A remotely operated drug delivery system with an electrolytic pump and a thermo-responsive valve     

Ying Yi  Amir Zaher  Omar Yassine  Jurgen Kosel  Ian G. Foulds 《Biomicrofluidics》2015,9(5)

Implantable drug delivery devices are becoming attractive due to their abilities of targeted and controlled dose release. Currently, two important issues are functional lifetime and non-controlled drug diffusion. In this work, we present a drug delivery device combining an electrolytic pump and a thermo-responsive valve, which are both remotely controlled by an electromagnetic field (40.5 mT and 450 kHz). Our proposed device exhibits a novel operation mechanism for long-term therapeutic treatments using a solid drug in reservoir approach. Our device also prevents undesired drug liquid diffusions. When the electromagnetic field is on, the electrolysis-induced bubble drives the drug liquid towards the Poly (N-Isopropylacrylamide) (PNIPAM) valve that consists of PNIPAM and iron micro-particles. The heat generated by the iron micro-particles causes the PNIPAM to shrink, resulting in an open valve. When the electromagnetic field is turned off, the PNIPAM starts to swell. In the meantime, the bubbles are catalytically recombined into water, reducing the pressure inside the pumping chamber, which leads to the refilling of the fresh liquid from outside the device. A catalytic reformer is included, allowing more liquid refilling during the limited valve''s closing time. The amount of body liquid that refills the drug reservoir can further dissolve the solid drug, forming a reproducible drug solution for the next dose. By repeatedly turning on and off the electromagnetic field, the drug dose can be cyclically released, and the exit port of the device is effectively controlled.  相似文献   

The skeleton in the closet: should historians of science care about the history of mathematics?     

Alexander A 《Isis; an international review devoted to the history of science and its cultural influences》2011,102(3):475-480

Up until the 1950s, the history of mathematics was an integral part of the history of science. To George Sarton and his contemporaries, mathematics was the rational skeleton that organized science and held it together, and its history was a fundamental component of the broader history of science. But when historians began focusing on the cultural roots of science rather than its rational structure, the study of mathematics was marginalized and ultimately excluded from the history of science. The alienation between the two fields is detrimental to both, and in recent years there has been a sustained effort to reestablish meaningful communication between the two. This time, however, mathematics is seen not as the static skeleton of science but, instead, as a dynamic and historically evolving field in its own right-just like science itself. The new approach allows for a culturally sensitive study of mathematics, as well as a new and fruitful relationship between the history of science and the history of mathematics. The essays in this Focus section offer a sampling of the new approaches, opening the way to a rapprochement between fields that have gone their separate ways but should by rights be closely interconnected.  相似文献   

Léon Foucault: His Life, Times and Achievements     

Amir D. Aczel 《Science & Education》2004,13(7):675-687

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New insights on the utilization of ultrasonicated mustard seed cake: chemical composition and antagonistic potential for root-knot nematode,Meloidogyne javanica     

Nadeem  Hera  Malan  Pieter  Khan  Amir  Asif  Mohd  Ahmad Siddiqui  Mansoor  Tuhafeni Angombe  Simon  Ahmad  Faheem 《Journal of Zhejiang University. Science. B》2021,22(7):563-574

This study focused, for the first time, on the effect of ultrasonic features on the extraction efficiency of secondary metabolites in mustard seed cake(MSC). The nematostatic potential of sonicated seed cake was examined against the second-stage juveniles(J2 s) of root-knot nematode, Meloidogyne javanica. The results show that a 35 ppm(parts per million) concentration of a sonicated extract(SE) sample of MSC caused 65% J2 s mortality at 18 h exposure period in vitro. It also significantly suppressed the root-knot index(RKI=0.94) in tomato roots. The lethal concentration values for SE were 51.76, 29.79, and 13.34 ppm,respectively, at 6, 12, and 18 h of the exposure period, and the lethal concentration values for the non-sonicated extract(NSE)sample were 116.95, 76.38, and 55.59 ppm, respectively, at similar exposure time. Sinapine and gluconapin were identified as the major compounds in ultrasonic-assisted MSC. Because of the high extraction efficiency of metabolites in the SE, all treatments of SE were shown to be antagonistic to J2 s. Thus, this study of ultrasonication activity-based profiling of MSC may help generate target-based compounds at a scale relevant to the control of disease caused by nematodes in economic crops.  相似文献   

