Oxidative stress is the primary event: Effects of ethanol consumption in brain     

Subir Kumar Das  Hiran K. R.  Sukhes Mukherjee  D. M. Vasudevan 《Indian journal of clinical biochemistry : IJCB》2007,22(1):99-104

Damaging effects of reactive oxygen species on living systems are well documented. They include oxidative attack on vital cell constituents. Chronic ethanol administration is able to induce an oxidative stress in the central nervous system. In the present study, 16–18 week-old male albino rats of Wistar strain were exposed to different concentration of ethanol for 4 weeks. This exposure showed profound effect on body weight. Ascorbic acid level; and activities of alkaline phosphatase and aspartate transaminase in the brain are dependent on the concentration of ethanol exposure. Chronic ethanol ingestion elicits statistically significant increase in thiobarbituric acid reactive substances level and decrease in gluatathione level in the brain. It reduces superoxide dismutase, catalase, glutathione peroxidase, and glutathione reductase activities in a dose dependent manner. However, histological examination could not reveal any pathophysiological changes. Therefore, we conclude that biochemical alterations and oxidative stress related parameters respond early in alcoholism than the histopathological changes in brain.  相似文献   

Evolutionary stable strategy     

Jayanti Ray-Mukherjee  Shomen Mukherjee 《Resonance》2016,21(9):803-814

Every behaviourally responsive animal (including us) make decisions. These can be simple behavioural decisions such as where to feed, what to feed, how long to feed, decisions related to finding, choosing and competing for mates, or simply maintaining ones territory. All these are conflict situations between competing individuals, hence can be best understood using a game theory approach. Using some examples of classical games, we show how evolutionary game theory can help understand behavioural decisions of animals. Game theory (along with its cousin, optimality theory) continues to provide a strong conceptual and theoretical framework to ecologists for understanding the mechanisms by which species coexist.  相似文献   

Librarians’ perceptions of knowledge management in developing countries: A case with Indian academic libraries     

Mohammad Nazim  Bhaskar Mukherjee 《International Information and Library Review》2013,45(1-2):63-76

Abstract

The purpose of this paper is to examine librarians' perceptions of knowledge management, including its concept, potential applications, benefits and major challenges of its applications in Indian academic libraries. A structured questionnaire, containing both open and close-ended questions, was sent by postal mail to 30 librarians of academic libraries in India of which 15 questionnaires were returned. Respondents were asked to define knowledge management and answer questions on its potential applications, benefits and major challenges of implementation in academic libraries. Respondents were also allowed to specify their own views on the subject. The findings of the study show that the levels of understanding of KM concepts among librarians are varied and most of them view KM as the management of information resources, services and systems using technology or specific processes for the capture and use of explicit knowledge, rather sharing and using tacit knowledge. They have positive attitudes towards the applications of knowledge management into academic library practice, and not only because this can bring academic libraries closer to their parent organization, but also because it may help them to survive in an increasingly challenging environment. Although, librarians in the present study acknowledged that they are involved in the practices of knowledge management but these were perceived as basic information management activities. Lack of understanding of knowledge management concepts and its benefits, knowledge sharing culture, top management commitment, incentives and rewards, financial resources and information technology infrastructure are perceived as the major barriers for incorporating knowledge management into academic library practice.  相似文献   

Stretching Every Dollar: The Impact of Personal Financial Stress on the Enrollment Behaviors of Working and Nonworking Community College Students     

Moumita Mukherjee  Linda Serra Hagedorn  Agustina Purnamasari  Franco Santiago Martinez 《Community College Journal of Research & Practice》2013,37(9):551-565

ABSTRACT

Using 1,400 survey responses collected from two large urban community college systems in Texas, this study examined how students’ financial habits, stress, and well-being influenced their enrollment behaviors. Working students, compared to their nonworking peers, reported significantly lower levels of overall financial well-being. After controlling for other relevant predictors of persistence, regression results showed that students with lower financial well-being and higher financial stress were more likely to doubt their ability to complete college. Results for the restricted sample of working students revealed a strong relationship between a student’s financial well-being and stress. These students also reported having to reduce their semester course load and/or stopping out for a semester in order to work more hours to pay for expenses. These findings suggest that initiatives aimed at helping students improve their financial literacy and money management skills may be an effective, yet underutilized, way to improve retention rates at community colleges.  相似文献   

