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11.
Priyanka Jamwal 《Resonance》2017,22(3):279-290
Jakkur Lake in the city of Bengaluru covers an approximate area of 55 hectares and primarily receives inflows from the Jakkur sewage treatment plant (STP) and an open storm drain. Jakkur STP discharges an average of 10 million litres of treated water daily (MLD) into the lake. The open drain discharges about 0.5 MLD of raw sewage into the lake. In the absence of environmental flows it becomes critical to assess the impact of nutrient flux on the quality of water, and design cost effective treatment solutions to address the issues of lake water quality. As part of this study, we have assessed the impact of these two primary inflows on the overall water quality of Jakkur Lake. The results have shown that nutrient inflows have led to the increase of chlorophyll-a levels, eventually causing hypereutrophication of Jakkur lake. We have also used simple mass balance approach to assess the contributions of in-lake activities (sedimentation and reaction) on removal of nutrients from the lake. We have concluded that the phosphorus load has to be reduced by approximately 96% from the current levels to prevent algal blooms within Jakkur Lake. 相似文献
12.
Vibha Singh Neena Srivastava Priyanka Srivastava Rama Devi Mittal 《Indian journal of clinical biochemistry : IJCB》2013,28(3):259-264
Chemokine are small, inducible pro-inflammatory cytokines involved in many biological processes, such as migration of leukocytes, atherosclerosis, angiogenesis, tumor growth, and metastasis. Chemokine are also known to influence tumor cell’s activity. Specifically, tumor cells express chemokine receptors in a non random manner suggesting a role of chemokine in metastatic destination of tumor cells. The present study was conducted to determine distribution of (Chemokine receptor 2) CCR2 V64I, Chemokine ligand 2 CCL2 I/D, and CCL2 2518 A>G gene polymorphisms in North Indian population and compare with different populations globally. Polymerase chain reaction (PCR)-based analysis was conducted in 200 normal healthy individuals of similar ethnicity. Allelic frequencies in wild type (GG) of CCR2 V64I G>A were 63 % G; CCL2 I/D 42 % II; CCL2 2518 A>G 40.5 % A. The minor variant allele frequency in our population was as follows: 19.5 % for CCR2 V64I, 35.5 % for CCL2 I/D, 35.3 % for CCL2 2518 A>G. We further compared frequency distribution for these genes with various published studies in different ethnicity. Our results suggested that frequency in chemokine genes exhibit distinctive pattern in India that could be attributed to ethnicity variation. This could assist in high-risk screening of human exposed to environmental carcinogens and cancer predisposition in different ethnic groups. Thus, they signify an impact of ethnicity and provide a basis for future epidemiological and clinical studies. 相似文献
13.
Ramesh Chandra Sujata K. Dass Priyanka Tomar Manisha Tiwari 《Indian journal of clinical biochemistry : IJCB》2001,16(2):145-152
As a stress agent, inducing apoptosis and blocking it, Cd can have both helpful and harmful effects. The atmosphere is a thin
envelope which makes the worid a global village. Cd is the most toxic metal in air. As both the first and second messenger
of the stress response, it is synergistically toxic with all other stressors, including many other carcinogens. Elimination
of Pb and its replacement with added benzene in gasoline appears to have increased the toxicity of atmospheric Cd. With scientific
understanding of the molecular basis of Cd's role in carcinogenesis and anti-carcinogenesis, primary cancer prevention can
be practiced by reducing Cd and chemical air pollution and educating the public on smoke cessation, healthy eating habits
and stress reduction. Using the existing information on Cd and its effects, determinations could be made on established cancers
so that individualized treatment protocols can be developed to improve patient care. 相似文献
14.
