脑挫裂伤后皮质神经元c-fos基因表达的意义     

薄爱华  张晓丽  张辉  张国辉  李卫东  常宝 《河北北方学院学报(医学版)》2003,20(3):1-2

目的 :探讨脑挫裂伤后大鼠脑皮质神经元c -fos基因表达的意义。方法 :采用Feeney’s自由落体致伤法 ,复制大鼠大脑皮质挫裂伤动物模型。伤后 1h、2h、4h、8h、12h、2 4h、4 8h和 72h杀死大鼠取脑组织 ,制作冰冻切片 ;SP免疫组织化学染色。结果 :病灶中心区阳性细胞很少 -而在挫裂伤灶周围区则阳性细胞密集。阳性细胞主要是锥体细胞和星形细胞。伤后 1～ 2hc -fos阳性细胞密度较高 ;伤后 4 8～ 72h阳性神经元减少或消失。结论 :脑外伤可以导致皮质神经元c-fos基因表达 ,而且有时间依赖性。  相似文献   

大鼠神经胶质瘤和嗜铬细胞瘤中P2X受体表达特征的研究     

茹琴  田香  陈琳  乐凯  马宝苗  李超英 《河北北方学院学报(医学版)》2012,(4):1-7

目的：采用实时荧光定量聚合酶链式反应（polymerase chain reaction,PCR）技术,研究P2X受体在大鼠神经胶质瘤和嗜铬细胞瘤及原代培养皮层神经元和星形胶质细胞上的表达差异。方法：取新生1-2 d SD大鼠大脑皮层,分离纯化神经元和星形胶质细胞,并采用实时荧光定量PCR技术,比较P2X受体在大鼠胶质瘤C6细胞、大鼠肾上腺嗜铬细胞瘤PC-12细胞、星形胶质细胞和皮层神经元上的表达差异。结果：C6细胞P2X2、P2X3和P2X5表达水平显著高于星形胶质细胞,P2X4、P2X6和P2X7表达水平显著低于星形胶质细胞,PC-12细胞P2X1、P2X2、P2X3和P2X6表达水平显著高于皮层神经元,P2X5和P2X7表达水平则显著低于皮层神经元。此外,还发现P2X2、P2X5和P2X6在C6和PC-12细胞上的表达水平存在显著差异。结论：大鼠胶质瘤和嗜铬细胞瘤细胞表达多种P2X受体,且与原代培养细胞存在表达差异,提示核苷酸介导的信号传递系统可能作为潜在的肿瘤治疗靶点。  相似文献   

Measuring perceived competence and social acceptance in children with cerebral palsy     

Vanessa Scholtes  Adri Vermeer  Geoffrey Meek 《欧洲特需教育杂志》2013,28(1):77-87

The Dutch Pictorial Scale of Perceived Competence and Social Acceptance for Children with Cerebral Palsy was translated and administered to an English sample. This scale was developed to assess the child's perception on cognitive, physical and social domains. Thirty-two children, aged 4 to 9 years, were tested twice. The results indicate good test/retest reliability and good internal consistency. The results on the intercorrelations between the four sub-scales supported internal validity of the pictorial scale. It is concluded that the pictorial scale for young children with cerebral palsy is a reliable and valid instrument for determining the perception of children with cerebral palsy, and application in clinical and class settings is discussed.  相似文献   

Study of clinical features of amyloid angiopathy hemorrhage and hypertensive intracerebral hemorrhage   总被引：3，自引：0，他引：3  

詹仁雅  童鹰  沈剑峰  LANG E.  PREUL C.  HEMPELMANN R.G.  HUGO H.H.  BUHL R.  BARTH H.  KLINGE H.  MEHDORN H.M 《Journal of Zhejiang University. Science. B》2004,(10)

Objective: The purpose of this study was to differentiate between cerebral amyloid angiopathy (CAA) and hypertension (HTN) based on hemorrhage pattern interpretation. Methods: From June 1994 to Oct., 2000, 83 patients admitted to our service with acute intracerebral hemorrhage (ICH) were investigated retrospectively; 41 patients with his-tologically proven diagnosis of cerebral amyloid angiography and 42 patients with clear history of hypertension were investigated. Results: Patients with a CAA-related ICH were significantly older than patients with a HTN-related ICH (74.0 years vs 66.5 years, P<0.05). There was a significantly higher number of hematomas>30 ml in CAA (85.3%) when compared with HTN (59.5%). No basal ganglional hemorrhage was seen in CAA, but in 40.5% in HTN. In CAA-related ICH, su-barachnoid hemorrhage (SAH) was seen in 26 patients (63.4%) compared to only 11 patients (26.2%) in HTN-related ICH. Intraventricular hemorrhage was seen in 24.4% in CAA, and in 26.2% in HTN. Typical features o  相似文献   

