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31.
Santosh Kumar Maurya Kanwal Raj Arvind Kumar Srivastava 《Indian journal of clinical biochemistry : IJCB》2009,24(4):404-409
The root of Glycyrrhiza glabra is a traditional medicine used mainly for the treatment of peptic ulcer, hepatitis C, pulmonary
and skin diseases, although clinical and experimental studies suggest that it has several other useful pharmacological properties
such as antiinflammatory, antiviral, antimicrobial, antioxidative, anticancer activities, immunomodulatory, hepatoprotective
and cardioprotective effects. Glycyrrhizinic acid, a major component of licorice, has antiulcer effect by raising the local
concentration of prostaglandins that promote mucous secretion and cell proliferation in the stomach. Glycyrrhizin shows hepatoprotective
effect by preventing changes in cell membrane permeability, inhibiting phospholipase A2 (PLA2) and increasing survival rate of hepatocytes. Glabridin has effect in melanogenesis and inflammation by inhibiting the tyrosinase
activity of melanocytes. α-glycyhrritinic acid exhibits anti-inflammatory activity by inhibiting glucocorticoid metabolism.
In present study ethanolic (95%) extract of root of Glycyrrhiza glabra and its fractions were investigated for its antidyslipidaemic
activity on HFD induced dyslipidaemic hamsters. Ethanolic extract and its ethyl acetate soluble, water soluble and hexane
soluble fractions decreased serum level of total cholesterol by 25.9, 38.0, 39.0 and 26.3%, respectively. On the other hand
ethanolic extract, ethyl acetate soluble, water soluble and hexane soluble fraction increased the serum HDL-cholesterol level
by 14.8, 34.3, 27.3 and 17.2%, respectively. Ethanolic extract, ethyl acetate fraction, aqueous fraction and hexane fraction
decreased triglyceride level by 31.3, 37.2, 41.2 and 28.9%, respectively. The reduction in LDL-cholesterol level by ethanolic
extract, ethyl acetate soluble fraction and water soluble fraction were 43.9, 31.0, 33.4 and 24.6%, respectively. 相似文献
32.
The paper presents some findings of a study which surveyed the political attitudes and involvement of American scientists.We found an unambiguous rank ordering based on political orientation among the various subgroups of scientists. The greater the scientists' identification with basic science and the university, the greater the liberalism. However, the claim that scientific elites are more liberal than the rank-and-file and that physicists are the most liberal among natural scientists was not substantiated.The fear that a scientific-technological elite might become a dominant political elite was not reflected in the thinking of a large majority of our 1205 respondents. A majority expressed reservations about the skill and knowledge of the citizenry to understand and resolve the increasingly complex problems of our society, recognize that a separation of science and politics is not attainable or even desireable, but remain somewhat uneasy with the new situation in which their work has become so enmeshed with policy concerns.The traditional norm system of science continues to receive substantial support and takes precedence over either the concern about the social consequences of certain types of “dangerous” knowledge, or the costs that heavy investments in basic science involve. We find that scientists are largely prepared to sacrifice the norm of communality at the altar of nationalism. The clash between an internal ideology of science that values disinterested search for knowledge and an external ideology of society which focuses on utility presents a continuing dilemma. 相似文献
33.
Abstract This paper aims to examine the strategies, mechanisms and practices of local level water use negotiation. The paper reveals that local people have their own strategies, mechanisms and approaches to utilise available limited natural resources. The case of water‐use negotiation was studied using direct observation, group discussion and interview methods. The paper explores the effect of norms, values, beliefs, knowledge, power, communication and facilitation, feelings of ownership on resources use negotiation and water‐resource management processes in Nepal. Women are the crucial actors and dynamic negotiators of community level resource use conflict. The role of development organisations is identified as facilitators to resolve conflict instead of leading the negotiation. The dominant extension approach in Nepal is not able to address resource use conflict. It needs an approach that acknowledges conflict as a part of social process and that promotes the facilitation of negotiation and adaptation. 相似文献
34.
Saravanan Raj 《The Journal of Agricultural Education and Extension》2013,19(2):113-131
Abstract Purpose: This case study deals with the implementation methodology, innovations and lessons of the ICT initiative in providing agricultural extension services to the rural tribal farming community of North-East India. Methodology: This study documents the ICT project implementation challenges, impact among farmers and briefly indicates lessons of the e-agriculture project. Findings: The e-agriculture prototype demonstrated that the Rs. 2,400 (USD 53) cost of the extension services to provide farm advisory services was saved per farmer per year, expenditure was reduced 3.6 times in comparison with the conventional extension system. Sixteenfold less time was required by the farmers for availing the services and threefold less time was required to deliver the services to the farmers compared with the conventional extension system. However, this article argues that in less developed areas, information through ICTs alone may not create expected development. Along with appropriate agricultural information and knowledge, field demonstrations and forward (farm machinery, manure, seeds) and backward linkages (post-harvest technology and market) need to be facilitated with appropriate public–private partnership between knowledge and other rural advisory service providers for agricultural development. Practical implications: This article lists a number of practical lessons which will be useful for the successful planning and implementation of e-agriculture projects in developing countries. Original value: This article is a first case study on ICTs for agricultural extension initiatives among the tribal farmers who dominate the less developed North-East India. 相似文献
35.
