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51.
Sabrina Mattoli 《Journal of Zhejiang University. Science. B》2015,16(8):651-660
Bloodborne fibrocytes are cells mobilized from the bone marrow, which express surface antigens commonly ascribed to hematopoietic progenitors and have phenotypic and functional characteristics similar to those of immature mesenchymal cells. They exhibit predominant proinflammatory or profibrotic activities at tissue sites, depending on the host’s response to environmental insults and on the characteristics of the cell infiltrate and cytokine milieu. In patients with allergic asthma, fibrocytes egress from the bone marrow and are recruited into the airways after every allergen exposure and during viral infections. Recruited fibrocytes amplify the inflammatory responses driven by T helper type 2 lymphokines and favor viral replication and further inflammation on respiratory virus infections. Persistently elevated blood fibrocyte counts and persisting airway fibrocytosis are present in patients with chronically undertreated or corticosteroid-insensitive asthma, and are linked to an enhanced risk of adverse outcomes because of the major involvement of fibrocytes in the development of structural abnormalities that lead to chronic airflow obstruction in these patients. Consequently, blood fibrocyte count is an emerging biomarker of asthma control and disease progression and its clinical applicability as a new outcome measure deserves further evaluation in large clinical trials. 相似文献
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Developmental Trajectories of Acculturation: Links With Family Functioning and Mental Health in Recent‐Immigrant Hispanic Adolescents 
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下载免费PDF全文 Seth J. Schwartz Jennifer B. Unger Byron L. Zamboanga David Córdova Craig A. Mason Shi Huang Lourdes Baezconde‐Garbanati Elma I. Lorenzo‐Blanco Sabrina E. Des Rosiers Daniel W. Soto Juan A. Villamar Monica Pattarroyo Karina M. Lizzi José Szapocznik 《Child development》2015,86(3):726-748
The present study was designed to examine acculturative changes, and their effects on mental health and family functioning, in recent‐immigrant Hispanic adolescents. A sample of 302 Hispanic adolescents was assessed five times over a 2½‐year period. Participants completed measures of Hispanic and U.S. practices, collectivist and individualist values, and ethnic and U.S. identity at each time point. Baseline and Time 5 levels of mental health and family functioning were also assessed. Latent class growth analyses produced two‐class solutions for practices, values, and identifications. Adolescents who increased over time in practices and values reported the most adaptive mental health and family functioning. Adolescents who did not change in any acculturation domain reported the least favorable mental health and family functioning. 相似文献
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Effects of concurrent training on interleukin-6, tumour necrosis factor-alpha and C-reactive protein in middle-aged men 总被引：1，自引：1，他引：0
Libardi CA Souza GV Gáspari AF Dos Santos CF Leite ST Dias R Frollini AB Brunelli DT Cavaglieri CR Madruga VA Chacon-Mikahil MP 《Journal of sports sciences》2011,29(14):1573-1581
The purpose of this study was to evaluate the effects of moderate- to high-intensity resistance and concurrent training on inflammatory biomarkers and functional capacity in sedentary middle-aged healthy men. Participants were selected on a random basis for resistance training (n = 12), concurrent training (n = 11) and a control group (n = 13). They performed three weekly sessions for 16 weeks (resistance training: 10 exercises with 3 × 8-10 repetition maximum; concurrent training: 6 exercises with 3 × 8-10 repetition maximum, followed by 30 minutes of walking or running at 55-85% [Vdot]O(2peak)). Maximal strength was tested in bench press and leg press. The peak oxygen uptake ([Vdot]O(2peak)) was measured by an incremental exercise test. Tumour necrosis factor-α, interleukin-6 and C-reactive protein were determined. The upper- and lower-body maximal strength increase for both resistance (+42.52%; +20.9%, respectively) and concurrent training (+28.35%; +21.5%, respectively) groups (P = 0.0001).[Vdot]O(2peak) increased in concurrent training when comparing pre- and post-training (P = 0.0001; +15.6%). No differences were found in tumour necrosis factor-α and interleukin-6 for both groups after the exercise. C-reactive protein increased in resistance training (P = 0.004). These findings demonstrated that 16 weeks of moderate- to high-intensity training could improve functional capacity, but did not decrease inflammatory biomarkers in middle-aged men. 相似文献
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The source of renewal of instrumental responding in rats was investigated. In Experiment 1, two responses (R1 and R2) were reinforced with one outcome (O1) in contexts A and B (i.e., R1→O1, R2→O1), and then R2 was extinguished in A and R1 was extinguished in B. At test, the rate of R1 was higher than that of R2 in context A, and the reverse was the case in context B: Renewed responding was independent of the Pavlovian context→O1 associations. In Experiment 2, all rats received R1→O1 and R2→O2 trials in A and then were placed in B, where they were sated on O2 and either did (Group Extinction) or did not (Group No Extinction) receive concurrent extinction of R1 and R2. At test, we found more responding in A than in B for Group Extinction, but not for Group No Extinction, and the renewed responding in A was as sensitive to the current value of the outcome as responding that had not been subject to extinction (i.e., the rate was higher for R1 than for R2). That is, the renewed responding was goal-directed. These results identify the removal of contextual inhibion of either the response or the response→outcome associaon as potenal bases for renewal, and the response→outcome associaon as the source of renewed responding. 相似文献