脑与创新素质   总被引：2，自引：0，他引：2  

燕良轼  谢家树 《湖南师范大学社会科学学报》2001,30(1):77-83

脑是创新素质的主要承担。脑的发育状况，脑细胞的数量及组织结构、脑的重量等，对人的智力、创造力有一定影响，但不能绝对化。网状结构激活系统对科学创造中的意识唤醒水平，对直觉和顿悟现象的产生具有重要意义。大脑皮层结构，特别是两半球的协同活动，对人的创新素质具有决定性意义。因此，要培养创新素质，就必须重视左右脑的开发，实施全脑教育。  相似文献   

唇读大脑机制的功能性核磁共振研究     

汪斯斯 《中国特殊教育》2010,(7)

聋人和普通人在唇读的过程中大脑的很多区域都会得到激活。本文主要回顾和分析了国外运用功能性核磁共振（fMRI）技术对唇读大脑机制所做的相关研究,结果发现,唇读激活了大脑的视觉中枢、运动中枢、听觉中枢和语言中枢。大脑两半球在唇读中所起的作用也不一样,主要取决于不同唇读任务的需要。  相似文献   

移情的神经机制     

王丹  张霄  许远理 《兰州教育学院学报》2010,26(4):50-53

本文主要从镜像神经元、脑岛和前扣带回皮层三个方面对移情的神经机制进行阐述。希望通过对移情含义的理解以及神经机制的阐述,为移情的研究提供一定的参考。  相似文献   

Neurochemical and Neurobehavioral Effects of Low Lead Exposure on the Developing Brain     

Anita R. Bijoor  S. Sudha  T. Venkatesh 《Indian journal of clinical biochemistry : IJCB》2012,27(2):147-151

Lead is found in small but appreciable quantities in air, soil drinking water and food. Exposure to such amounts of lead does not cause acute lead toxicity, but produces subtle effects, particularly in children. The CDC advocates “safe” or “acceptable” levels of blood lead up to 10 μg/dl, while OSHA declares blood lead levels up to 40 μg/dl as “safe” or “acceptable” in the occupationally exposed. The objective of the study was to see if blood levels considered “safe” can cause changes in the biogenic neurotransmitters in the developing brain which may cause neurobehavioral defects like hyperactivity and other cognitive disorders. Albino Wistar rats were divided into the control and lead-treated groups. The control group was given unleaded water, while the lead-treated group was fed with 50 ppm lead acetate in drinking water. On day 45 the animals were subjected to a passive avoidance test, their blood analysed for ZPP and lead. They were then sacrificed and the neurotransmitters—Norepinephrine (NE) and its metabolite—methoxyhydroxyphenylglycol (MHPG) estimated in the brain areas associated with learning and memory—the frontal cortex, hippocampus and the striatum by HPLC-ECD. Our results showed significant increases in blood lead, NE and MHPG, while ZPP increase was insignificant. The rats showed neurobehavioral abnormalities as assessed by the passive avoidance test. We concluded that low blood levels of lead cannot be considered “safe” or “acceptable” as it causes neurotransmitter alterations. Increased NE turnover is implicated in hyperactivity disorders such as ADHD and Tourette syndrome.  相似文献   

间歇性低氧训练对大鼠血清T、C和LH的影响     

王林  张云丽 《辽宁体育科技》2009,31(3):39-41

采用实验法观察间歇性低氧训练对大鼠血清睾酮（T）、皮质醇（C）、T／C比值和黄体生成素（LH）的影响,结果表明：间歇性低氧训练比游泳训练更能促使血清T、T／C比值和血清LH水平的提高,而使C下降更为明显,从而保持高睾酮低皮质醇水平;间歇性低氧训练比游泳训练对大鼠血清激素有更大的影响,暗示其更有利于提高大鼠的运动能力。  相似文献   

Concurrent pulmonary thrombosis with systemic embolism: a case report     

Xiao-jie Xie  Ju-bo Jiang  Jun Jiang  Jian-an Wang 《Journal of Zhejiang University. Science. B》2014,15(9):838-844

Based on different mechanisms of blood coagulation, coexistence of venous thromboembolism and arterial thrombosis in a single individual is extremely rare in clinical practice. Both antiplatelet and anticoagulation therapy should be adopted for patients with arteriovenous embolism. Balancing the risk of ischemia and hemorrhage is especially challenging in these patients in order to achieve an optimal clinical benefit. We report on a 55-year-old female with acute pulmonary embolism (PE), subsequently diagnosed as having acute myocardial infarction (AMI) and a cerebral infarction. Examinations had been carried out, excluding potential arteriovenous shunts, cancer, antiphospholipid syndrome and other common hypercoagulable states. A combination of an anticoagulant drug (rivaroxaban, an Xa inhibitor) and an antiplatelet agent (clopidogrel, an ADP receptor inhibitor) was prescribed with a β-blocker and atorvastatin. The embolus was gradually shrunk during the next 10 months, and then it turned back into expanding. During the 16 months’ follow-up, an aneurysm of left ventricular apex was found through an echocardiogram and an angiotensin-converting enzyme inhibitor was administered. We conclude that combined anticoagulation and antiplatelet therapy significantly relieved the symptoms and improved the prognosis in patients suffering from arteriovenous embolism without any major clinical bleeding events.  相似文献