Labor migrants’ self-empowerment via participation in a diasporic magazine: Filipinos at Manila-Tel Aviv     

Amit Kama 《亚洲交流杂志》2013,23(3):223-238

This study delves into the motivations, symbolic rewards, and experiences of Filipinos involved in the creation of a magazine catering to the Filipino migrant workers’ community in Israel. Although practices of resistance are the prevailing framework within research about diasporic media, this paper offers another perspective of the construction of a subjugated minority's sphericule. Power (or lack thereof) is not necessarily a basic force of motivation. Participation in cultural production is not perceived as a journalistic endeavor by Filipinos, but a rare and crucial opportunity to be heard, to have a voice, to win over coerced living circumstances of alienation, solitude, and hard work. In this context they are not ‘just the caregiver,’ but accomplished writers, winners of competitions, and recipients of respect. Empowerment is derived from pleasure; it is grounded in recreational gratifications and a sense of mission that have no political dimensions.  相似文献   

Oxidative Stress and Its Relationship With Adenosine Deaminase Activity in Various Stages of Breast Cancer     

Mridula Mahajan  Nitika Tiwari  Ritu Sharma  Sukhraj Kaur  Neetirajan Singh 《Indian journal of clinical biochemistry : IJCB》2013,28(1):51-54

Reactive oxygen species (ROS) cause damage to the DNA producing mutations and formation of tumours such as carcinoma of breast. Tumour cells are known to produce ROS at a greater pace than the non-transformed cells. The increased production of reactive oxygen species causes oxidative stress leading to cell proliferation and hence increased inflammatory conditions. The present study was aimed to investigate the role of oxidative stress in the pathogenesis of breast cancer. Females suffering from breast cancer had significantly decreased Superoxide dismutase (SOD) and reduced glutathione (GSH) levels in comparison to normal females. The compromised antioxidant defence system produces the oxidative stress which in turn creates the inflammatory response shown by concomitant increased adenosine deaminase (ADA) activity in female patients. ADA diminishes the protective molecule adenosine. There were significant variations (p < 0.01) in ADA activity with different clinical stages (stage 1–4) of breast cancer suggesting thereby that estimation of ADA activity can be used as a diagnostic tool to detect the stage of cancer along with cytological studies. Mastectomy was performed and post-operatively serum SOD and ADA activity and plasma GSH levels were estimated. There was a statistically significant increase in activity of SOD and levels of GSH while serum ADA activity decreased significantly, suggesting thereby that oxidative stress is responsible for increased cell proliferation and hence the inflammatory conditions in CA breast that got ameliorated post-operatively.  相似文献   

Circadian Rhythm of Serum Cortisol in Female Patients with Fibromyalgia Syndrome     

Ghizal Fatima  Siddharth Kumar Das  Abbas Ali Mahdi  Nar Singh Verma  Faizan Haider Khan  Amit Mani Kumar Tiwari  Tabrez Jafer  Baby Anjum 《Indian journal of clinical biochemistry : IJCB》2013,28(2):181-184

Fibromyalgia syndrome (FMS) patients have disturbed sleep patterns which may lead to altered circadian rhythm in serum cortisol secretion. The aim of this study was to assess circadian changes, if any, in serum cortisol levels in female patients with FMS. Cortisol levels were estimated every 6 h during 24 h period; in 40 female patients satisfying ACR criteria for FMS (Age 36.4 ± 9.9), and 40 healthy females without FMS (Age 33.8 ± 11.1). A significant difference in the night time serum cortisol level was observed among the patients and control groups (patients, 12.9 ± 9.7 controls 5.8 ± 3.0; p < 0.01). However, no significant difference was found in serum cortisol levels in patients and control groups in the morning (patients, 28.4 ± 13.2 controls, 27.6 ± 14.5; p > 0.05), afternoon (patients, 14.4 ± 5.6 controls, 14.0 ± 6.6; p > 0.05) and evening hours (patients, 10.9 ± 5.8 controls, 8.9 ± 3.6; p > 0.05). It could be concluded that there is an abnormality in circadian secretion of cortisol in female FMS patients.  相似文献   

Microfluidic platform for the study of intercellular communication via soluble factor-cell and cell-cell paracrine signaling     

Matthew B. Byrne  Lisa Trump  Amit V. Desai  Lawrence B. Schook  H. Rex Gaskins  Paul J. A. Kenis 《Biomicrofluidics》2014,8(4)

Diffusion of autocrine and paracrine signaling molecules allows cells to communicate in the absence of physical contact. This chemical-based, long-range communication serves crucial roles in tissue function, activation of the immune system, and other physiological functions. Despite its importance, few in vitro methods to study cell-cell signaling through paracrine factors are available today. Here, we report the design and validation of a microfluidic platform that enables (i) soluble molecule-cell and/or (ii) cell-cell paracrine signaling. In the microfluidic platform, multiple cell populations can be introduced into parallel channels. The channels are separated by arrays of posts allowing diffusion of paracrine molecules between cell populations. A computational analysis was performed to aid design of the microfluidic platform. Specifically, it revealed that channel spacing affects both spatial and temporal distribution of signaling molecules, while the initial concentration of the signaling molecule mainly affects the concentration of the signaling molecules excreted by the cells. To validate the microfluidic platform, a model system composed of the signaling molecule lipopolysaccharide, mouse macrophages, and engineered human embryonic kidney cells was introduced into the platform. Upon diffusion from the first channel to the second channel, lipopolysaccharide activates the macrophages which begin to produce TNF-α. The TNF-α diffuses from the second channel to the third channel to stimulate the kidney cells, which express green fluorescent protein (GFP) in response. By increasing the initial lipopolysaccharide concentration an increase in fluorescent response was recorded, demonstrating the ability to quantify intercellular communication between 3D cellular constructs using the microfluidic platform reported here. Overall, these studies provide a detailed analysis on how concentration of the initial signaling molecules, spatiotemporal dynamics, and inter-channel spacing affect intercellular communication.  相似文献   

