我国网络经济发展的现状及影响   总被引：2，自引：0，他引：2  

刘健辉  陈安阳 《情报杂志》2005,24(3):120-122

讨论了网络经济的内涵 ,分析了我国网络经济发展的现状 ,探讨了网络经济对中国经济所产生的正、反两方面的重大影响。  相似文献   

适度超前推动科研基础平台建设 支撑我国高水平科技自立自强          下载免费PDF全文

汪洋  周园春  王彦棡  黎建辉  齐法制  何洪林  廖方宇 《中国科学院院刊》2022,37(5):652-660

科研基础平台是国家科技创新的基础性、战略性平台。近10年来，我国科研基础平台在科学观测水平、制造工艺水平、数据获取水平、开放共享水平、科学管理水平、开发利用水平方面取得了跨越式发展，高水平支撑我国科技创新活动。展望未来，新的科研范式变革正在悄然到来，新兴科研信息化基础平台不仅支撑重大科技基础设施和野外台站朝着更大规模、更精确、更先进的方向发展，其本身还将对科研范式变革起到重要的推动作用，成为重大科技突破的“加速器”与“倍增器”，成为我国跻身创新型国家前列和迈进世界科技强国的关键支撑。  相似文献   

Engineering G-quadruplex aptamer to modulate its binding specificity     

Long Li  Shujuan Xu  Xueyu Peng  Yuzhuo Ji  He Yan  Cheng Cui  Xiaowei Li  Xiaoshu Pan  Lu Yang  Liping Qiu  Jianhui Jiang  Weihong Tan 《国家科学评论(英文版)》2021,8(4)

The use of aptamers in bioanalytical and biomedical applications exploits their ability to recognize cell surface protein receptors. Targeted therapeutics and theranostics come to mind in this regard. However, protein receptors occur on both cancer and normal cells; as such, aptamers are now taxed with identifying high vs. low levels of protein expression. Inspired by the flexible template mechanism and elegant control of natural nucleic acid-based structures, we report an allosteric regulation strategy for constructing a structure-switching aptamer for enhanced target cell recognition by engineering aptamers with DNA intercalated motifs (i-motifs) responsive to the microenvironment, such as pH. Structure-switching sensitivity can be readily tuned by manipulating i-motif sequences. However, structure-switching sensitivity is difficult to estimate, making it equally difficult to effectively screen modified aptamers with the desired sensitivity. To address this problem, we selected a fluorescent probe capable of detecting G-quadruplex in complicated biological media.  相似文献   

PhysicalLiteracy的本土释义:体育素养or身体素养———兼论PhysicalLiteracy测评的能与不能          下载免费PDF全文

彭响  刘如  戴俭慧 《河北体育学院学报》2021,35(6):53-61

Physical Literacy作为一个西方舶来品,在本土释义过程中出现了 “体育素养”与 “身体素养”2种不同理解。在阐释 Physical Literacy提出背景、内涵与理论基础之后,对比分析两种不同理解的论证思路,指出 “体育素养”的释义是对具身性认知理论的忽视与窄化,也弱化了 PhysicalLit- eracy的丰富内涵与意义。“身体素养”是更科学、合理的解读与阐释,符合当前中国体育发展现实情形。进一步分析国内外 Physical Literacy的不同测评体系,指出当前的测评体系均未能较好诠释 Physical Literacy概念中的具身性认知理论,并对 Physical Literacy测评能与不能的问题进行探讨, 最后提出我国身体素养测评的展望。  相似文献   

Double lock of a potent human therapeutic monoclonal antibody against SARS-CoV-2     

Ling Zhu  Yong-Qiang Deng  Rong-Rong Zhang  Zhen Cui  Chun-Yun Sun  Chang-Fa Fan  Xiaorui Xing  Weijin Huang  Qi Chen  Na-Na Zhang  Qing Ye  Tian-Shu Cao  Nan Wang  Lei Wang  Lei Cao  Huiyu Wang  Desheng Kong  Juan Ma  Chunxia Luo  Yanjing Zhang  Jianhui Nie  Yao Sun  Zhe Lv  Neil Shaw  Qianqian Li  Xiao-Feng Li  Junjie Hu  Liangzhi Xie  Zihe Rao  Youchun Wang  Xiangxi Wang  Cheng-Feng Qin 《国家科学评论(英文版)》2021,8(3)

Receptor recognition and subsequent membrane fusion are essential for the establishment of successful infection by SARS-CoV-2. Halting these steps can cure COVID-19. Here we have identified and characterized a potent human monoclonal antibody, HB27, that blocks SARS-CoV-2 attachment to its cellular receptor at sub-nM concentrations. Remarkably, HB27 can also prevent SARS-CoV-2 membrane fusion. Consequently, a single dose of HB27 conferred effective protection against SARS-CoV-2 in two established mouse models. Rhesus macaques showed no obvious adverse events when administrated with 10 times the effective dose of HB27. Cryo-EM studies on complex of SARS-CoV-2 trimeric S with HB27 Fab reveal that three Fab fragments work synergistically to occlude SARS-CoV-2 from binding to the ACE2 receptor. Binding of the antibody also restrains any further conformational changes of the receptor binding domain, possibly interfering with progression from the prefusion to the postfusion stage. These results suggest that HB27 is a promising candidate for immuno-therapies against COVID-19.  相似文献