Ecological principle meets cancer treatment: treating children with acute myeloid leukemia with low-dose chemotherapy     

Yixin Hu  Aili Chen  Xinchang Zheng  Jun Lu  Hailong He  Jin Yang  Ya Zhang  Pinpin Sui  Jingyi Yang  Fuhong He  Yi Wang  Peifang Xiao  Xin Liu  Yinmei Zhou  Deqing Pei  Cheng Cheng  Raul C Ribeiro  Shaoyan Hu  Qian-fei Wang 《国家科学评论(英文版)》2019,6(3):469

Standard chemotherapy regimens for remission induction of pediatric acute myeloid leukemia (AML) are associated with significant morbidity and mortality. We performed a cohort study to determine the impact of reducing the intensity of remission induction chemotherapy on the outcomes of selected children with AML treated with a low-dose induction regimen plus granulocyte colony stimulating factor (G-CSF) (low-dose chemotherapy (LDC)/G-CSF). Complete response (CR) after two induction courses was attained in 87.0% (40/46) of patients receiving LDC/G-CSF. Post-remission therapy was offered to all patients, and included standard consolidation and/or stem cell transplantation. During the study period, an additional 94 consecutive children with AML treated with standard chemotherapy (SDC) for induction (80/94 (85.1%) of the patients attained CR after induction II, P = 0.953) and post-remission. In this non-randomized study, there were no significant differences in 4-year event-free (67.4 vs. 70.7%; P = 0.99) and overall (70.3 vs. 74.6%, P = 0.69) survival in the LDC/G-CSF and SDC cohorts, respectively. After the first course of induction, recovery of white blood cell (WBC) and platelet counts were significantly faster in patients receiving LDC/G-CSF than in those receiving SDC (11.5 vs. 18.5 d for WBCs (P < 0.001); 15.5 vs. 22.0 d for platelets (P < 0.001)). To examine the quality of molecular response, targeted deep sequencing was performed. Of 137 mutations detected at diagnosis in 20 children who attained hematological CR after two courses of LDC/G-CSF (n = 9) or SDC (n = 11), all of the mutations were below the reference value (variant allelic frequency <2.5%) after two courses, irrespective of the treatment group. In conclusion, children with AML receiving LDC/G-CSF appear to have similar outcomes and mutation clearance levels, but significantly lower toxicity than those receiving SDC. Thus, LDC/G-CSF should be further evaluated as an effective alternative to remission induction in pediatric AML.  相似文献   

心肌肌钙蛋白与马拉松等耐力运动后右心室心肌损伤的综述研究     

张玉丽  王松涛 《中国体育科技》2020,(6):22-31

作为心肌损伤的特异性指标,心肌肌钙蛋白(cTn)在临床诊断心肌病中具有较高的价值。马拉松等耐力运动后,血清cTn异常升高的生理、病理意义仍存在较大争议。通过总结马拉松等耐力运动后cTn的释放规律和右心室(RV)损伤情况,研究探讨了运动后血清cTn的可能来源,以及利用血清cTn评价运动后RV心肌损伤性质的可行性。研究认为:1)一次性马拉松等耐力运动后的血清cTn异常升高,可能是由于RV心肌结构蛋白损伤所致;2)一次性马拉松等耐力运动,可能导致不同性质的RV心肌损伤,通过结合运动后血清cTn的升高水平和持续升高的时间,可以对RV心肌损伤的性质进行评价。  相似文献   

Review:Study progress in therapeutic effects of traditional Chinese medicine monomer in severe acute pancreautis     

ZHANG Xi-ping  LIU Da-ren  SHI Yan 《Journal of Zhejiang University. Science. B》2007,8(2)

Severe acute pancreatitis (SAP) is a common acute abdomen clinical problem characterized by high mortality, multiple complications, complicated pathogenesis and difficult treatment. Recent studies found traditional Chinese medicine (TCM)monomers have markedly good effect for treating SAP. Many TCM monomers can inhibit pancreatin, resist inflammation, improve microcirculation and immunoloregulation, etc. to block the pathological progress of SAP in multiple ways, reduce complications and lower mortality with rapid effects. It is significant for enhancing SAP treatment to deeply understand the current situation in TCM monomers for treating SAP and take precious references therein. This article summarizes the treating effects and mechanisms of TCM monomers for SAP in recent years.  相似文献   

触发脑梗死危险因素的Logistic回归分析     

史宝林  武艳华  张杰  孙海鹏  王少兰 《河北北方学院学报(医学版)》2006,23(4):25-27

目的：探讨与脑梗死急性发作有关的触发危险因素，为有效防治突发脑梗死提供依据。方法：采用病例对照研究方法对研究对象进行调查，应用非条件Logistic回归模型完成单因素及多因素分析。结果：多因素非条件Logistic逐步回归显示近期感染OR=7．52，TIA的OR=2．11，情绪波动OR=1．59和预防性治疗OR=0．15与脑梗死猝发有关联，其差别有统计学意义（P〈0.05）。结论：近期感染、TIA、情绪波动是触发脑梗死的独立危险因素，而预防性治疗则是保护因素之一。  相似文献   

碳纤维增强型树脂基复合材料的生物安全性评价   总被引：3，自引：0，他引：3  

刘丽  高燕  张烈焚 《科技通报》2005,21(6):693-696

目的评价碳纤维增强型树脂基复合材料(CFRP)的生物相容性,为其在口腔临床中的应用提供依据。方法本研究进行三种体内外试验,即短期全身毒性试验(经口途径),静脉注射急性全身毒性试验和溶血试验。结果实验一:对照组和试验组大鼠均未出现毒性反应,对照组和实验组的体重增长率和食物利用率无明显差异(P>0.05),肉眼观察动物重要脏器,均未出现病理变化;实验二:对照组和试验组小鼠均未出现毒性症状,试验组和对照组小鼠体重无明显差异(P>0.05);实验三:测的体外溶血率2%。结论碳纤维增强型树脂基复合材料对动物无全身毒性作用也无溶血作用。  相似文献   

