G?del’s proof
3. Incompleteness theorems     

S M Srivastava 《Resonance》2007,12(5):71-84

After presenting the technique developed by G?del to examine questions about a theory such as Number Theory, Set Theory by the theory itself, we present the surprising Incompleteness Theorems of G?del.  相似文献   

Distress Tolerance Skills for College Students: A Pilot Investigation of a Brief DBT Group Skills Training Program     

Monicah Muhomba  Carla D. Chugani  Amanda A. Uliaszek  Divya Kannan 《Journal of College Student Psychotherapy》2017,31(3):247-256

This report outlines the evaluation of a brief dialectical behavior therapy (DBT) group skills training program for students presenting with serious psychological concerns (referral reasons included suicidality, self-injury, and substance use). Students were enrolled in distress tolerance groups ranging from 7–10 weeks. The majority of the students in the sample were receiving psychiatric medication, individual therapy, or both. All students (N = 22) demonstrated significantly improved scores on measures of emotion regulation and functional and dysfunctional coping. These results are the first to show that targeted skills training with DBT mindfulness and distress tolerance skills can produce beneficial outcomes in college students in the context of a short-term intervention.  相似文献   

An IAD type framework for Blockchain enabled smart tourism ecosystem     

Janardan Krishna Yadav  Deepika Chandra Verma  Srinivas Jangirala  Shashi Kant Srivastava 《The Journal of High Technology Management Research》2021,32(1):100404

The concept of smart tourism remains fuzzy when it comes to practice because of the lack of clarity on the roles and responsibilities of stakeholders in addition to complex institutional ecosystem that exist within the tourism industry. Further, trust and safety of the data generated due to the advancement of smart tourism in varied institutional arrangements pose huge challenges. Extant literature proposes that the application of decentralized ledger promises possible solutions to most of these problems due to the inherent features of the Blockchain technology. This suggestion raises two practical questions. First, does the sophisticated additional layer adds complexity to its practical application? Second, will the suggested solutions really lead to a win-win for all the stakeholders involved? In this study, we use Ostrom's action arena to examine the exchanges (information, contractual and monetary) between various stakeholders in a BCT enabled smart tourism of a Blockchain enabled tourism industry to answer these two questions.  相似文献   

Understanding social learning relations of international students in a large classroom using social network analysis     

Bart Rienties  YingFei Héliot  Divya Jindal-Snape 《Higher Education》2013,66(4):489-504

A common assumption in higher education is that international students find it difficult to develop learning and friendship relations with host students. When students are placed in a student-centred environment, international students from different cultural backgrounds are “forced” to work together with other students, which allows students to learn from different perspectives. However, large lecture rooms may provide fewer opportunities for students to work together in small groups. The purpose of this article is to understand how 191 international students from 34 cultural backgrounds and 16 host students build learning and friendship relations in a large classroom of 207 students. We have used an innovative mixed-method design of social network analysis in a pre- and post-test manner combined with two sets of focus groups. Using multiple regression quadratic assignment procedures, the results indicate that learning ties after 11 weeks were significantly predicted by the friendship and learning ties established at the beginning of the module, (sub)specialisation, and whether students were Chinese or not. Contrary to previous findings, team divisions played only a marginal role in building (new) learning relations. A substantial segregation between Confucian Asian, European international and UK students was present. Follow-up qualitative data highlighted that international students made a conscious effort to build friendship and learning relations primarily outside the formal team, which for some were along co-national lines, while others were pro-actively looking for new perspectives from multi-national students. These results indicate that the instructional design might have a strong influence on how international and host students work and learn together. We believe that this study is the first to provide an in-depth and unique understanding of how international students from different cultural backgrounds build friendship and learning-relationships with other students in- and outside their classroom over time in a large classroom of 200+ students.  相似文献   

Impact of CCL2 and Its Receptor CCR2 Gene Polymorphism in North Indian Population: A Comparative Study in Different Ethnic Groups Worldwide     

