排序方式： 共有23条查询结果，搜索用时 62 毫秒
11.
转化学业不良学生 ,既是实施素质教育的必然要求 ,也是落实教育平等原则的重要举措。经调查研究可知 :学业不良学生的形成有复合原因 ,而决定因素在于教师的教育、教学素质。为此 ,改革学校教育 ,提高教师素质 ,从而改善学业不良学生的非智力因素和认知结构 ,是行之有效的策略。 相似文献
12.
马丁 《珠海城市职业技术学院学报》2005,11(3):19-21
职业教育必定是以“职业教师”为中心的教育。如何转化和提高教师的教学职能，使其从“学术性”转化为“师范性”，从知识“广泛性”转化为技能“专才性”，特别是由传统教育模式转化为以操作技能为教育的职业技术学院尤为关键，而其中教师职业培训的途径是其发展的瓶颈。在多种有利于拓展此瓶颈的途径中，校企联合办实训基地最为可行。途径的顺畅性也将直接影响到真正意义上职业教育的发展速度。 相似文献
13.
A number of factors are linked with non-alcoholic fatty liver diseases (NAFLD), a condition that ranges from clinically benign
fatty liver to its more severe form, non alcoholic steatohepatitis (NASH). In this study, we evaluated the role of cytokines
secreted from adipose tissue in the pathogenesis and progression of NAFLD. We also compared anthropometric profile, lipid
profile and insulin resistance data in 105 NAFLD patients with 77 normal subjects. These subjects showed a normal serum albumin
level, prothrombin time and renal function but elevated aminotransferases. Predisposing factors were diabetes mellitus (35%),
overweight (56%) and hyperlipidemia (44%). Insulin resistance (IR), determined by homeostasis model assessment (HOMA) was
confirmed in 70% patients with NAFLD and 42% patients fulfilled the minimum criteria for insulin resistance syndrome (IRS).
NAFLD patients showed elevated levels of pro-inflammatory cytokines tumor necrosis factor (TNF)-α, and interleukin (IL)-6,
while anti-inflammatory cytokines IL-4 level decreased and IL-10 level remain unchanged; however, TGF-β1 level elevated significantly
compared to normal subjects. While insulin level and HOMA-IR both were significantly positively correlated with BMI, waist-to-hip
ratio, total cholesterol, VLDL-cholesterol, triglyceride and TGF-β1; glucose, IL-6 and TNF-α levels were significantly positively
correlated with HOMA-IR only. In conclusion, pro-inflammatory cytokines play an important link between metabolic and liver
disorders in the fat accumulation, and thereby cause IR, inflammation and liver fibrosis. 相似文献
14.
K. Sri Manjari Pratibha Nallari A. Vidyasagar A. Jyothy A. Venkateshwari 《Indian journal of clinical biochemistry : IJCB》2012,27(2):152-156
Chronic pancreatitis (CP) presenting clinically with upper abdominal pain, as well as exocrine and endocrine insufficiencies, is characterized by irreversible morphological and functional alterations in the pancreas. The objective of the present study is to investigate the plasma levels of transforming growth factor-β 1 (TGF-β1), matrix metalloproteinases MMP-1 (collagenase) and MMP-3 (stromelysin) in CP. A total of 71 CP patients and 100 control subjects were considered for the study. Plasma levels of TGF-β1, MMP-1 and MMP-3 were determined by enzyme-linked immunosorbent assay in patients and control subjects. The plasma levels of TGF-β1 and MMP-1 were significantly elevated in patients compared to control group (*P = 0.0301, **P < 0.0001). However, there was no significant difference in the plasma levels of MMP-3 between patients and controls (P = 0.3756). The elevated levels of TGF-β1 and MMP-1 may influence the inflammatory reactions by enhancing the pancreatic stellate cell activation and deposition of extracellular matrix resulting in pancreatic fibrosis. Thus, the present study highlights the role of fibrogenic cytokine marker TGF-β1 and matrix metalloproteinases in the pathogenesis of CP. 相似文献
15.
