Benzodiazepine administration prevents the use of error-correction mechanisms during fear extinction     

Genevra Hart  Nathan M. Holmes  Justin A. Harris  R. Frederick Westbrook 《Learning & behavior》2014,42(4):383-397

Three experiments examined the effect of systemic administration of the benzodiazepine midazolam on extinction and re-extinction of conditioned fear. Experiment 1 demonstrated that midazolam administration prior to extinction of a conditioned stimulus (CS) impaired that extinction when rats were subsequently tested drug free; however, extinction was spared if rats were extinguished, reconditioned, and re-extinguished under midazolam. Experiment 2 provided a replication of this effect within-subjects; rats were conditioned to two CSs (A and B), extinguished to one (A-), reconditioned to both, and then extinguished/re-extinguished to both stimuli in compound (AB-), under either vehicle or midazolam. On the drug-free test, rats given midazolam froze more to the CS that had been extinguished (B) than the one that been re-extinguished (A). The final experiment examined whether extinction under midazolam was regulated by prediction error. Rats were trained with three CSs (A, B, C) and extinguished to two (A-, C-). These stimuli then underwent additional extinction under midazolam or vehicle, with one CS now presented in compound with the non-extinguished CS (AB-, C-). Rats were then tested for fear of A relative to C. Rats given vehicle showed a deepening of extinction to A relative to C, as is predicted from error-correction models; however, rats given midazolam failed to show any such discrepancy in responding. The results are interpreted to indicate that the drug reduced prediction error during extinction by reducing fear, and rats were able to re-extinguish fear via a retrieval mechanism that is independent of prediction error.  相似文献   

Joseph Lauwerys     

Brian Holmes 《Compare》1982,12(1):59-65

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Obituary     

Professor Brian Holmes 《Compare》1994,24(1):97-102

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Comment on Barrow     

Mark Holmes 《Interchange》1993,24(3):233-236

The author continues his dialogue with Robin Barrow on the place of religion in public education (see pages 205 to 223 of this issue).  相似文献   

Alive!     

Holmes B 《New scientist (1971)》2005,185(2486):28-33

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Models in Comparative Education     

Brian Holmes 《Compare》1981,11(2):155-161

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Vocabulary and syntactic structures in adapted "classics" readers for deaf children     

T L Layton  K J Schmucker  D W Holmes 《American annals of the deaf》1979,124(4):433-443

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Response to intervention as a vehicle for distinguishing between children with and without reading disabilities: Evidence for the role of kindergarten and first-grade interventions     

Vellutino FR  Scanlon DM  Small S  Fanuele DP 《Journal of learning disabilities》2006,39(2):157-169

Children at risk for early reading difficulties were identified on entry into kindergarten, and half of these children received small-group intervention two to three times a week during their kindergarten year. The other half received whatever remedial assistance was offered by their home schools. These children were again assessed at the beginning of first grade, and those who continued to have difficulties in reading received either one-to-one daily tutoring offered by project teachers from the beginning to the end of first grade or whatever remedial assistance was offered by their home schools over the same time period. All target children were periodically assessed through the end of third grade. Results suggest that either kindergarten intervention alone or kindergarten intervention combined with first-grade intervention are both useful vehicles for preventing early and long-term reading difficulties in most at-risk children.  相似文献   

Human cancer genetics     

Li M  Albertson D 《Journal of Zhejiang University. Science. B》2006,7(2):164-164

Cancer is a genetic disorder.Although heredi-tary cancers account for only a small fraction of all tumors,most cancers are caused by a variable mix of heredity and environment that leads to accumulations of genetic alterations and then uncontrolled cell pro-liferations(Kops et al.,2005).In addition,genetic alteration is one of the a few most important bio-logical factors that determine the diagnosis and prognosis of different cancers and dictate the treat-ment strategies for cancer patients.Fu…  相似文献   

Thinking through practice: exploring ways of knowing,understanding and representing the complexity of teaching     

Donna Mathewson Mitchell 《Asia-Pacific Journal of Teacher Education》2013,41(4):414-425

In recent times there has been a cross-disciplinary amplification of interest in the concept of practice. In this context, there is a growing body of research considering how teaching and teacher education might be viewed using the conceptual lens of practice. In this article, I explore practice theories to identify common themes and principles that constitute a conceptual framework for the investigation of the lived experience of teaching. From this foundation, a methodological framework based on collaborative inquiry and postmodern emergence is derived. Examples are offered of the way the conceptual framework and methodological approach have been activated through the first stage of a research programme that collaboratively engages the dual voices of academic researcher and classroom practitioners as co-researchers. Analysis of qualitative data reveals the potential and limitations of this practice-based foundation as a way to know, understand and represent the complexity of teaching. In conclusion, the article develops a number of propositions as the basis for further research.  相似文献