Microalbuminuria in Obese Young and Middle Aged Population: A Potential Marker of Cardiovascular Risk     

Purvi Purohit  Kunal Garg  Vikram Singh  Shailendra Dwivedi  Praveen Sharma 《Indian journal of clinical biochemistry : IJCB》2016,31(3):349-352

Microalbuminuria is an established cardiovascular risk indicator in diabetes, hypertension and the general population. There is lack of information on MAU in healthy obese Indian adults and an ongoing debate whether obese adults deserve targeted identification and clinical intervention for MAU and prediabetes. We aimed to screen the healthy obese, young (group I) and middle aged (group II) adults for prevalence of MAU and prediabetes and study its association with Framingham risk score. The study included 50 healthy obese young (20–30 years) and middle aged adults (31–50 years), attending the outpatient clinic of Dept. of Medicine for a duration of 2 months (July–August). The patients were screened for fasting blood sugar, lipid profile and MAU. Of the total patients 28 % had MAU, 32.14 % of which had prediabetes and 33.33 % had diabetes whereas 10 % were normoglycemic. The group I patients had 50 % cases of MAU and group II had 25 % patients with MAU. Group II 63.63 % pre-diabetics. The values of MAU obtained were correlated with age, gender, body mass index, systolic and diastolic blood pressure, FBS, waist to hip ratio using Pearson’s Coefficient (p < 0.05). The 10 year CVD risk calculated using FRS in subjects with MAU was higher as compared to those without MAU. Thus we conclude that Indian, young and middle aged obese adults to be at a risk of prediabetes, MAU and CV risk warranting their routine screening for better clinical outcomes.  相似文献   

Doctoral students’ experiences of nondisclosure with their dissertation chair     

Ryan M. Cook  Rachel Crabtree  Corrine R. Sackett  Andrea Baylin  Jyotsana Sharma 《Counselor Education & Supervision》2023,62(1):64-79

We examined doctoral students’ experiences of nondisclosure with their dissertation chairs. Using a hermeneutic phenomenology design, we analyzed two individual interviews of 10 doctoral students. We identified the following three themes: (a) the professional dynamics in the relationship, (b) the interpersonal and cultural dynamics in the relationship, and (c) prioritization of completing the dissertation. Implications for doctoral students and dissertation chairs are discussed.  相似文献   

A system-wide professional learning approach about inclusion for teachers in Hong Kong     

Chris Forlin  Tim Loreman  Umesh Sharma 《Asia-Pacific Journal of Teacher Education》2014,42(3):247-260

This study examines changes in attitudes, teaching efficacy, and concerns about inclusive education in a sample of 2361 teachers in Hong Kong who took a professional learning course about inclusive education. Participants completed a questionnaire seeking demographic information and their perceptions about these three aspects of inclusive education both before and after their course. Items were selected from the Sentiments, Attitudes, and Concerns about Inclusive Education Scale Revised and Teacher Efficacy for Inclusive Practices scales that were of relevance to the objectives of this study. The results indicate that in all three areas of acceptance, teaching efficacy, and concerns about inclusive education, positive improvements were made as a result of training, although generally this improvement was strongest in areas that teachers felt were under their direct control. The small amount of change in areas that teachers felt were not under their control may indicate that whatever change initiatives are put in place, they need to be holistic and systemic.  相似文献   

Alkaline Phosphatase: An Overview     

Ujjawal Sharma  Deeksha Pal  Rajendra Prasad 《Indian journal of clinical biochemistry : IJCB》2014,29(3):269-278

Alkaline phosphatase (ALP; E.C.3.I.3.1.) is an ubiquitous membrane-bound glycoprotein that catalyzes the hydrolysis of phosphate monoesters at basic pH values. Alkaline phosphatase is divided into four isozymes depending upon the site of tissue expression that are Intestinal ALP, Placental ALP, Germ cell ALP and tissue nonspecific alkaline phosphatase or liver/bone/kidney (L/B/K) ALP. The intestinal and placental ALP loci are located near the end of long arm of chromosome 2 and L/B/K ALP is located near the end of the short arm of chromosome 1. Although ALPs are present in many mammalian tissues and have been studied for the last several years still little is known about them. The bone isoenzyme may be involved in mammalian bone calcification and the intestinal isoenzyme is thought to play a role in the transport of phosphate into epithelial cells of the intestine. In this review, we tried to provide an overview about the various forms, structure and functions of alkaline phosphatase with special focus on liver/bone/kidney alkaline phosphatase.  相似文献   

Metabolic Issues in Schizophrenic Patients Receiving Antipsychotic Treatment     

Aditi Gupta  Gora Dadheech  Dharamveer Yadav  Praveen Sharma  Shiv Gautam 《Indian journal of clinical biochemistry : IJCB》2014,29(2):196-201