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Sabrina Germain 《Journal of Criminal Justice Education》2013,24(2):196-209
This article presents how unconventional teaching environments, such as the prison system, can participate in the elaboration of new pedagogical methods and, in the process, reveal the diverse responses of marginalized groups to the study of the law. Over the course of this article, I provide valuable insight about underexplored teaching techniques to academics seeking to open up their approach beyond traditional methods. Through this partially reflective piece, I relay my experience as a law instructor in a maximum security prison, and demonstrate how those who have bore the brunt of the law can still think critically about legal topics. I also support the idea that by taking in the perspectives of peripheral groups, legal educators will be led to use innovative methods to deliver legal knowledge. Essentially this article explores the intersection between legal pedagogy and the prison system to uncover a site previously neglected by conventional work on criminology and education. Pointing out how experiencing the law differently can shape individual interpretations of legal knowledge, I hope to situate learning within a larger criminological process. 相似文献
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Childbirth education for multiple pregnancy: part 2: intrapartum and postpartum considerations 下载免费PDF全文
下载免费PDF全文 Montgomery KS Cubera S Belcher C Patrick D Funderburk H Melton C Fastenau M 《The Journal of perinatal education》2005,14(3):33-38
Women with a multiple pregnancy can expect a different labor and birth course than those with a singleton pregnancy. While the postpartum period is similar to that of families with a singleton, it is likely to be more hectic in families with multiple infants. In addition, a multiple pregnancy increases both maternal and neonatal risks; therefore, women with a multiple pregnancy may experience slight differences in care due to these potential risks, including additional monitoring and treatment. This article discusses the intrapartum and postpartum considerations families with a multiple pregnancy/birth may experience. This information is provided so that the childbirth educator can incorporate this content into courses, as appropriate, and assist families with a multiple pregnancy to anticipate a realistic birth and postpartum experience. 相似文献
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Sabrina F. Sembiante Traci P. Baxley Christina J. Cavallaro 《Diaspora, Indigenous, and Minority Education》2018,12(1):28-41
This article investigates how immigrant children’s acculturation experiences are characterized through the symbolic literary feature of name in children’s literature and how the language of the text functions to communicate these messages. We draw on the theoretical frameworks of Critical Literacy (CL) and Systemic Functional Linguistics (SFL) to inform our analysis, showcasing how the connection and interrelation of these theories maximizes the potential for meaning-making. Texts were examined to reveal dominant themes around acculturation communicated through the use of protagonists’ names and trends in the language used to construct young readers’ understandings. Findings indicate that the construct of a name is a key theme in the literature used to forge a cultural identity for immigrant children, generate cultural conflict, and stimulate others’ judgment. 相似文献
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Carmen De Maio Giuseppe Fenza Vincenzo Loia Sabrina Senatore 《Information processing & management》2012
In recent years, knowledge structuring is assuming important roles in several real world applications such as decision support, cooperative problem solving, e-commerce, Semantic Web and, even in planning systems. Ontologies play an important role in supporting automated processes to access information and are at the core of new strategies for the development of knowledge-based systems. Yet, developing an ontology is a time-consuming task which often needs an accurate domain expertise to tackle structural and logical difficulties in the definition of concepts as well as conceivable relationships. This work presents an ontology-based retrieval approach, that supports data organization and visualization and provides a friendly navigation model. It exploits the fuzzy extension of the Formal Concept Analysis theory to elicit conceptualizations from datasets and generate a hierarchy-based representation of extracted knowledge. An intuitive graphical interface provides a multi-facets view of the built ontology. Through a transparent query-based retrieval, final users navigate across concepts, relations and population. 相似文献