Harshini Sriram Twinkle Khanka Shweta Kedia Priyanka Tyagi Sitaram Ghogale Nilesh Deshpande Gaurav Chatterjee Sweta Rajpal Nikhil V Patkar Papagudi G Subramanian Sumeet Gujral Syed Hasan Prashant R Tembhare 《Biochemia medica : ?asopis Hrvatskoga dru?tva medicinskih biokemi?ara / HDMB》2021,31(3)
IntroductionMicroRNAs are small, non-coding RNA molecules that are becoming popular biomarkers in several diseases. However, their low abundance in serum/plasma poses a challenge in exploiting their potential in clinics. Several commercial kits are available for rapid isolation of microRNA from plasma. However, reports guiding the selection of appropriate kits to study downstream assays are scarce. Hence, we compared four commercial kits to evaluate microRNA-extraction from plasma and provided a modified protocol that further improved the superior kit’s performance.Materials and methodsWe compared four kits (miRNeasy Serum/Plasma, miRNeasy Mini Kit from Qiagen; RNA-isolation, and Absolutely-RNA MicroRNA Kit from Agilent technologies) for quality and quantity of microRNA isolated, extraction efficiency, and cost-effectiveness. Bioanalyzer-based Agilent Small RNA kit was used to evaluate quality and quantity of microRNA. Extraction efficiency was evaluated by detection of four endogenous control microRNA using real-time-PCR. Further, we modified the manufacturer’s protocol for miRNeasy Serum/Plasma kit to improve yield.ResultsmiRNeasy Serum/Plasma kit outperformed the other three kits in microRNA-quality (P < 0.005) and yielded maximum microRNA-quantity. Recovery of endogenous control microRNA i.e. hsa-miR-24-3p, hsa-miR-191-5p, hsa-miR-423-5p and hsa-miR-484 was higher as well. Modification with the inclusion of a double elution step enhanced yield of microRNA extracted with miRNeasy Serum/Plasma kit significantly (P < 0.001).ConclusionWe demonstrated that miRNeasy Serum/Plasma kit outperforms other kits and can be reliably used with a limited plasma quantity. We have provided a modified microRNA-extraction protocol with improved microRNA output for downstream analyses. 相似文献
15.
Nisha Arunatilake Priyanka Jayawardena 《International Journal of Educational Development》2010,30(1):44-53
Using the experience of the Educational Quality Inputs (EQI) Scheme in Sri Lanka the paper examines the distributional aspects of formula-based funding and efficiency of decentralized management of education funds in a developing country setting. The study finds that the EQI fund distribution is largely pro-poor. However, results show that to reduce disparities allocated funds need to be fully utilized. The findings of the study supports the hypothesis that qualified principals, adequate levels of human and physical resources and state level monitoring and support are needed for the success of education management at the school level. 相似文献
16.
Priyanka Surana Aarti Sankhla P. K. Dashora 《Indian journal of clinical biochemistry : IJCB》2000,15(2):167-170
To examine the effect of “DeepaniyaVati”, a herbal formulation in the management of hyperlipidemia, a randomized group pre-test
post-test study trial was carried out on fifty male (30 to 70 yrs) hyperlipidemic volunteers who were asked to follow their
normal routine diet and activity pattern throughout the investigation period. The formulation, prepared by mixing nine plant
products in equal proportion, when given in a daily dose of 2g, twice a day for a period of one month, brought about an observable
improvement in all the lipid parameters by significantly reducing total cholesterol (10%), low density lipoprotein cholesterol
(12.76%), very low density lipoprotein cholesterol (27.4%), triglycerides (34.7%) and bringing these values much nearer to
the normal levels. In control group, no such effect was noticed. A concomitant significant increase in the HDL-C levels suggests
the possible utility of “Deepaniya Vati” in the management of hyperlipidemia and the need for further detailed study. 相似文献
17.
To assess quantitatively the completeness and clarity of author guidelines of international English‐language journals in the biomedical and physical sciences, we randomly sampled 80 journals for which author guidelines were available online in English. The guidelines were reviewed for completeness and clarity in addressing ‘aims and scope’, ‘submission and post‐submission processes’, ‘formatting instructions’, ‘ethical requirements’, and ‘authorship’, and were subjectively assessed as being complete (score 1) or incomplete (0), and clear (1) or unclear (0). Scores were represented as mean percentages. No journal scored 100% for completeness and clarity. ‘Formatting instructions’ was the most complete and clear category, and ‘authorship’ the least complete and clear category. Biomedical science journals were more complete and clear in all categories, except ‘authorship‘, compared to physical science journals. While author guidelines of many English‐language journals of biomedical and physical sciences adequately address some essential aspects, they currently do not provide all necessary information as clearly as possible. 相似文献