Vishnu Kumar Farzana Mahdi Ashok Kumar Khanna Ranjana Singh Ramesh Chander Jitendra Kumar Saxena Abbas Ali Mahdi Raj Kumar Singh 《Indian journal of clinical biochemistry : IJCB》2013,28(1):46-50
The antidyslipidemic activity of Hibiscus rosa sinensis (Malvaceae) root extract has been studied in alloxan induced diabetic rats. In this model, oral administration of root extract (500 mg/kg bw. p.o.) for 15 days resulted in significant decreased in the levels of blood glucose, plasma lipids and reactivated post heparin lipoprotein lipase activity in alloxan induced diabetic rats. Furthermore, the root extract (50–500 μg) when tested for its antioxidant activity, inhibited the generation of super oxide anions and hydroxyl radicals, in both enzymic and non enzymic systems in vitro. The results of the present study demonstrated antidyslipidemic and antioxidant activities in root extract of H. rosa sinensis which could be used in prevention of diabetic-dyslipidemia and related complications. 相似文献
36.
This article focuses on the different components that make up Ziegler–Natta olefin polymerization systems and shows how investigating the interactions between these components through computational approaches provide crucial information about the chemistry of these systems. Hence, the necessity of theory acting as a counterpoint to experiment is revealed, underlining the importance of computational chemistry in attacking important problems of the day. 相似文献
37.
A formulation and solution scheme of free final time fractional optimal control problems is presented in this paper. The dynamic constraint is described by a fractional differential equation. Performance index considered is a function of both the state and control variables. The necessary conditions of optimality and the transversality condition are obtained using Lagrange multiplier technique. A numerical technique similar to Shooting method is used for solving the optimal conditions. Numerical example is provided to show the effectiveness of the formulation and numerical solution scheme. It is interesting to note that the final time changes with the interchange of the boundary conditions, which does not occur in classical optimal control problems. 相似文献
38.
Raj Kumar Bhardwaj 《The Reference Librarian》2014,55(1):74-88
The study investigates how library and information science professionals working in higher education institutions in India integrate social networking sites (SNS) into their routine work. It was revealed through the questionnaire that the majority of respondents are members of the institution's official group on the SNS, whereas only one fifth are members of an unofficial student group. These information professionals use SNS to socialize, keep themselves up-to-date, find jobs, and acquire information about conferences and seminars in their respective fields. Some of the legitimate concerns of library and information science professionals are privacy and cyberbullying. To increase use, social networking applications must be incorporated into the curriculum of master's degree courses for library and information science. 相似文献
39.
Managing a whole body donor program is necessary for facilitating a traditional dissection‐based anatomy curriculum in medicine and health sciences. Factors which influence body donations to medical science can therefore affect dissection‐based anatomy teaching. In order to determine whether age influences the attitudes of medical students to donations, this study surveyed, by Likert‐type questionnaires, first‐year graduate‐entry medical students attending a dissection‐based anatomy course. In contrast to attitudes among younger traditional‐entry medical students, initial support for whole body donation by an unrelated stranger (83.8%), a family member (43.2%) or by the respondent (40.5%) did not decrease among graduate‐entry medical students after exposure to dissection although there was a significant shift in strength of support for donation by stranger. This suggests that older medical students do not readily modify their pre‐established attitudes to the idea of whole body donation after exposure and experience with dissection. Initial ambivalence among respondents to the idea of donation by family member was followed by opposition to this type of donation. These findings demonstrate that age modulates the influences on a priori attitudes to whole body donation that exposure to dissection causes in younger medical students. Anat Sci Educ 2:167–172, 2009. © 2009 American Association of Anatomists. 相似文献
40.
Raj K. Pan Alexander M. Petersen Fabio Pammolli Santo Fortunato 《Journal of Informetrics》2018,12(3):656-678
Scientific production is steadily growing, exhibiting 4% annual growth in publications and 1.8% annual growth in the number of references per publication, together producing a 12-year doubling period in the total supply of references, i.e. links in the science citation network. This growth has far-reaching implications for how academic knowledge is connected, accessed and evaluated. Against this background, we analyzed a citation network comprised of 837 million references produced by 32.6 million publications over the period 1965–2012, allowing for a detailed analysis of the ‘attention economy’ in science. Our results show how growth relates to ‘citation inflation’, increased connectivity in the citation network resulting from decreased levels of uncitedness, and a narrowing range of attention – as both very classic and very recent literature are being cited increasingly less. The decreasing attention to recent literature published within the last 6 years suggests that science has become stifled by a publication deluge destabilizing the balance between production and consumption. To better understand these patterns together, we developed a generative model of the citation network, featuring exponential growth, the redirection of scientific attention via publications’ reference lists, and the crowding out of old literature by the new. We validate our model against several empirical benchmarks, and then use perturbation analysis to measure the impact of shifts in citing behavior on the synthetic system's properties, thereby providing insights into the functionality of the science citation network as an infrastructure supporting the memory of science. 相似文献