Erratum to: Linear Analysis of Autonomic Activity and Its Correlation with Creatine Kinase-MB in Overt Thyroid Dysfunctions     

Manisha Mavai  Yogendra Raj Singh  R. C. Gupta  Sandeep K. Mathur  Bharti Bhandari 《Indian journal of clinical biochemistry : IJCB》2018,33(2):229-230

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Evaluation of hypoglycemic and antioxidant effect of<Emphasis Type="Italic">Ocimum sanctum</Emphasis>     

Jyoti Sethi  Sushma Sood  Shashi Seth  Anjana Talwar 《Indian journal of clinical biochemistry : IJCB》2004,19(2):152-155

Ocimum sanctum leaves have been traditionally used in treatment of diabetes mellitus. Dietary supplementation of fresh tulsi leaves in a dose of 2 gm/kg BW for 30 days led to significant lowering of blood glucose levels in test group. Intake ofOcimum sanctum also led to significant increase in levels of superoxide dismutase, reduced glutathione and total thiols, but marked reduction in peroxiodised lipid levels as compared to untreated control group. The leaves were found to possess both superoxide and hydroxyl free radical scavenging action. The present observations establish the efficacy ofOcimum sanctum leaves in lowering blood glucose levels and antioxidant property appears to be predominantly responsible for hypoglycemic effect.  相似文献   

Oxygen derived free radicals in clinical context     

V. K. Gupta  V. Mallika  Yashika Gupta  D. K. Srivastava 《Indian journal of clinical biochemistry : IJCB》1992,7(1):3-10

Oxygen derived free radicals have been implicated in a number of clinical disorders including atherosclerosis (1), ischemic heart disease (IHD) (2), post ischemic reperfusion injury (3) and respiratory distress syndrome (4). These radical are generated by sequential reduction of molecular oxygen; the primary product being superoxide anion (O₂ ^.−) which is subsequently reduced to hydrogen peroxide (H₂O₂), hydroxy1 radical (OH^.) and singlet oxygen (¹O₂). However the evidence for ODFR induced cell damage in various clinical disorders is still debated and rests largely on free radical scavenging studies, through electron paramagnetic resonance spectroscopic (EPRS) studies have provided direct evidence for ODFR generation following coronary artery ligation (5). By definition, a free radical is an atom, ion or molecule with one or more unpaired electrons (the presence of unpaired electron in a free radical being represented by a superscribed bold dot-R^.) and may be formed as a result of homolytic fission of a covalent bond or by electron transfer reactions, and may have cationic (NH₃ ⁺), anionic (O₂ ^.−) or neutral (NO) characteristics. The most important in vivo source for these radical species have been found to be univalent biochemical redox reactions involving oxygen. (a) A:B→A^.+B^. (b) A:+B→A^.+B^.  相似文献   

Myasthenia gravis with thymoma presenting with thyrotoxicosis     

D. K. Srivastava  V. K. Gupta  M. Gupta  V. Malika 《Indian journal of clinical biochemistry : IJCB》1993,8(1):75-75

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Discrimination‐Related Stress Effects on the Development of Internalizing Symptoms Among Latino Adolescents          下载免费PDF全文

Selcuk R. Sirin  Lauren Rogers‐Sirin  Jessica Cressen  Taveeshi Gupta  Sammy F. Ahmed  Alfredo D. Novoa 《Child development》2015,86(3):709-725

This three‐wave longitudinal study of 173 Latino adolescents (M = 16.16 years, SD = 0.65) is designed to understand the role of discrimination‐related stress in mental health trajectories during middle to late adolescence with attention to differences due to immigration status. The results of the growth curve analysis showed that anxious‐depressed, withdrawn‐depressed, and somatic complaints significantly decreased over time. Furthermore, although discrimination‐related stress was found to be significantly related to the trajectories of three types of mental health symptoms, the results revealed that immigration status moderated these relations such that discrimination‐related stress was significantly related to these outcomes for Latino youth whose parents were born in the United States, while this relation was not significant for Latino children of immigrants.  相似文献   

Conditional convergence of nonresident tuition rates at public research universities: a panel data analysis     

Marvin A. Titus  Adriana Vamosiu  Anubha Gupta 《Higher Education》2015,70(6):923-940

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Kinetic analysis of LDL oxidation in IHD and IHD risk subjects in Indian population     

Yashika Gupta  V. Mallika  D. K. Srivastava 《Indian journal of clinical biochemistry : IJCB》2003,18(1):35-45