Schizophrenia is a psychotic disorder with a complex pathophysiology and requires treatment that includes long term administration of antipsychotics that is said to be associated with metabolic syndrome. This study was designed to evaluate the impact of seven different antipsychotics prescribed to schizophrenic patients, on development of metabolic syndrome in the patients. A total of 210 patients with schizophrenia (30 patients in each drug therapy group) were recruited according to ICD-10 criteria and were assigned to receive the drug for 16 weeks. Measurement of anthropometric (body weight, waist circumference, blood pressure) and biochemical parameters (glucose, insulin, HOMA-IR, triglycerides, LDL, HDL) was done and the patients were subjected to ATP-III defined criteria for metabolic syndrome. Patients undergoing treatment with olanzapine were more prone to metabolic syndrome as the drug induces weight gain after 16 weeks of treatment. It also induces dyslipidemia (P < 0.001) and hyperglycemia (P < 0.01). Clozapine was found to be second most potent drug in inducing metabolic syndrome as the weight in clozapine treated patients increased after 16 weeks, along with a significant increase in glycemic (P < 0.001) and lipid parameters (P < 0.01). Aripriazole and amisulphride are comparatively safer drugs as their role in inducing metabolic abnormalities in schizophrenic patients was insignificant, although the impact of long term administration of these drugs needs to be explored. It is clear from the study that antipsychotic treatment induces metabolic syndrome so, it becomes important that the metabolic and cardiovascular risk factors should be surveillance regularly in schizophrenic patients undergoing antipsychotic treatment.  相似文献   

澳大利亚的融合教育支持体系——维多利亚州的模式     

刘鲲  杨广学  Umesh Sharma 《中国特殊教育》2012,(9):13-17

本文以维多利亚州为例,概括、分析了澳大利亚融合教育的法律、政策框架和发展趋势,分析了维多利亚州以“教和学”为核心的服务体系、“一体化”的融合教育服务模式和跨学科的专业服务模式,讨论了融合教育发展与普通教育体系变革之间的深刻联系.  相似文献   

Book reviews     

Dev Sharma  Kate Pike  Christine Williams  Irene Broadley  Barbara Hughes  Susan Billington 《Educational Psychology in Practice》2008,24(4):355-366

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On-chip microelectrode impedance analysis of mammalian cell viability during biomanufacturing     

Rachita Sharma  Tobias Blackburn  Weiwei Hu  Kelly Wiltberger  Orlin D. Velev 《Biomicrofluidics》2014,8(5)

The characterization of cell viability is a challenging task in applied biotechnology, as no clear definition of cell death exists. Cell death is accompanied with a change in the electrical properties of the membrane as well as the cell interior. Therefore, changes in the physiology of cells can be characterized by monitoring of their dielectric properties. We correlated the dielectric properties of industrially used mammalian cells, sedimented over interdigitated microelectrodes, to the AC signal response across the chip. The voltage waveforms across the electrodes were processed to obtain the circuit impedance, which was used to quantify the changes in cell viability. We observed an initial decrease in impedance, after which it remained nearly constant. The results were compared with data from the dye exclusion viability test, the cell specific oxygen uptake rate, and the online viable cell density data from capacitance probes. The microelectrode technique was found to be sensitive to physiological changes taking place inside the cells before their membrane integrity is compromised. Such accurate determination of the metabolic status during this initial period, which turned out to be less well captured in the dye exclusion tests, may be essential for several biotechnology operations.  相似文献   

Correction to: Combined Analysis of Anti SARS-CoV-2 IgG and IgM Responses in COVID19 Patients in India     

Mohana Kumari Chidananda  Deepy Zohmangaihi  Sant Ram  Shiv Lal Vikas SoniSuri  Pankaj Malhotra  Ravjit Singh Jassal  Jyotdeep Kaur  Indu Verma  Sadhna Sharma 《Indian journal of clinical biochemistry : IJCB》2021,36(4):501

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Screening of field pea （Pisum sativum） selections for their reactions to root-knot nematode （Meloidogyne incognita）     

Sharma A  Haseeb A  Abuzar S 《Journal of Zhejiang University. Science. B》2006,7(3):209-214

INTRODUCTION Fieldpea (Pisum sativum L.) is one of the im-portant pulse crops of the world and is cultivated over 5.9 million hectares with a production of about 11.7 million tons (Singh, 1983). In India it is grown over 0.7 million hectares yielding about 0.6 million tons (Singh, 1983). Among various obstacles in cultivating this crop, root-knot nematode Meloidogyne incognita (Kofoid & White) Chitwood has been reported to cause severe yield losses of up to 20%~33% (Upadhyay and Dwiv…  相似文献