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111.
112.
Manjima Dhar Jessica Wong Armin Karimi James Che Corinne Renier Melissa Matsumoto Melanie Triboulet Edward B. Garon Jonathan W. Goldman Matthew B. Rettig Stefanie S. Jeffrey Rajan P. Kulkarni Elodie Sollier Dino Di Carlo 《Biomicrofluidics》2015,9(6)
Circulating tumor cells (CTCs) are important biomarkers for monitoring tumor dynamics and efficacy of cancer therapy. Several technologies have been demonstrated to isolate CTCs with high efficiency but achieve a low purity from a large background of blood cells. We have previously shown the ability to enrich CTCs with high purity from large volumes of blood through selective capture in microvortices using the Vortex Chip. The device consists of a narrow channel followed by a series of expansion regions called reservoirs. Fast flow in the narrow entry channel gives rise to inertial forces, which direct larger cells into trapping vortices in the reservoirs where they remain circulating in orbits. By studying the entry and stability of particles following entry into reservoirs, we discover that channel cross sectional area plays an important role in controlling the size of trapped particles, not just the orbital trajectories. Using these design modifications, we demonstrate a new device that is able to capture a wider size range of CTCs from clinical samples, uncovering further heterogeneity. This simple biophysical method opens doors for a range of downstream interventions, including genetic analysis, cell culture, and ultimately personalized cancer therapy. 相似文献
113.
Carmen Wong Ulrich 《英语沙龙》2014,(1)
正不知不觉中,"二手货"的定义早已悄悄发生了变化,这也源于人们观念的转变——曾经的二手货陈旧、单调,是旧货的代名词;而如今的二手货则被赋予了全新的概念:闲置品、奢侈品、收藏品成为了二手货市场的主力军。由于购买二手货不光省钱,而且"绿色、环保",因此这种消费方式也逐渐成为了一种时尚,影响着人们生活的方方面面。如何才能淘到二手好货?购买二手货时应该注意什么?看看我们为你提供的建议吧! 相似文献
114.
In this study, we investigated-secondary school students’ perceptions of their constructivist learning environment in Liberal Studies, and whether their perceptions were related to their critical thinking ability. A convenience sample of Secondary Three students (N = 967) studying Liberal Studies in Hong Kong participated in this research by completing a self-administered questionnaire which included the Constructivist Learning Environment Survey (CLES), Cornell Critical Thinking Test Level X, and demographic information on age and gender. Students perceived their learning environment to be moderately constructivist in nature. Both age and school banding differences were identified in that younger students and students in band 1 schools tended to perceive a higher degree of constructivist characteristics in their learning environment. Multiple regression analyses indicated that three of the five scales of CLES were predictors of critical thinking ability. Shared Control was the strongest predictor and negatively associated with critical thinking ability, while Personal Relevance and Critical Voice were positively related to critical thinking ability. Findings of the study are discussed with reference to developing students’ critical thinking ability in Liberal Studies classrooms. 相似文献
115.
Excessive foot pronation is a risk factor of running injuries and motion control footwear is designed to control foot pronation. With the movement transfer between foot pronation and tibial rotation, motion control footwear may not only be confined to controlling foot pronation. In view of the controversies in the literature on effectiveness of motion control footwear, this paper reviewed the efficacy of motion control footwear functions as reported in the literature. Eligible studies were identified from seven electronic databases. Two independent authors extracted the data and assessed the methodological qualities using the Jadad Scale. A total of 14 quasi randomised controlled trials were included. Even though the included studies were rated as "low quality" according to the Jadad Scale, the data were pooled and analysed. Results revealed that motion control footwear was effective in reducing the amount of foot pronation and the peak vertical impact during landing. There is no evidence that suggests motion control footwear for controlling kinematics of the proximal segments. 相似文献
116.
From 1986 to 1988, Regional Centre for Education in Science and Mathematics (RECSAM) at Penang organised the Computers in Education Project with financial support from the Australian Government. The aim of the Project was to provide information on the use of computers in education among SEAMEO countries. Such information, it was thought, could be useful for educators who needed to formulate sound policies regarding the introduction, management, and use of computers in schools and the roles of computers in education in general. Six countries took part in this project including a team from Singapore. 相似文献
117.
Paul T. P. Wong 《Learning & behavior》1978,6(1):82-93
Three runway experiments tested a stage model of extinction which postulated an orderly succession of three qualitatively different stages: habit, trial and error, and resolution. The model predicted that Stage 1 should be characterized by perseveration of habitual routes (i.e., response persistence) and the absence of competing responses; Stage 2, by an increase in investigatory behavior (response variation and hole exploration) and biting behavior; Stage 3, by a decrease in the competing responses of Stage 2 and continued increase in goal avoidance and substitution behavior (e.g., sand-digging). These predictions were largely confirmed. Further, Experiments 1 and 2 showed that, as expected by the model, continuous reinforcement (CRF) resulted in more practice of habitual routes in acquisition and greater response persistence, while partial reinforcement (PRF) resulted in more route variation and hole exploration in acquisition and greater goal persistence which was attributable to prior reinforcement of a trial-and-error coping strategy. Results of Experiment 3, which combined training trials and reward magnitudes orthogonally, supported the prediction that response persistence was positively related to training trials, and goal persistence negatively related to reward magnitudes. All three experiments demonstrated an inverted-U function in investigatory and biting behavior, as predicted by the stage model. 相似文献
118.
Kenneth K. Poon Zijia Ng Meng Ee Wong Sarinajit Kaur 《Asia Pacific Journal of Education》2016,36(1):84-97
In this study, we sought to examine the perceptions of teachers and other school professionals towards the inclusion of secondary school students with special educational needs (SEN), and the associated factors. The Sentiments, Attitudes and Concerns about Inclusive Education Revised scale (SACIE-R) was completed by 131 teachers and school professionals from two mainstream secondary schools in Singapore. The findings revealed an overall neutral attitude towards inclusion. Together, confidence in teaching students with SEN, the level of training SEN support, as well as experience teaching students with SEN account for a large proportion of the variance in ratings of inclusive perceptions. Further analyses revealed that confidence in teaching or supporting students with SEN was found to be a significant predictor of inclusive perceptions. The findings suggest that schools seeking to engage in inclusive practices should focus on ways to develop the confidence of personnel to support students with SEN. Professional development and mentorship were suggested as possible avenues. 相似文献
119.
Kevin Downing Richard Ho Kristina Shin Lilian Vrijmoed Eva Wong 《Educational studies》2007,33(1):1-13
It is now largely accepted that social and cultural factors have a significant impact on cognitive development in children. Piaget acknowledged the impact of social factors and peer interaction on cognitive development. However, there has been relatively little work on the impact of social and cultural factors on the development of metacognition in first‐year university students. Using the Learning and study strategies inventory (LASSI) as a measure of metacognition, this study samples first‐year undergraduates in Hong Kong (N = 1815) and identifies significant differences in metacognitive abilities between students living in their home environment and those who have moved away from their family and, in some cases, culture, to pursue undergraduate education. 相似文献
120.
Wong Gary K. W. Li Yiu Keung Lai Xiaoyan 《Educational technology research and development : ETR & D》2021,69(5):2813-2843
Educational technology research and development - Online discussion forums are common features of learning management systems; they allow teachers to engage students in topical discussions in... 相似文献