Teaching Science for Empowerment In an Urban Classroom: A Case Study of a Hmong Teacher     

Bhaskar Upadhyay 《Equity & Excellence in Education》2013,46(2):217-232

This is a case study of Lee, a Hmong teacher, who reflects on her own schooling experiences in order to develop a culturally sensitive pedagogy based on empowerment and funds of knowledge. The findings indicate that Lee teaches science effectively using culturally sensitive pedagogy—utilizing Hmong students' and parents' funds of knowledge in science teaching and learning. The findings further indicate that Lee negotiates challenges and tensions associated with her science instructions by partnering with parents and some teachers.  相似文献   

Society,Schools And Progress in India by Sir John Sargent. Long Island City,N.Y.: Pergamon Press, 1968. 238 pp. $5.50, $4.50 paper     

K. C. Mukherjee 《The Educational forum》2013,77(1):140-141

  相似文献   

Call for submission: review essays in cultural studies of science education     

Bhaskar Upadhyay 《Cultural Studies of Science Education》2009,4(2):485-486

  相似文献   

Effects of chronic ethanol exposure on renal function tests and oxidative stress in kidney     

Subir Kumar Das  Sowmya Varadhan  L. Dhanya  Sukhes Mukherjee  D. M. Vasudevan 《Indian journal of clinical biochemistry : IJCB》2008,23(4):341-344

After administration, ethanol and its metabolites go through the kidneys and are excreted into urine. The kidney seems to be the only vital organ generally spared in chronic alcoholics. Therefore, we investigated the multiple effects of chronic ethanol exposure on renal function tests and on oxidative stress related parameters in the kidney. Chronic ethanol (1.6 g ethanol/ kg body weight/ day) exposure did not show any significant change in relative weight (g/ 100g body weight) of kidneys, serum calcium level or glutathione s-transferase activity. However, urea and creatinine concentration in serum, and TBARS level in kidney elevated significantly, while reduced glutathione content and activities of glutathione peroxidase, glutathione reductase and superoxide dismutase diminished significantly after 12 weeks of ethanol exposure. Catalase activity showed increased activity after 4 weeks of ethanol exposure and decreased activity after 12 weeks of ethanol exposure. Genesis of renal ultrastructural abnormalities after 12 weeks of ethanol exposure may be important for the development of functional disturbances. This study revealed that chronic ethanol exposure for longer duration is associated with deleterious effects in the kidney.  相似文献   

Assessment of quality of higher education in hostile environment: an analysis on provincialised colleges under Assam University Silchar     

Prasun Das  Srabanti Mukherjee  Suprabir Dutta Roy 《Quality in Higher Education》2016,22(1):36-48

Historically low average pass rate has been a perennial challenge for the universities and provincialised colleges in the North-Eastern states of India (Assam, Meghalaya, Mizoram, Nagaland, Tripura, Manipur and Arunachal Pradesh). Pass rate refers to the proportion of students promoted from one semester to the next and also the proportion of students who pass the final examination to be a graduate. The paper attempts to trace the key parameters for quality improvement for higher education in the region and subsequently augment the pass rate. An inductive content analysis was conducted based on focus group interviews at various levels at Assam University, Silchar and its affiliated provincialised colleges. The four broad categories thus identified (academic, administrative, socio-economic and placement issues) were subjected to Pareto 80-20 principle to identify the issues that are to be given priority for evolving the system. The study would help the administrators to measure the quality of higher education system in a hostile environment characterised by adverse topography, political disturbances, skewed distribution of income, widespread poverty and lack of literacy.  相似文献   

Using first-order cognitive analysis to understand problem solving behavior: An example from accounting     

Jesse F. Dillard  R. Bhaskar  Ray G. Stephens 《Instructional Science》1982,11(1):71-92

We report a study of human problem solving in the accounting domain. This study has three characteristics. First, it is explicitly intended to aid in the development of instructional materials. Second, it uses a powerful task analyzing scheme as the basis for its conclusions. Third, we use a technique called First-Order Cognitive Analysis that combines the advantages of task analysis to overcome some of the traditional methodological problems posed to protocol analysis. Our representational scheme, KO, seems to be largely valid as a basis for reasoning about cognition, although only three subjects were studied.  相似文献