Business Analytics Competition (BAC@MC): A learning experience     

Salwa Ammar  Min Jung Kim  Amir H. Masoumi  Alin Tomoiaga 《Decision Sciences Journal of Innovative Education》2023,21(2):52-67

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The effects of teaching self-determination skills on the externalizing behaviors of students with emotional behavioral disorders     

Zahra Mansurnejad  Amir Ghamarani  Ahmad Yarmmohamadiyan 《Emotional and Behavioural Difficulties》2019,24(2):196-203

The purpose of the present study was to examine the effects of teaching self- determination skills on the externalizing behaviors of students with emotional and behavioral disorders. The Research method was quasi experimental with pre and post- test and control group. To achieve our goals, thirty students who received high scores in the Child Behavior Checklist (CBCL) were selected and randomly assigned to either the experimental group (N = 15) or the control group (N = 15). Students in the experimental group participated in 16 sessions (1 session per week) receiving Self determination curriculum (Field and Hoffman’s model) intervention, and the control group did not receive any training. The Child Behavior Checklist (CBCL) by participants was completed before and after intervention. MANOVA was used for data analysis. The findings showed that the effects of teaching self- determination skills on decreasing the externalizing behaviors of students with emotional and behavioral disorders was significant. The emerged finding can have clinical applications in prevention and treatment of student’s behavioral disorders. Implications and future directions for research and practice are discussed.  相似文献   

Science Spots AR: a platform for science learning games with augmented reality     

Teemu H. Laine  Eeva Nygren  Amir Dirin  Hae-Jung Suk 《Educational technology research and development : ETR & D》2016,64(3):507-531

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Discomfort as a means of pre-service teachers’ professional development – an action research as part of the ‘Research Literacy’ course     

Aliza Amir  Daphna Mandler  Sara Hauptman  Dvora Gorev 《欧洲师范教育杂志》2017,40(2):231-245

This paper focus on defining a research question while conducting action research among third-year students attending a course on Research Literacy at a teacher education college. This paper discusses the process of preparing for and conducting action research among third-year students attending a course on Research Literacy at a teacher education college. The students were asked to conduct an action research on their classroom activities. The aim of this article is to present the process and pinpointing the discomfort of the students in formulating a research question suited to action research thanks to two prerequisite conditions: the ‘safe space’ and the ‘tender spot’. The research findings illustrate that the students had difficulty defining their ‘tender spot’. It was necessary to create a ‘safe space’. Furthermore, the findings show that the ‘tender spot’ issues were associated with disciplinary content far more than with generic lesson management or classroom management issues. The approach discussed here is leading to positive change and it may be that this professional development tool can facilitate the induction of novice teachers everywhere.  相似文献   

蝶翼恋语     

陈俪俪 《海外英语》2003,(9):24-26

Tanya got out of the bed while the sun was still asleep.She looked outthe window;even the stars were lost in the dark.Mike,her husbandwas still in bed and so were her four kids.Even their sleep couldn’telude her from doing them service.She had to orchestrate her work tothe microscopic details.From pressing clothes to polishing shoes,findingmatching socks to arranging school bags,fixing up breakfast to preparingsnack-boxes,she was unthankfully supposed to make it all happen like a magicwand.And to her own compulsory fault,she did it all;like a magic wand. Life ran like a wheel.The circle started every morning and ended up latein the night,and then morning appeared again.There was no pause,no rest,not even a slight curve to insert change.She condemned herself for not ex-periencing even a thought of ever getting out of this circle.She had committedherself to the orbit of life.  相似文献   

Ethnic Diversity and Inclusive School Environments     

Adrienne Nishina  Jakeem Amir Lewis  Amy Bellmore  Melissa R. Witkow 《教育心理学家》2019,54(4):306-321

Inclusive school contexts can promote psychological and social adjustment and enhance learning among students. Changing demographics and 21st-century workplace needs suggest that ethnic diversity is one important dimension of inclusion to consider. This article presents 4 suggestions for how schools can facilitate inclusivity for ethnic diversity that are recommended to be employed in conjunction with one another: (a) school and classroom ethnic composition (i.e., increased ethnic diversity), (b) positive ethnic identity for ethnic minority students, (c) multicultural/diversity training and cooperative learning, and (d) the promotion of social competence and prosocial behaviors. Developmental considerations are discussed and a case is made that improving individual students’ functioning can ultimately promote inclusivity for all students. Assisting students to be ready and able to form friendships with peers from ethnically diverse backgrounds provides them with valuable experience and skills that they can carry forward to new educational, community, and workplace settings.  相似文献