Vibha Singh  Neena Srivastava  Priyanka Srivastava  Rama Devi Mittal 《Indian journal of clinical biochemistry : IJCB》2013,28(3):259-264

Chemokine are small, inducible pro-inflammatory cytokines involved in many biological processes, such as migration of leukocytes, atherosclerosis, angiogenesis, tumor growth, and metastasis. Chemokine are also known to influence tumor cell’s activity. Specifically, tumor cells express chemokine receptors in a non random manner suggesting a role of chemokine in metastatic destination of tumor cells. The present study was conducted to determine distribution of (Chemokine receptor 2) CCR2 V64I, Chemokine ligand 2 CCL2 I/D, and CCL2 2518 A>G gene polymorphisms in North Indian population and compare with different populations globally. Polymerase chain reaction (PCR)-based analysis was conducted in 200 normal healthy individuals of similar ethnicity. Allelic frequencies in wild type (GG) of CCR2 V64I G>A were 63 % G; CCL2 I/D 42 % II; CCL2 2518 A>G 40.5 % A. The minor variant allele frequency in our population was as follows: 19.5 % for CCR2 V64I, 35.5 % for CCL2 I/D, 35.3 % for CCL2 2518 A>G. We further compared frequency distribution for these genes with various published studies in different ethnicity. Our results suggested that frequency in chemokine genes exhibit distinctive pattern in India that could be attributed to ethnicity variation. This could assist in high-risk screening of human exposed to environmental carcinogens and cancer predisposition in different ethnic groups. Thus, they signify an impact of ethnicity and provide a basis for future epidemiological and clinical studies.  相似文献   

“Proteoglycans—A promising front in cardiovascular research”     

D. K. Srivastava  P. P. Singh 《Indian journal of clinical biochemistry : IJCB》1992,7(1):1-2

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Lipoprotein (a): a Unique Independent Risk Factor for Coronary Artery Disease     

Anjali Manocha  L. M. Srivastava 《Indian journal of clinical biochemistry : IJCB》2016,31(1):13-20

The current epidemic affecting Indians is coronary artery disease (CAD), and is currently one of the most common causes of mortality and morbidity in developed and developing countries. The higher rate of CAD in Indians, as compared to people of other ethnic origin, may indicate a possible genetic susceptibility. Hence, Lp(a), an independent genetic risk marker for atherosclerosis and cardiovascular disease assumes great importance. Lp(a), an atherogenic lipoprotein, contains a cholesterol rich LDL particle, one molecule of apolipoprotein B-100 and a unique protein, apolipoprotein (a) which distinguishes it from LDL. Apo(a) is highly polymorphic and an inverse relationship between Lp(a) concentration and apo(a) isoform size has been observed. This is genetically controlled suggesting a functional diversity among the apo(a) isoforms. The LPA gene codes for apo(a) whose genetic heterogeneity is due to variations in its number of kringles. The exact pathogenic mechanism of Lp(a) is still not completely elucidated, but the structural homology of Lp(a) with LDL and plasmin is possibly responsible for its acting as a link between atherosclerosis and thrombosis. Upper limits of normal Lp(a) levels have not been defined for the Indian population. A cut off limit of 20 mg/dL has been suggested while for the Caucasian population it is 30 mg/dL. Though a variety of assays are available for its measurement, standardization of the analytical method is highly complicated as a majority of the methods are affected by the heterogeneity in apo(a) size. No therapeutic drug selectively targets Lp(a) but recently, new modifiers of apo(a) synthesis are being considered.  相似文献   

Prevalence of insulin resistance in first degree relatives of type-2 diabetes mellitus patients: A prospective study in north Indian population     

Arvind Kumar  Poornima Tewari  Sibasis S. Sahoo  Arvind Kumar Srivastava 《Indian journal of clinical biochemistry : IJCB》2005,20(2):10-17

