排序方式： 共有17条查询结果，搜索用时 109 毫秒
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P. K. Nigam A. Jain P. Goyal R. Chitra 《Indian journal of clinical biochemistry : IJCB》2005,20(2):43-47
Heat stable fraction (HSF) of alkaline phosphatase (ALP) was evaluated as an adjunct to CA 125 as a tumour marker for epithelial
ovarian cancer in a follow-up study. In our study group 63.4% of patients had elevated HSF levels (≥10U/L) and 93.3% had elevated
CA 125 levels (>35U/mL). The sensitivity of CA 125 and HSF was 93.3% and 63.3% respectively. The decline in the activity of
HSF, over the pre-op levels was highly significant after the first (p=0.001) chemotherapy cycle and significant after the
second and third cycles (p<0.029). Thereafter, HSF activity was almost undetectable. The decrease in CA 125 levels over the
pre-op levels was significant after the first, second, third (p<0.001) and fourth (p<0.034) chemotherapy cycle. HSF can be
used alone or as an adjunct to CA 125 in screening and monitoring patients of ovarian carcinoma especially in remote areas
where sophisticated facilities are not available and in patients in which CA 125 levels are not raised preoperatively. 相似文献
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Huma Nasrat Surajeet K. Patra Binita Goswami Anju Jain Chitra Raghunandan 《Indian journal of clinical biochemistry : IJCB》2016,31(1):104-107
Polycystic ovary syndrome (PCOS) is a common endocrinological disorder among women of the reproductive age group with long term sequelae which include diabetes mellitus, hypertension and CAD. The present study was conducted to evaluate the association of leptin—an adipokine playing an important role in carbohydrate metabolism and markers of insulin resistance among women with PCOS. Sixty diagnosed cases of PCOS as per Rotterdam criteria were enrolled in this study after informed written consent. Insulin resistance was estimated using the homeostatic model assessment-insulin resistance (HOMA-IR). HOMA-IR was calculated as the product of the fasting plasma insulin value (mU/ml) and the fasting plasma glucose value (mg/dl), divided by 405 and HOMA β was calculated as 360 × [insulin]/([glucose] − 63) % (glucose in mg/dl). Estimation of serum leptin levels was done by ELISA using leptin ELISA kit from (DRG). A positive correlation of serum leptin levels was observed with markers of insulin resistance. Multiple regression analysis with HOMA-IR as dependent variable demonstrated a statistically significant contribution of fasting insulin levels. This study highlights the role of leptin in alterations in carbohydrate metabolism in patients with PCOS. 相似文献
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Chitra Upadhyaya Sandhya Mishra Peeyush Ajmera Praveen Sharma 《Indian journal of clinical biochemistry : IJCB》2004,19(2):48-52
Pregnancy is associated with increased demand of all the nutrients like Iron, Copper, Zinc etc. and deficiency of any of these
could affect pregnancy, delivery and out come of pregnancy. With this consideration, the study was conducted on 80 mothers
and newborns and 20 age matched control women. Out of 80 mothers, 34 had Iron deficiency anemia and their Hb levels were below
9.0 gm/d1. Pregnant women had significantly lower Iron and Zinc levels while Copper and Total Iron Binding Capacity (TIBC) were significantly
higher (P<0.001). Newborns had significantly elevated Iron and Zinc levels and low levels of Copper and TIBC as compared to
their mothers irrespective of Iron deficiency anemia. Micronutrient status of newborn was found to be dependent on their mother's
micronutrient status. Besides, results also suggest micronutrient interactions, which are reflected in Iron/Zinc, Iron/Copper
and Zinc/Copper ratios. In view of this, there is need for proper, adequate and balanced micronutrient supplementation during
pregnancy to affect a healthy outcome. 相似文献
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Ramalingam C 《Endeavour》2008,32(3):86-93
As an image-making tool for scientists studying the transient, instantaneous photography has long been seen as opening up a visual realm previously inaccessible to the inferior testimony of the human eye. But when photographic pioneer Henry Fox Talbot took the first photograph of a moving object by the light of an electric spark in 1851, he was guided by existing visual practices designed to create instantaneous vision in the eye itself. Exploring the background behind the peculiar subject of his experiment - a mechanically spinning disc - reveals a hidden prehistory of spark-illuminated photography: physicists' pre-photographic techniques for stopping time. 相似文献
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