finally confirmed a victim of lead exposure, the source being the environment and the family. We report this case with complete clinical investigation including blood lead analysis. This case report highlights the various ways in which lead may accumulate in the body. It is also aimed at increasing awareness regarding the pathogenesis and clinical manifestations of lead toxicity. The literature survey done reveals that this is the youngest age at which lead toxicity has been documented in India. 相似文献
33.
S. Jaya Kumari Nivedita Jayaram Lloyd Vincent T. Venkatesh 《Indian journal of clinical biochemistry : IJCB》2002,17(1):45-48
Type 2 diabetes is associated with a marked increase in the risk of coronary artery disease. Dyslipidaemia is believed to
be a major cause of this increased risk. Recently, elevated levels of lipoprotein (a), Lp(a), have been reported to be associated
with an increased risk. However there is very little data regarding Lp(a) concentrations and type 2 diabetes from India. The
objective of the study was to assess serum Lp(a) levels in type 2 diabetics with and with out evidence of clinical nephropathy.
We estimated serum Lp(a) levels in 30 control subjects, 30 diabetics without evidence of clinical nephropathy and 30 diabetics
with evidence of clinical nephropathy. Statistical analysis showed that Lp(a) levels were increased in diabetic patients with
nephropathy (mean 46.3±17.6 mg/dl). The Lp(a) levels however did not differ significantly between control (mean 20.2±15.9
mg/dl) and diabetics without nephropathy (mean 22.6±13.1mg/dl). Thus diabetes per se seems to have little or no influence
on serum Lp(a) levels, however elevated levels were seen in patients with nephropathy. 相似文献
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Fifty patients were evaluated for serum total PSA (Prostate Specific Antigen), free PSA (f-PSA), free/total PSA ratio (f/t
PSA ratio) and TPSTM (Tissue Polypeptide Specific Antigen). Fifty patients were clinically evaluated and categorized into BPH (benign prostatic
hypertrophy) and CaP (carcinoma prostate) with twenty-five in each category before the serological examination. Serum total
PSA concentration is elevated in 80% of BPH cases while it was elevated in all cases of CaP. With total PSA>10ng/mL, f/t PSA
ratio was not applicable. For TPSTM, a cell proliferation marker these values were 32% and 92% respectively. The advanced cases of CaP were reflected by the
pronounced elevations of PSA and TPStM while f/t PSA ratio was much below the cut-off limit (cut-off limit=0.14). The data suggest that whentotal PSA concentration
<10ng/mL, f/t PSA ratio plays a very important role in discriminating BPH and CaP. However, TPSTM can be used as a valuable adjunct in diagnosis and follow-up of prostate cancer patients, especially in differentiating benign
from malignant cases. 相似文献
36.
Noetica is a tool for structuring knowledge about concepts and the relationships between them. It differs from typical information systems in that the knowledge it represents is abstract, highly connected and includes meta-knowledge (knowledge about knowledge). Noetica represents knowledge using a strongly-typed semantic network. By providing a rich type system it is possible to represent conceptual information using formalised structures. A class hierarchy provides a basic classification for all objects. This allows for a consistency of representation that is not often found in “free” semantic networks and gives the ability to easily extend a knowledge model while retaining its semantics. We also provide visualisation and query tools for this data model. Visualisation can be used to explore complete sets of link-classes, show paths while navigating through the database, or visualise the results of queries. Noetica supports goal-directed queries (a series of user-supplied goals that the system attempts to satisfy in sequence) and path-finding queries (where the system find relationships between objects in the database by following links). 相似文献
37.
There is a sharp boundary between basic and applied research in the organizational structure of the US Department of Energy (DOE). In this work, we consider a branch of DOE that was designed to operate across this boundary: the Advanced Research Projects Agency – Energy (ARPA-E). We hypothesize that much of energy research cannot be neatly categorized as basic or applied and is more productive outside of the confines of the basic/applied dichotomy; ARPA-E gives us an opportunity to test that hypothesis. We construct a novel dataset of nearly 4000 extramural financial awards given by DOE in fiscal years 2010 through 2015, primarily to businesses and universities. We collect the early knowledge outputs of these awards from Web of Science and the United States Patent and Trademark Office. Compared to similar awards from other parts of DOE, ARPA-E awards are significantly more likely to jointly produce both a publication and a patent. ARPA-E has been highly productive in creating new technology, while also contributing new scientific knowledge. This observation points to the productive overlap of science and technology in energy research and, more generally, for mission-oriented research funding organizations. 相似文献
38.
J. R. Pradeep R. Roopa P. Geeta V. F. Julius T. Venkatesh 《Indian journal of clinical biochemistry : IJCB》1996,11(2):158-161
A reddish glow localized within the iris was observed in the photographs of some individuals in the dark using an electric-arc flash. On repeated exposure and reprints of the same individuals to photography under similar conditions, the red glow persisted. Studies were under taken to analyze thein vitro effect of cupric ions on the activity of serum tyrosinase. A significant increase in the activity of tyrosinase was observed in the affected individuals as compared to the controls when cupric ion was supplementedin vitro. Studies also confirmed the inhibitory effect of benzoic acid on serum tyrosinase activityin vitro. Our preliminary studies have shown a significant decrease (p<0.001) in tyrosinase activity in the serum of the photosensitive individuals compared to controls which is consistent with the observed red glow on the photographic prints and reprints. 相似文献
39.
In the study of innovation institutions, it is important to consider how different institutional models can affect a research organization in conducting or funding successful work. As an industry collaborative, Semiconductor Research Corporation (SRC) provides an example of a privately funded institution that leverages the inputs of several member companies, along with federal funding, to accomplish innovation in its mission area. SRC has several component programs, all attempting to find innovative solutions to semiconductor problems, but on different time scales, and in different technology areas. But how does SRC use its resources to ensure these goals? Through data gathered from semi-structured qualitative interviews and SRC documentation, this paper addresses that question. SRC has found a way to leverage industry money to motivate and develop a robust field of university research for over 30 years. SRC uses several mechanisms for maintaining an application focused, member-centered decision process, institutional flexibility, and strong ties between industry contributors and university researchers. SRC has continued to keep its members satisfied by training thousands of graduate students for employment in their member companies, by focusing on precompetitive research that addresses industry requirements, and doing so in a manner that operates leanly, with low overhead to its funders. Given these successes, we identify aspects of SRC operations, such as a focus on its member company needs, frequent interactions between funders and researchers, flexible funding mechanisms, and focus on workforce development, that may be diffusible to innovation institutions, including federal research efforts. 相似文献
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