A total of 172 first degree relatives (FDRs) and 178 controls were included in this study. All the cases and controls were subjected to various anthropometric measurements, fasting and postprandial glucose estimation, fasting insulin measurement and fasting lipid profile. Results revealed the prevalence of Impaired Fasting Glucose (IFG) (cases 37% Vs controls 11.6%), Impaired Glucose Tolerance (IGT) (cases 34.3% Vs controls 11.2%) and diabetes (cases 11.05% controls 3.37%) was significantly higher in first degree relatives. Insulin resistance was measured using various methods, which included fasting plasma insulin (FPI), Homeostasis Model Assessment for Insulin Resistance (HOMA_IR), insulin sensitivity index (ISI) (Mffm/l). Prevalence of insulin resistance (Insulin Resistance) as observed comparing FPI and HOMA_IR in cases and controls was 43.6% and 11.24% (P=0.005) and 37.8% and 12.47% (P=0.000) respectively. Prevalence of IR (Insulin Resistance) observed in cases having Normal Glucose Tolerance (NGT), Impaired Fasting Glucose (IFG), Impaired Glucose Tolerance (IGT) and diabetes mellitus measuring FPI Vs HOMA_IR was 37.5% vs 30.2%, 45% vs 40%, 38.98% vs 37.28% and 36.84% vs 31.57% as accordingly. However, ISI (Mffm/l) was not found to be a promising index for IR due to its poor specificity. Though HOMA is taken as gold standard for measurement of IR globally, our study observed fasting plasma insulin representing high sensitivity (89.7%) and specificity (93.3%) as compared to HOMA. Thus FPI had emerged in this work as a simple and reliable test for diagnosing insulin resistance across the population susceptible to develop diabetes including FDRs.  相似文献   

Serum Malondialdehyde (MDA) in relation to lipidemic status and atherogenic index     

J. Bhattacharjee  D. K. Srivastava 《Indian journal of clinical biochemistry : IJCB》1993,8(1):12-15

Lipid peroxidation (MDA) was studied spectrophotometrically in relation to lipidemic status and atherogenic index in IHD and IHD risk subjects. It was found to be significantly elevated compared to control subjects (P<0.005) in both the groups, showing a linear correlation with cholesterolemic status. The values were found to run parallel to atherogenic index. In 10% cases with borderline atherogenic index the lipid peroxidation was found to be highly elevated. It is speculated that it may have a future role as a marker for IHD risk specially in premature group.  相似文献   

Oxygen derived free radicals in clinical context     

V. K. Gupta  V. Mallika  Yashika Gupta  D. K. Srivastava 《Indian journal of clinical biochemistry : IJCB》1992,7(1):3-10

Oxygen derived free radicals have been implicated in a number of clinical disorders including atherosclerosis (1), ischemic heart disease (IHD) (2), post ischemic reperfusion injury (3) and respiratory distress syndrome (4). These radical are generated by sequential reduction of molecular oxygen; the primary product being superoxide anion (O₂ ^.−) which is subsequently reduced to hydrogen peroxide (H₂O₂), hydroxy1 radical (OH^.) and singlet oxygen (¹O₂). However the evidence for ODFR induced cell damage in various clinical disorders is still debated and rests largely on free radical scavenging studies, through electron paramagnetic resonance spectroscopic (EPRS) studies have provided direct evidence for ODFR generation following coronary artery ligation (5). By definition, a free radical is an atom, ion or molecule with one or more unpaired electrons (the presence of unpaired electron in a free radical being represented by a superscribed bold dot-R^.) and may be formed as a result of homolytic fission of a covalent bond or by electron transfer reactions, and may have cationic (NH₃ ⁺), anionic (O₂ ^.−) or neutral (NO) characteristics. The most important in vivo source for these radical species have been found to be univalent biochemical redox reactions involving oxygen. (a) A:B→A^.+B^. (b) A:+B→A^.+B^.  相似文献