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Recently our group has reported experiments using an obstacle array to precondition the conformations of DNA molecules to facilitate their stretch in a microcontraction. Based upon previous successes simulating electrophoretic stretching in microcontractions without obstacles, we use our simulation model to study the deformation of DNA chains in a microcontraction preceded by an array of cylindrical obstacles. We compare our data to the experimental results and find good qualitative, and even quantitative, agreement concerning the behavior of the chains in the array; however, the simulations overpredict the mean stretch of the chains as they leave the contraction. We examine the amount of stretch gained between leaving the array and reaching the end of the contraction and speculate that the differences seen are caused by nonlinear electrokinetic effects that become important in the contraction due to a combination of field gradients and high field strengths. 相似文献
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美国湿地保护制度变迁研究 总被引:1,自引:0,他引:1
陈溪 Magdeline Laba Robertson Morgan Barbara Cosens 王子彦 陈雪 James Anderson Marinus Otte Christopher Craft David Feldman 李杨帆 刘晶岚 Patrick Sullivan 吕宪国 《资源科学》2016,38(4):777-789
本文提出了分析湿地保护制度变迁的理论框架,使不同国家的湿地保护制度研究能在统一语境下比较。首先基于科学计量学和系统研究方法筛选出公众、科学、政府和法律为影响湿地保护制度变迁的四个关键要素,并依赖博弈论工具建立了分析美国湿地保护制度的理论架构。基于这一架构,本文对包括关键利益相关者、政策执行路径、政策工具和管理挑战等内容的美国湿地政策史进行了讨论。对美国湿地保护制度的演化进行了四阶断之划分:“西进运动”与全民开垦(1900年之前)、“水鸟保护”与公众参与(1900-1970年)、核心法律与科学研究(1971-1980年)和完善制度与新的挑战(1980年至今)。分析得出如下结论:在湿地保护制度中,公众是源头、科学是前提、有效的政府管治和将湿地保护的规则和与政策制度化是关键。通过借鉴美国湿地保护制度变迁研究,本文构建了湿地保护制度变迁的“竹节模式”经验性模型,揭示了各动因之间的作用机理。虽然美国湿地保护制度也面临着公众教育、科学定义和政府管辖权等挑战,但中国的湿地管理者与政策制定者仍可从美国湿地政策执行的历史背景中吸取经验。同时本文的理论分析结构也可为自然资源及管理策略的研究提供参考。 相似文献
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The prominence afforded to literacy in the Irish Primary School Curriculum has received considerable attention in recent years, spurred by Programme for International Student Assessment (PISA) rankings, governmental priorities, public commentary and academic debate. At times, this discourse has presented literacy as a separate and distinct entity to the other areas of the curriculum, including the arts, social and scientific education. The current paper proposes a more integrated view of literacy’s role in the curriculum. Recent research on the teaching of literacy in the content areas has emphasised the potential of a disciplinary approach, which embraces the key skills, dispositions and forms of knowledge connected with reading, writing, speaking and listening in different disciplines. This paper examines some of the key features of disciplinary literacy, including its underpinning rationale and learning implications. It also highlights the potential for a disciplinary literacy lens in the review of the Primary School Curriculum, as well as associated opportunities and challenges. 相似文献
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Allison Gruner Gandhi Rachel Slama So Jung Park Patrick Russo Kendra Winner Robin Bzura 《Journal of research on educational effectiveness》2018,11(2):240-266
We used a comparative interrupted time series design to examine the impact of the Massachusetts' Wraparound Zone Initiative on student achievement, attendance, retention, and suspension. This initiative was designed to create coordinated district systems that allow schools to proactively and systematically address students' nonacademic needs. The state education agency awarded grants to seven high-need districts, each of which used the funds to support a select group of schools in implementing strategies that focused on school climate and culture, family engagement, systems to identify and address student needs, and community partnerships. Results from this study showed that students in Wraparound Zone schools performed better on state academic assessments than students in comparison schools, when considering prior achievement trends. Effects were statistically significant in the 3rd year of implementation. The impact on academic achievement was greatest for third- and fourth-grade students, and was particularly strong for English learners. There was no statistically significant overall impact on attendance, retention, or suspension. 相似文献