Maturity models in LIS study and practice     

Amit Tiwari  Devika P. Madalli 《Library & information science research》2021,43(1):101069

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Ultra-sensitive hybrid diamond nanothermometer     

Chu-Feng Liu  Weng-Hang Leong  Kangwei Xia  Xi Feng  Amit Finkler  Andrej Denisenko  Jrg Wrachtrup  Quan Li  Ren-Bao Liu 《国家科学评论(英文版)》2021,8(5)

Nitrogen-vacancy (NV) centers in diamond are promising quantum sensors because of their long spin coherence time under ambient conditions. However, their spin resonances are relatively insensitive to non-magnetic parameters such as temperature. A magnetic-nanoparticle-nanodiamond hybrid thermometer, where the temperature change is converted to the magnetic field variation near the Curie temperature, were demonstrated to have enhanced temperature sensitivity () (Wang N, Liu G-Q and Leong W-H et al. Phys Rev X 2018; 8: 011042), but the sensitivity was limited by the large spectral broadening of ensemble spins in nanodiamonds. To overcome this limitation, here we show an improved design of a hybrid nanothermometer using a single NV center in a diamond nanopillar coupled with a single magnetic nanoparticle of copper-nickel alloy, and demonstrate a temperature sensitivity of . This hybrid design enables detection of 2 mK temperature changes with temporal resolution of 5 ms. The ultra-sensitive nanothermometer offers a new tool to investigate thermal processes in nanoscale systems.  相似文献   

Atrazine biodegradation efficiency, metabolite detection, and trzD gene expression by enrichment bacterial cultures from agricultural soil     

Robinson David Jebakumar SOLOMON  Amit KUMAR  Velayudhan SATHEEJA SANTHI 《Journal of Zhejiang University. Science. B》2013,14(12):1162-1172

Atrazine is a selective herbicide used in agricultural fields to control the emergence of broadleaf and grassy weeds. The persistence of this herbicide is influenced by the metabolic action of habituated native microorganisms. This study provides information on the occurrence of atrazine mineralizing bacterial strains with faster metabolizing ability. The enrichment cultures were tested for the biodegradation of atrazine by high-performance liquid chromatography(HPLC) and mass spectrometry. Nine cultures JS01.Deg01 to JS09.Deg01 were identified as the degrader of atrazine in the enrichment culture. The three isolates JS04.Deg01, JS07.Deg01, and JS08.Deg01 were identified as efficient atrazine metabolizers. Isolates JS04.Deg01 and JS07.Deg01 produced hydroxyatrazine(HA) N-isopropylammelide and cyanuric acid by dealkylation reaction. The isolate JS08.Deg01 generated deethylatrazine(DEA), deisopropylatrazine(DIA), and cyanuric acid by N-dealkylation in the upper degradation pathway and later it incorporated cyanuric acid in their biomass by the lower degradation pathway. The optimum pH for degrading atrazine by JS08.Deg01 was 7.0 and 16S rDNA phylogenetic typing identified it as Enterobacter cloacae strain JS08.Deg01. The highest atrazine mineralization was observed in case of isolate JS08.Deg01, where an ample amount of trzD mRNA was quantified at 72 h of incubation with atrazine. Atrazine bioremediating isolate E. cloacae strain JS08.Deg01 could be the better environmental remediator of agricultural soils and the crop fields contaminated with atrazine could be the source of the efficient biodegrading microbial strains for the environmental cleanup process.  相似文献   

Discovery of parity violation     

Amit Roy 《Resonance》2005,10(12):164-175

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Characterization of a Double Heterozygote HbE/β+ Thalassemia IVS 1-1 [G>T] in a Juvenile Diabetic     

Vijay S. Bhat  S. Lokeshwarappa  Amit Kumar Mandal 《Indian journal of clinical biochemistry : IJCB》2015,30(2):238-242

The present case report describes the molecular and proteomic based study of Hb variant HbE associated with β⁺ thalassemia IVS 1-1 G>T, in a juvenile diabetic patient. Given the ethnic origin and mobility of the variant hemoglobin at alkaline pH, HbE would be suspected. But hematologically and clinically abnormality being detected, HPLC and Electrophoresis not being able to characterize due to retention time and band being in region of HbA2, respectively, further characterization of hemoglobinopathy was made using MALDI and IVS 1-1 G>T being validated by reverse dot blot hybridization. Capillary electrophoresis was also employed in order to separate HbE and HbA2 bands. This case report being first of its kind, wherein a HbE/β⁺ thalassemia has been characterized using multiple techniques.  相似文献   

Great experiments in physics     

Amit Roy 《Resonance》1998,3(9):6-13

Transistors have revolutionised the electronics and communications industries. An account of the discovery of the transistor effect is given along with the experiments leading to the discovery.  相似文献