LONG-TERM INHIBITION OF Na~ /H~ EXCHANGE ATTENUATES CARDIAC REMODELING AFTER MYOCARDIAL INFARCTION IN RATS     

XIA Qin-gui  *L  Oliver Chung  Heidi Spitznagel  Thomas Unger 《Journal of Zhejiang University. Science. B》2001,(4)

ＩＮＴＲＯＤＵＣＴＩＯＮＴｈｅＮａ /Ｈ ｅｘｃｈａｎｇｅｒ (ＮＨＥ)ｉｓａｐＨ ｒｅｇｕｌａｔｏｒｙｐｒｏｔｅｉｎｐｒｅｓｅｎｔｉｎｔｈｅｐｌａｓｍａｍｅｍ ｂｒａｎｃｅｏｆｃａｒｄｉｏｍｙｏｃｙｔｅｓａｎｄｏｔｈｅｒｃｅｌｌｔｙｐｅｓ.ＡｌｔｈｏｕｇｈｓｅｖｅｒａｌｉｓｏｆｏｒｍｓｏｆＮＨＥｈａｖｅｂｅｅｎｄｅ ｃｒｉｂｅｄ,ｔｈｅｐｒｅｄｏｍｉｎａｎｔｉｓｏｆｏｒｍｉｎｔｈｅｈｅａｒｔｉｓｔｈｅｕｂｉｑｕｉｔｏｕｓＮＨＥ 1 ,ｗｈｉｃｈｕｎｄｅｒｃｅｎｔａｉｎｐｈｙｓｉｏｌｏｇｉｃａｌｃｏｎｄｉｔｉ…  相似文献   

劝转与涅檠——从《狂人日记》与《凤凰涅榘》看鲁迅和郭沫若的救世思想     

王雨海 《信阳师范学院学报(哲学社会科学版)》2005,25(4):94-98

鲁迅与郭沫若通过狂人和凤凰形象的塑造对当时社会进行了深刻的解剖和批判，展示了早期先进知识分子的特点和作用，同时，他们提出了拯救社会的方式和方法：鲁迅主张通过劝转使人吃人的社会过渡到真正的人的社会；郭沫若则主张通过涅榘让旧世界毁灭，诞生一个崭新的世界。这两种方式体现了鲁迅与郭沫若不同的主体态度和人生选择，也显现了他们在救世思想上的分歧和不同。  相似文献   

血塞通加尼莫地平治疗血栓性梗塞的疗效观察     

戴铁军  刘界军  彭慕牛 《岳阳职业技术学院学报》2005,20(4):86-87

目的:观察血塞通加尼莫地平治疗血栓性脑梗塞的疗效。方法:52例血栓性脑梗塞患者随机分为血塞通组和丹参组血塞通组28例,在病因治疗和常规治疗基础上,加用血塞通注射液500mg静滴,每日一次(加5％G．S或0．9N．S)及口服尼莫地平20mg每日三次。丹参组24例,病因治疗及常规治疗其础上加丹参20ml静滴每日一次(加5％G．S或0．9％N．S)。观察入选病例4周后临床症状变化及头颅CT改变。结果:血塞通组总有效率79％,丹参纽总有效率49．7％。结论:血塞通加尼莫地平可明显改善血栓性脑梗塞的症状。  相似文献   

脂蛋白(a)与脑梗塞的关系     

阎智宏  梁庆智  张效云  董明纲  孙敏 《河北北方学院学报(医学版)》2001,18(2):41-42

目的研究脑梗塞患者血浆脂蛋白(a)水平.方法以酶联免疫吸附法(ELISA)测定44例脑梗塞患者与38名健康人血浆脂蛋白(a)浓度.结果脑梗塞患者的脂蛋白(a)浓度显著高于正常健康人.结论血浆高脂蛋白(a)水平是脑梗塞的重要危险因素.  相似文献   

藻酸双脂钠对急性脑梗死患者纤维蛋白原、脂蛋白(a)的影响及疗效观察     

潘妍婷  赵宏  雷霞 《河北北方学院学报(医学版)》2007,24(1):22-24

目的：探讨藻酸双脂钠（PSS）治疗急性脑梗死患者血液成分变化及疗效。方法：急性脑梗死患者158例，随机分为两组。对照组：78例，常规治疗；治疗组：80例，在常规治疗基础上，应用藻酸双脂钠注射液100mg加入0．9％氯化钠静脉滴注，每日一次，连续观察14d。对比分析二组治疗前后脂蛋白（a）、血脂、纤维蛋白原等血液流变学指标．并动态观察治疗前后临床神经功能缺损评分。结果：藻酸双脂钠可降低全血粘度、血浆粘度、血小板聚集率、纤维蛋白原及血清TC、TG、LDL，与治疗前比较有显著性改变（P〈0．01或P〈0．05）；与对照组比较有显著性差异（P〈0．01或P〈0．05）．但对脂蛋白（a）无影响；近期预后较常规治疗组好（P〈0．05）．结论：藻酸双脂钠可改善血液高粘滞状态，起到降低纤维蛋白原、抗血小板聚集作用，可改善近期临床神经功能缺损程度。  相似文献