CYP1A1多态性在上海人群中的分布     

邹晓菊岑晓江  卢大儒 《昆明师范高等专科学校学报》2004,26(4):53-58

由于单核苷酸多态性(SNPs)在寻找致病基因，了解遗传多样性、环境与基因的相互作用方面有重大价值，SNPs研究已越来越多地引起了学术界和产业界的兴趣．CYP1A1编码的酶在烟草的主要几类前致癌物(如PAHs和芳香胺类物质)的代谢活化中有重要作用，其多态性与个体对环境相关的癌症的易感性密切相关．本研究采用PCR-RFLP技术在上海人群中，对CYP1Al的两个SNPs：CYP1A1 m1和m2进行了基因分型．结合其它已发表的数据，我们的研究表明，在中国人群的不同群体中，m1等位基因的频率分布比较一致，而m2等位基因的频率分布则存在着显著的不同．  相似文献   

“It’s My Job Now,I Guess”: Biographical disruption and communication work in supporters of young adult cancer survivors     

《Communication monographs》2012,79(4):491-514

ABSTRACT

This study uses narrative interviews to describe how 25 young adult (YA) close supporters (i.e., romantic partners, siblings) experience an often invisible and uniquely burdensome biographical disruption following a young adult cancer survivor’s (YACS; i.e., 18–39) diagnosis. YA supporters reported varying levels of biographical interdependence with the YACS and family system uncertainty with other important supporters. These factors led YA romantic partners and siblings to engage in different types of communication work to negotiate and maintain primary and secondary support roles with parents and in-laws, to ensure that the YACS received helpful social support by gatekeeping (i.e., correcting, blocking) others’ support attempts, and to accommodate both their own and the YACS’s disrupted biographies.  相似文献   

抗肿瘤纳米中药制剂研究   总被引：1，自引：0，他引：1  

马千华 《鸡西大学学报》2012,(8):155-156

纳米中药作为中药的新剂型,具有缓释、靶向性等特点,能够降低中药的毒副作用,提高中药的治疗效果,同时对许多肿瘤的治疗显示了良好的抑制效应。拟对紫杉醇冻干纳米乳的制备及理化性质、羟基喜树碱纳米乳的制备及其抗癌作用做初步研究。  相似文献   

乳癌生活现状透视——《白虎郢都》主旨解读     

张蕴华 《郧阳师范高等专科学校学报》2012,32(1):50-54

徐春林写作《白虎郢都》就是要告诉我们郢都的白虎不是舒一晴不是黄晓妮,而是功利至上享乐至上欲望至上导致的价值观病变、道德沉沦、人性沦丧的社会隐痰.《白虎郢都》与《废都》与《拯救乳房》最大的不同是它不以单纯赤裸写“性”为卖点和以疗救生理的乳癌为出发点,而是以揭露当下现实社会的隐疾为立足点.有道德感和社会良知的年轻作家用心血酿造“郢都社会”,无情暴露社会的变态,目的就是拯救现实社会的道德和良知.掩藏和暴露在我们身理和心理的“隐痰”,终将根除.拯救乳房是拯救女性,更是拯救我们的母亲.  相似文献   

洛铂联合重组人血管内皮抑素胸腔内注射治疗肺癌恶性胸腔积液临床研究     

曹宇  赵光强  黄云超 《大理师专学报》2012,(12):41-43

目的：研究洛铂联合重组人血管内皮抑素（恩度）治疗肺癌恶性胸腔积液的有效性和安全性。方法：对确诊为肺癌恶性胸腔积液的63例患者进行分析,采用胸腔内注射治疗方法,其中32例注入洛铂和恩度（A组）,31例注入顺铂和恩度（B组）,比较两组间疗效、生活质量和毒副作用。结果：洛铂和恩度组与顺铂和恩度组在疗效和生活质量改善上比较差异无统计学意义（P〉0．05）,在毒副作用方面,洛铂和恩度组白细胞（WBC）减少、贫血、恶心呕吐发生率较顺铂和恩度组低,差异有统计学意义（P〈0．05）。结论：洛铂联合恩度胸腔内注射治疗肺癌恶性胸腔积液疗效与顺铂联合恩度相当,毒副作用较轻。  相似文献   

Methylenetetrahydrofolate reductase C677T polymorphism predicts response and time to progression to gemcitabine-based chemotherapy for advanced non-small cell lung cancer in a Chinese Han population     

Wei HONG  Kai WANG  Yi-ping ZHANG  Jun-yan KOU  Dan HONG  Dan SU  Wei-min MAO  Xin-min YU  Fa-jun XIE  Xiao-jian WANG 《Journal of Zhejiang University. Science. B》2013,14(3):207-215