High plasma concentration of low-density lipoprotein (LDL) is associated with increased risk of atherosclerosis. Modified forms of LDL, especially oxidized LDL play a major role in its pathogenesis. This article gives detailed insight into the kinetics ofin vitro LDL oxidation by copper at different concentrations in normal and high-risk group subjects. Basal level of oxidatively modified LDL was significantly higher in ischaemic heart disease (IHD) and IHD hyperlipidemic subjects compared to normolipidemic and, hyperlipidemic control subjects, respectively. Derivatization of amino groups of apo-lipoprotein as monitored by estimating free amino groups concentration, was significantly higher in high-risk group and established IHD cases. Kinetics of oxidation was studied with two different concentrations of CuSO₄ (2.5 mM and 7.5 mM). thiobarbituric acid reactive substances (TBARS) level increases with time, and up to 95% oxidation was observed in 8 hr. About 60–65% less free amino groups were observed in native-LDL isolated from IHD patients compared to normal subjects. Study also showed an increase in two oxidative products studied, 20α-OH-cholesterol and 4-cholesten-3-one with oxidation time accompanied by corresponding decrease in LDL cholesterol. Increase in oxidative species was more evident in high-risk group and IHD patient. Basal level of oxidatively modified LDL measured in terms of TBARS was significantly higher in present study, strongly support that the extent of LDL oxidation monitored as TBARS and FAG level in circulating-LDL could be used as risk marker for high risk group.  相似文献   

Pro-oxidant and anti-oxidant status in patients of sickle cell anaemia     

Jyoti Titus  Suresh Chari  Madhur Gupta  Nitin Parekh 《Indian journal of clinical biochemistry : IJCB》2004,19(2):168-172

The role of oxidant damage to red cells in sickle cell anaemia has been of interest in recent years. Although, available reports suggest that sickle cell erythrocytes are susceptible to endogenous free radical mediated oxidant damage there remains discrepancy in the status of antioxidant enzymes and antioxidant vitamins in these patients. In view of this, 107 cases of sickle cell anaemia (36 ‘SS’ and 71 ‘AS’ pattern—as confirmed by haemoglobin electrophoresis) were subjected to analysis of malondialdehyde, ascorbic acid, superoxide dismutase and albumin. The results were compared with 54 age and sex matched healthy controls. The results indicate a marked increase in lipid peroxidation and superoxide dismutase levels in both ‘SS’ and ‘AS’ types of sickle cell anaemia as compared to controls. Although no difference was observed in the levels of albumin in these groups the levels of ascorbic acid were significantly depleted in sickle cell anaemia patients. The results are indicative of enhanced lipid peroxidation along with imbalance in the pro-oxidant and antioxidant status in patients of sickle cell anaemia.  相似文献   

Noise and fluctuations in electronic devices and circuits: F. N.H. Robinson. 246 pages,diagrams, 6×9 in. Oxford,England, Clarendon Press, 1974. Price, $27.25.     

Madhu S. Gupta 《Journal of The Franklin Institute》1977,303(2):220-221

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Hypoxia-Induced Inflammatory Chemokines in Subjects with a History of High-Altitude Pulmonary Edema     

K. P. Mishra  Navita Sharma  Poonam Soree  R. K. Gupta  Lilly Ganju  S. B. Singh 《Indian journal of clinical biochemistry : IJCB》2016,31(1):81-86

High altitude hypoxia is known to induce an inflammatory response in immune cells. Hypoxia induced inflammatory chemokines may contribute to the development of high altitude pulmonary edema (HAPE) by causing damage to the lung endothelial cells and thereby capillary leakage. In the present study, we were interested to know whether chronic inflammation may contribute to HAPE susceptibility. We examined the serum levels of macrophage inflammatory protein-1α (MIP-1α), monocyte chemoattractant protein-1 (MCP-1) and interleukin-8 in group (1) HAPE Susceptible subjects (n = 20) who had past history of HAPE and group (2) Control (n = 18) consist of subjects who had stayed at high altitude for 2 years without any history of HAPE. The data obtained confirmed that circulating MCP-1, MIP-1α were significantly upregulated in HAPE-S individuals as compared to the controls suggestive of chronic inflammation. However, it is not certain whether chronic inflammation is cause or consequence of previous episode of HAPE. The moderate systemic increase of these inflammatory markers may reflect considerable local inflammation. The existence of enhanced level of inflammatory chemokines found in this study support the hypothesis that subjects with past history of HAPE have higher baseline chronic inflammation which may contribute to HAPE susceptibility.  相似文献