Shu-fan ZHAO Mao-zhou CHAI Min WU Yong-hong HE Tian MENG Bing SHI 《Journal of Zhejiang University. Science. B》2014,15(3):289-294
The purpose of this study was to investigate the effect of vitamin B12 on palatal development by co-administration of 2,3,7,8-tetrachlorodibenzo-p-dioxin (TCDD) and dexamethasone (DEX). We examined the morphological and histological features of the palatal shelf and expression levels of key signaling molecules (transforming growth factor-β3 (TGF-β3) and TGF-β type I receptor (activin receptor-like kinase 5, ALK5)) during palatogenesis among a control group (Group A), TCDD+DEX exposed group (Group B), and TCDD+DEX+vitamin B12 exposed group (Group C). While we failed to find that vitamin B12 decreased the incidence of cleft palate induced by TCDD+DEX treatment, the expression levels of key signaling molecules (TGF-β3 and ALK5) during palatogenesis were significantly modulated. In TCDD+DEX exposed and TCDD+DEX+vitamin B12 exposed groups, palatal shelves could not contact in the midline due to their small sizes. Our results suggest that vitamin B12 may inhibit the expression of some cleft palate inducers such as TGF-β3 and ALK5 in DEX+TCDD exposed mice, which may be beneficial against palatogenesis to some degree, even though we were unable to observe a protective role of vitamin B12 in morphological and histological alterations of palatal shelves induced by DEX and TCDD. 相似文献
16.
Guo-dong Xu Xin-bao Shi Le-bo Sun Qing-yun Zhou Da-wei Zheng Huo-shun Shi Yong-liang Che Zi-shan Wang Guo-feng Shao 《Journal of Zhejiang University. Science. B》2013,14(6):460-467
Background
Epithelial-mesenchymal transition (EMT) is believed to be the critical process in malignant tumor invasion and metastases, and has a great influence on improving the survival rate in non-small-cell lung cancer (NSCLC) patients. Recent studies suggested that eukaryotic initiation factor 5A-2 (eIF5A-2) might serve as an adverse prognostic marker of survival. We detected eIF5A-2 in NSCLC A549 cells, and found that the invasive capability correlates with the eIF5A-2 expression.Methods
Transforming growth factor (TGF)-β1 was used to induce EMT in A549 cells. Western blotting, immunofluorescence, wound healing assay, and transwell-matrigel invasion chambers were used to identify phenotype changes. Western blotting was also used to observe changes of the expression of eIF5A-2. We down-regulated the eIF5A-2 expression using an eIF5A-2 siRNA and identified the phenotype changes by western blotting and immunofluorescence. We tested the change of migration and invasion capabilities of A549 cells by the wound healing assay and transwell-matrigel invasion chambers.Results
After stimulating with TGF-β1, almost all A549 cells changed to the mesenchymal phenotype and acquired more migration and invasion capabilities. These cells also had higher eIF5A-2 protein expression. Down-regulation of eIF5A-2 expression with eIF5A-2 siRNA transfection could change the cells from mesenchymal to epithelial phenotype and decrease tumor cell migration and invasive capabilities significantly.Conclusions
The expression of eIF5A-2 was up-regulated following EMT phenotype changes in A549 cells, which correlated with enhanced tumor invasion and metastatic capabilities. Furthermore, in the A549 cell line, the process of EMT phenotype change could be reversed by eIF5A-2 siRNA, with a consequent weakening of both invasive and metastatic capabilities. 相似文献17.
王满福 《河北能源职业技术学院学报》2003,3(1):5-6,10
从国内电信市场的竞争，分析企业专用通信网进入市场参与竞争，服务水平不适应市场竞争形式的问题，阐述转变服务观念、创新服务内容的重要性，进一步分析了服务与公司发展的关系，提出了提高服务质量的几项具体措施。 相似文献
18.
职教英语教学与文化因素浅谈 总被引：1，自引：0，他引：1
程振义 《黄冈职业技术学院学报》2006,8(2):63-66
本文从文化角度对尚处于转型时期的职教英语教学进行考察,分析了目前教材、师资和教法存在的文化缺憾,着重指出提高其教学质量的关键在于,教师首先要提高对于文化因素的认识,增强文化意识和自身语言文化素养,转变观念,革新教学方法。 相似文献
19.
分析我国出版业转企改制前后“三秘’图书出版环境的变化,认为目前“三农”图书出版依然没有跳出对政府的路径依赖,并对该路径依赖下“三农”图书出版中存在的问题进行探讨。 相似文献
20.