Objective:The aim of this study was to evaluate the association between the methylenetetrahydrofolate reductase(MTHFR) C677T excision repair cross-complementation group 1(ERCC1) genetic polymorphisms and the clinical efficacy of gemcitabine-based chemotherapy in advanced non-small cell lung cancer(NSCLC).Methods:A total of 135 chemonaive patients with unresectable advanced NSCLC were treated with gemcitabine/platinum regimens.The polymorphisms of MTHFR C677T,ERCC1 C8092A,and ERCC1 C118T were genotyped using the TaqMan methods.Results:The overall response rate was 28.9%.Patients with MTHFR CC genotype had a higher rate of objective response than patients with variant genotype(TT or CT)(41.2% versus 19.1%,P=0.01).Median time to progression(TTP) of patients with MTHFR CC genotype was longer than that of patients with variant genotype(7.6 months versus 5.0 months,P=0.003).No significant associations were obtained between ERCC1 C118T and C8092A polymorphisms and both response and survival.Conclusions:Our data suggest the value of MTHFR C677T polymorphism as a possible predictive marker of response and TTP in advanced NSCLC patients treated with gemcitabine/platinum.  相似文献   

POLITICS OF LOCAL INTERLIBRARY COOPERATION     

《Public Library Quarterly》2013,32(3-4):29-34

Social and political issues are key factors in developing cooperation among public libraries. Experiences in public library cooperation have shown that the acceptance of cooperation as an ideal, patron reaction and acceptance, local pride and control, and the education and cooperation of the library board, local government officials, and funding agencies are all important in providing the best possible framework for cooperation. The commitment to and understanding of the implications, changes, and modifications that cooperation requires are also important. Realization that interpretation of what cooperation means and that unequal contributions can be expected are necessary steps in developing effective arrangements among public libraries.  相似文献   

ACT UP 25: HIV/AIDS,Archival Queers,and Mnemonic World Making     

Charles E. Morris III 《Quarterly Journal of Speech》2013,99(1):49-53

Audre Lorde's speech, “The Transformation of Silence into Language and Action, “sheds light on the margins of rhetoric in the sense of the public speech because she examines factors that may cause some people to remain silent while enabling others to speak and act. “Margins” refers both to the parameters employed for defining a practice and the relative place or value of varied activities exemplifying the practice. Lorde interweaves her commentary on the silence surrounding breast cancer with insights about silence drawn from her experiences as a member of several subordinated communities, especially as they relate to the misuse of power to silence those who are different. Her speech comments on silencing and power, sexism, verbal abuse, violence and sexualized aggression, shame, the taboo, and hostile social environments. Paradoxically, Lorde's speech is as much about the possibilities of rhetoric as its limits.  相似文献   

纳米氧化锌对人肺腺癌细胞A549的毒性   总被引：3，自引：0，他引：3  

王琳  王莉娟  张芳  丁文军 《中国科学院研究生院学报》2009,26(1):83-90

探讨纳米氧化锌（ZnO）对体外培养的人肺腺癌细胞A549的生物学效应。使用原子力显微镜（AFM）、透射电镜（TEM）和X射线衍射仪（XRD）研究纳米ZnO颗粒物的理化性质。然后,使用0mmol/L、0.1mmol/L、0.5mmol/L、1mmol/L、5mmol/L、10mmol/L的纳米ZnO处理体外培养的人肺腺癌A549细胞,MTT 法测定细胞生长活性。并且测定1mmol/L 纳米ZnO染毒24h后细胞培养液上清中,乳酸脱氢酶（LDH）和胞内的超氧化物歧化酶（SOD）、过氧化氢酶（CAT）的活性以及丙二醛（MDA）的含量。使用透射电镜和流式细胞仪检测细胞凋亡的情况。荧光染色检测细胞产生活性氧（ROS）的生成。实验所用的ZnO纳米颗粒为长75 nm、直径20nm的针状纤锌矿晶体。细胞实验结果表明,纳米ZnO颗粒对A549细胞的生长活性具有明显的抑制作用,存在剂量－效应关系。培养液上清中LDH活性显著升高（P < 0.05）,胞内CAT活性显著下降、MDA含量显著升高（P < 0.01）,但SOD活性下降不明显。荧光染色检测发现染毒后A549细胞出现细胞凋亡,而且细胞内ROS的生成与纳米ZnO存在剂量－效应关系。结论是纳米氧化锌诱导人肺腺癌A549细胞产生活性氧,引发细胞凋亡,并产生细胞毒性。  相似文献   

Blood glutathione levels in head and neck malignancies     

Y. P. Singh  O. P. Sachdeva  S. K. Aggarwal  K. Chugh  Harbans Lal 《Indian journal of clinical biochemistry : IJCB》2008,23(3):290-292

Blood glutathione was estimated in fifty patients of head and neck cancer in the age group of 18–76 years and the results were compared with a group of normal healthy controls. Mean blood glutathione level was found to be significantly lowered in patients than the controls. Irrespective of the site, TNM classification, histopathology, and character of lesion, fall in blood glutathione was nearly same in all the patients. The mean level was significantly increased after radiotherapy when compared with the levels before radiotherapy. The decreased levels of GSH in-patients with head and neck cancer, observed in the present study, may be due to its increased utilization by the cells. The results suggest that patients with head and neck cancer have increased oxidative stress.  相似文献