Lipid abnormalities,lipoprotein (a) and apoprotein pattern in non-dialyzed patients with chronic kidney disease     

A. Madhusudhana Rao  A. R. Bitla  E. P. Reddy  V. Sivakumar  P. V. L. N. Srinivasa Rao 《Indian journal of clinical biochemistry : IJCB》2010,25(1):47-50

The present study was carried out to explore the altered lipid, lipoprotein and apoprotein abnormalities along with lipoprotein (a) in chronic kidney disease patients with stage I to V which were further divided into group 1 (stage I and II), group 2 (stage III and IV) and group 3 (stage V). 50 chronic kidney disease patients with stage I to V and 20 healthy normal subjects as controls were recruited for this study. Among the various parameters tested triglyceride levels were high in group 1 and 2, whereas VLDL cholesterol, Lp (a) and apo B levels were significantly high in all the groups when compared to controls (P<0.05). However, LDL cholesterol level was significantly low in group 3 only as compared to control group (P<0.05). Apoprotein AI values also showed significant decrease in all groups as compared to controls (P<0.05). Though total cholesterol levels in group 1 and LDL levels in group 1 and 2 were higher than controls, but the values attained not statistically significant (P>0.05). In conclusion high levels of VLDL cholesterol, Lp (a), apo B and low levels of apoprotein AI as reported in this study are the major lipid disorders in the development of cardiovascular complications at all the stages in these patients.  相似文献   

关于陕西基层公共图书馆古籍保护情况的调查研究     

翟淑君 《科技管理研究》2010,30(13)

通过对陕西基层公共图书馆古籍保护情况的系统调查,主要从人力资源、古籍保护与开发、专项资金三个方面全面了解陕西基层公共图书馆古籍保护的基本情况,在此基础上提出了加强陕西古籍保护和利用的几点意见,旨在对陕西的古籍保护事业有所帮助.  相似文献   

透析听毛细胞动作电位的形成原理——从2020年山东卷一道题谈起     

饶猛兵 《生物学教学》2022,(1)

本文通过对山东省2020年普通高中学业水平等级考试的一道疑似“错题”进行“拨乱反正”,解答部分师生对该题涉及的听毛细胞动作电位形成原理的疑惑。  相似文献   

以客户体验管理提升观众参观科技馆体验的思考——以中国科技馆为例          下载免费PDF全文

苑晓  饶荣亮  陈思思  薛珂 《自然科学博物馆研究》2024,(1):72-79

科技馆要成为观众喜爱的参观目的地,需要不断提升观众参观科技馆过程的体验。本文以中国科技馆为例,介绍科技馆开展客户体验管理的流程和方法:设定目标、梳理关键触点和驱动要素、采集数据、分析数据与改善行动、完善信息化平台。客户体验管理需要通过“采集数据—分析数据—改善行动”等步骤,精准改善各触点的观众体验,形成动态的改进机制,持续改善观众参观科技馆体验。希望本文能为致力于提升科普场馆观众参观体验的同行们提供一点启发,共同促进科普事业高质量发展。  相似文献   

Double lock of a potent human therapeutic monoclonal antibody against SARS-CoV-2     

Ling Zhu  Yong-Qiang Deng  Rong-Rong Zhang  Zhen Cui  Chun-Yun Sun  Chang-Fa Fan  Xiaorui Xing  Weijin Huang  Qi Chen  Na-Na Zhang  Qing Ye  Tian-Shu Cao  Nan Wang  Lei Wang  Lei Cao  Huiyu Wang  Desheng Kong  Juan Ma  Chunxia Luo  Yanjing Zhang  Jianhui Nie  Yao Sun  Zhe Lv  Neil Shaw  Qianqian Li  Xiao-Feng Li  Junjie Hu  Liangzhi Xie  Zihe Rao  Youchun Wang  Xiangxi Wang  Cheng-Feng Qin 《国家科学评论(英文版)》2021,8(3)

Receptor recognition and subsequent membrane fusion are essential for the establishment of successful infection by SARS-CoV-2. Halting these steps can cure COVID-19. Here we have identified and characterized a potent human monoclonal antibody, HB27, that blocks SARS-CoV-2 attachment to its cellular receptor at sub-nM concentrations. Remarkably, HB27 can also prevent SARS-CoV-2 membrane fusion. Consequently, a single dose of HB27 conferred effective protection against SARS-CoV-2 in two established mouse models. Rhesus macaques showed no obvious adverse events when administrated with 10 times the effective dose of HB27. Cryo-EM studies on complex of SARS-CoV-2 trimeric S with HB27 Fab reveal that three Fab fragments work synergistically to occlude SARS-CoV-2 from binding to the ACE2 receptor. Binding of the antibody also restrains any further conformational changes of the receptor binding domain, possibly interfering with progression from the prefusion to the postfusion stage. These results suggest that HB27 is a promising candidate for immuno-therapies against COVID-19.  相似文献   

基于智能学习工厂的实践教学体系探究——以智能制造工程专业为例     

张自强  陈树君 《高等工程教育研究》2022,(2):87-92

实践教学在工科专业的教学体系中占有重要地位，对于培养学生的创新精神与工程能力起到了不可替代的作用。然而，现有实践教学体系存在内容多呈碎片化、实践过程程式化、缺乏与应用高度融合、未能高效利用新技术等问题，从而难以满足社会需求。为此，以智能制造工程专业为例，结合制造岛概念，在校区范围内建立覆盖产品生产全流程的工业化、智能化、网络化、模块化智能学习工厂，并基于此建立实践教学体系，在实践环节构建、实践内容设置、实践手段运用、辅助措施建设等方面开展创新研究，使其具有前沿需求引导、工业特点突出、完整流程覆盖、内容主线明确、实践手段丰富的特点，以满足“新工科”形势下的人才培养需求。  相似文献