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71.
This article queries whether consonant sonority (sonorant vs. obstruent) and status (coda vs. onset) within intervocalic clusters influence syllable-based segmentation strategies. We used a modified version of the illusory conjunction paradigm to test whether French beginning, intermediate, and advanced readers were sensitive to an optimal “sonorant coda–obstruent onset” sonority profile within the syllable boundaries as a cue for a syllable-based segmentation. Data showed that children used a syllable-based segmentation that improved with reading skills and age. The results are discussed to support that the visual letter detection within pseudowords primarily and early relies on acoustic-phonetic cues within the syllable boundaries, whereas the syllable effect seems to be developmentally constrained by reading skills and age.  相似文献   
72.
In the last few years the improved performances of graphics hardware and the growing availability of broadband internet connections have eventually led to effectively adding a third dimension to web interfaces, achieving what is commonly referred to as Web3D. Nevertheless, these technologies are not yet widespread, especially in the cultural sector, for at least two factors: technological limitations, mostly in the lack of coherent and effective metaphors to visualize and interact with digital cultural assets using the third-dimension as an added value rather than as a stylish gadget, and communication issues, as, despite the principles stated in the London Charter aimed at ensuring technical and intellectual rigor for the digital visualization of cultural heritage, a proper way to deal with relevant and sustainable 3D information is not yet completely established. For this reason this paper focuses on identifying and analyzing the aspects that may contribute to a more efficient use of Web3D technologies to access cultural content, in order to set up a set of development standards aiming to encourage web-based learning and guaranteeing systems accessible and usable by the widest possible audience.  相似文献   
73.
Cell fusion consists of inducing the formation of a hybridoma cell containing the genetic properties of the progenitor cells. Such an operation is usually performed chemically or electrically. The latter method, named electrofusion, is considered as having a strong potential, due to its efficiency and non-toxicity, but deserves further investigations prior to being applicable for key applications like antibody production and cancer immunotherapy. Indeed, to envision such applications, a high amount of hybrid cells is needed. In this context, we present in this paper a device for massive cell pairing and electrofusion, using a microarray of non-connected conductive pads. The electrofusion chamber––or channel––exposes cells to an inhomogeneous electric field, caused by the pads array, enabling the trapping and pairing of cells with dielectrophoresis (DEP) forces prior to electrofusion. Compared to a mechanical trapping, such electric trapping is fully reversible (on/off handling). The DEP force is contactless and thus eases the release of the produced hybridoma. Moreover, the absence of wire connections on the pads permits the high density trapping and electrofusion of cells. In this paper, the electric field mapping, the effect of metallic pads thickness, and the transmembrane potential of cells are studied based on a numerical model to optimize the device. Electric calculations and experiments were conducted to evaluate the trapping force. The structure was finally validated for cell pairing and electrofusion of arrays of cells. We believe that our approach of fully electric trapping with a simple structure is a promising method for massive production of electrofused hybridoma.  相似文献   
74.
The aim of this study was to determine whether there is an effect of time of day on the adaptation to strength training at maximal effort. Fourteen participants took part in this experiment. Their peak anaerobic power (Wingate anaerobic test) and peak knee extension torque at six angular velocities (1.05, 2.10, 3.14, 4.19, 5.24 and 6.29 rad · s -1 ) were recorded in the morning (between 07:00 and 08:00 h) and in the evening (between 17:00 and 18:00 h) just before and 2 weeks after a 6 week course of regular training. Seven of them trained only in the morning and seven only in the evening. Multivariate analysis of variance revealed a significant group 2 pre-/post-training 2 time of day interaction effect for peak torque and peak anaerobic power. Before training, in both groups, peak torque and peak anaerobic power were significantly higher in the evening than in the morning. After training, there was no significant difference in peak torque and peak anaerobic power between the morning and the evening for the morning training group. In contrast, in the evening training group, peak torque and peak anaerobic power were higher in the evening than in the morning. As a result of training, both peak torque and peak anaerobic power increased from their initial values as expected. The morning training group improved their peak anaerobic power significantly in the morning and in the evening, the absolute increase being larger in the morning than in the evening. The evening training group did not improve their peak anaerobic power in the morning, whereas it improved significantly in the evening. Although peak torque was significantly improved by training in the morning and evening in both groups, the absolute increase was greater in the morning than in the evening in the morning training group, whereas the opposite was the case for the evening training group. These results suggest that training twice a week at a specific hour increases the peak torque and the peak anaerobic power specifically at this hour and demonstrates that there is a temporal specificity to strength training.  相似文献   
75.
Abstract

In this study, we examined fat oxidation rates during exercise in obese pubescent boys. Three groups of pubescent boys (16 pre-pubescent, Tanner's stage I; 16 pubescent, Tanner's stage III; and 14 post-pubescent, Tanner's stage V) performed a graded test on a leg cycle ergometer. The first step of the test was fixed at 30 W and power was gradually increased by 20 W every 3.5 min. Oxygen consumption ([Vdot]O2) and carbon dioxide production ([Vdot]CO2) were determined as the means of measurements during the last 30 s of each step, which allowed us to calculate fat oxidation rates versus exercise intensity. Between 20 and 50% of peak oxygen consumption ([Vdot]O2peak), fat oxidation rate in relative values (mg · min?1 · kg FFM?1) decreased continuously with pubertal development. In the same way, the maximum rate of fat oxidation occurred at a lower percentage of [Vdot]O2peak (pre-pubescent: 49.47 ± 1.62%; pubescent: 47.43 ± 1.26%; post-pubescent: 45.00 ± 0.97%). Our results confirm that puberty is responsible for a decrease in fat free mass capacities to use fat during exercise. The results suggest that post-pubescent obese boys need to practise physical activity at a lower intensity than pre-pubescent boys to enhance lipolysis and diminish adipose tissue and the consequences of obesity.  相似文献   
76.
Abstract

Thermoneutral water immersion increases cardiac preload and changes the neuroendocrine settings of blood volume regulation. The resulting marked diuresis may lead to significant haemodynamic changes after the end of a prolonged water immersion. Ten volunteers underwent 6 h of complete thermoneutral water immersion. Changes in cardiovascular status were assessed 1 h and 16 h after water immersion. Haemodynamic changes were assessed by Doppler echocardiography. Arterial wall distensibility was estimated by pulse wave velocity analysis. One hour after water immersion, mean weight loss was 1.78 kg and urine volume amounted to 1.5 litres. Echocardiographic measurements evidenced a significant decrease in dimensions of the left cardiac chambers and inferior vena cava. The decreased cardiac preload was paralleled by a lower stroke volume and cardiac output. A peripheral vasoconstriction associated with a relative decrease in the lower limb blood flow was evidenced by an increase in carotid-pedal pulse wave velocity and by a decrease in ankle brachial index. Sixteen hours after water immersion, cardiac preload and cardiac output remained below baseline values and peripheral vascular tone was still higher than at baseline. Marked haemodynamic changes had not returned to baseline 16 h after water immersion. There is a need to design fluid-replacement protocols to improve this recovery.  相似文献   
77.
78.
The main objective of this study is to identify the development of students’ self-reported use of metacognitive learning strategies during high school. Therefore, the study analyses the differential development patterns of 1,432 students, between grade 10 and 12, in a longitudinal sample. The results suggest that, from a global perspective, there is no development of students’ self-reported use of metacognitive learning strategies during high school. The expected gender-specific differences in favour of female students are replicated in this sample. However, the self-reported use of monitoring and evaluation strategies tends to converge between genders during high school, whereas the differences in the self-reported use of planning strategies remain stable. The consequences for the understanding of metacognitive development are discussed.  相似文献   
79.
Recent investigations have established the importance of higher-order thinking in the acquisition and application of learning skills in diverse domains of inquiry. Such findings have implications for enhancing the quality of thinking of all children but have particular significance for those minority students who historically have not performed as well as their more economically advantaged peers. Although much has been written about the construct, research is still needed to identify the specific processes underlying higher-order thinking and to examine its use among minority populations. A principal-factors extraction with varimax rotation analysis was used in the present study to clarify the nature and function of higher-order thinking among minority students from economically disadvantaged backgrounds. The results allowed for a specification of the mental processes associated with the construct and the extent to which students reported an awareness and use of these processes in academic problem-solving situations.  相似文献   
80.
The objective of this study is to clarify the functional roles of upper limb muscles during standing and seated cycling when power output increases. We investigated the activity of seven upper limb and trunk muscles using surface electromyography (EMG). Power outputs ranged from ~100–700 W with a pedalling frequency of 90 revolution per minute. Three-dimensional handle and pedal forces were simultaneously recorded. Using non-negative matrix factorisation, we extracted muscle synergies and we analysed the integrated EMG and EMG temporal patterns. Most of the muscles showed tonic activity that became more phasic as power output increased. Three muscle synergies were identified, associated with (i) torso stabilisation, (ii) compensation/generation of trunk accelerations and (iii) upper body weight support. Synergies were similar for seated and standing positions (Pearson’s r > 0.7), but synergy #2 (biceps brachii, deltoidus and brachioradialis) was shifted forward during the cycle (~7% of cycle). The activity levels of synergy #1 (latissimus dorsi and erector spinae) and synergy #2 increased markedly above ~500 W (i.e., ~+40–70% and +130–190%) and during periods corresponding to ipsi- and contralateral downstrokes, respectively. Our study results suggest that the upper limb and trunk muscles may play important roles in cycling when high power outputs are required.  相似文献   
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