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11.
Two common fish species, mosquitofish (Gambusia affinis) and topmouth gudgeon (Pseudorasobora para) were exposed to different concentrations of fenitrothion in static system for 96 h. Hepatic glutathione S-transferase activity
was evaluated after 48 and 96 h pesticide exposure, and was also examined in fish pretreated with pepironyl butoxide and triphenyl
phosphate and then exposed to fenitrothion. Results indicated presence of intense glutathione S-transferase activity in both
species, mosquitofish exhibiting the higher activity. In both species the activity decreased as the concentration of fenitrothion
increased, topmouth gudgeon being more susceptible than mosquitofish. In mosquitofish pretreated with pepironyl butoxide,
glutathione S-transferase activity was increased (11.8%) compared with the control but in topmouth gudgeon it was decreased
(21.6%) at the end of 96 h. Glutathione S-transferase activity was significantly reduced in both species pretreated with triphenyl
phosphate at the end of 96 h exposure, topmouth gudgeon being highly susceptible.
Ph. D. student, from Southern Ethiopia Health Bureau, Center for Health Research, P. O. Box 317, Awassa, F. R. Ethiopia. 相似文献
12.
轻度间隔性有氧运动的抗氧化及抗衰老作用研究 总被引：3，自引：0，他引：3
史亚丽 《北京体育大学学报》1999,(4)
研究轻度间隔性有氧运动对衰老小鼠心肌、肝脏的氧化及衰老的影响,表明此种强度运动可明显降低衰老小鼠心肌MDA,提高抗氧化能力,降低脂褐素含量,延缓心肌衰老,而对肝脏则影响不大 相似文献
13.
谷胱甘肽是机体中重要的抗氧化物质,在细胞增殖中起着重要的作用,本文综述近年来运动与谷胱甘肽之间的关系的研究,包括谷胱甘肽的代谢、运动对谷胱甘肽影响及运动训练对谷胱甘肽影响的可能机制。 相似文献
14.
R. Premanand K. V. S. Naidu K. Soorya Kumari K. K. Reddy 《Indian journal of clinical biochemistry : IJCB》1994,9(1):50-53
The concentration of serum lipid peroxides, tocopherol and glutathione peroxidase (GPx) activity was measured in 75 patients
(43 males and 32 females) of different respiratory diseases aged 15–40 years. The results were compared with the values obtained
from 100 healthy persons of comparabie age. The patients of respiratory diseases showed elevated levels of lipid peroxides
with concomitant reduction of tocopherol and glutathione peroxidase activity. When these patients were categorised into different
groups depending on the type of the disease like pulmonary tuberculosis (PT), chronic obstructive pulmonary disease (COPD),
pulmonary tuberculosis and chronic obstructive pulmonary disease (PT and COPD) and suppurative lung disease (SLD). There was
no significant difference between the groups. A significant inverse relation was found between lipid peroxides versus tocopherol
and glutathione peroxidase activity in patients of respiratory diseases. The results suggest the involvement of lipid peroxidation
process in pulmonary damage. 相似文献
15.
抗坏血酸和谷胱甘肽在小麦幼苗冷激诱导抗冷性中的变化 总被引：2，自引：0，他引：2
以小麦幼苗为实验材料，研究冷激及冷胁追处理过程中的抗坏血酸和谷胱甘肽含量变化，结果显示冷激处理小麦幼苗可导致还原型抗坏血酸和还原型谷胱甘肽的含量比对照组高，而脱氢抗坏血酸和氧化型谷胱甘肽的含量比对照组低．表明冷激处理可以使小麦幼苗细胞内抗坏血酸库和谷胱甘肽库中还原状态的抗坏血酸和谷胱甘肽含量明显增加，以有效地清除低温胁追产生的活性氧的危害，从而提高小麦幼苗的抗冷性．说明抗坏血酸和谷胱甘肽参与冷激诱导抗冷性的过程中起重要作用。 相似文献
16.
《European Journal of Sport Science》2013,13(6):377-384
Abstract The aim of this study was to monitor biological markers of inflammation and oxidative stress, mood states, and recovery-stress states throughout an entire season in male handball players. Fourteen handball players (age 20.1±2.5 years) with a regular training and competitive background in handball (11.0±3.7 years) from the same club volunteered to participate. All participants completed 40 weeks of training. The training load was increased progressively throughout the season. Blood samples were collected and questionnaires were administered during preparatory, competitive, and recovery periods. Blood C-reactive protein and oxidized glutathione (GSSG) concentrations increased during periods of high load, while the reduced/oxidized glutathione ratio (GSH/GSSG) decreased. These changes were accompanied by a significant increase in total leukocyte count. Positive correlations were found between C-reactive protein, GSSG, GSH/GSSG ratio, and training load. No changes were observed in the Total Mood Disturbance score of the Profile of Mood States (POMS). However, scores on some Recovery-Stress Questionnaire for Athletes subscales, such as Injury, Physical Recovery, and Being in Shape, correlated with training load. Findings indicate that during periods of high training load, handball players developed a low grade of inflammation and oxidative state. Results support the usefulness of monitoring psychological and biological markers of inflammation, oxidative stress, and training load during season. 相似文献
17.
Athanasios Kabasakalis George Tsalis Ekaterini Zafrana Demetrios Loupos Vassilis Mougios 《Journal of sports sciences》2013,31(8):747-756
AbstractThroughout adolescence, swimmers begin to carry out demanding endurance and high-intensity training sets, the effect of which on redox status is largely unknown. The aim of the present study was to investigate the effects of 2000-m continuous swimming and 6 × 50-m maximal swimming on the redox status of adolescent swimmers. Fifteen male and 15 female swimmers, aged 14–18 years, provided blood samples before, immediately after, 1 h after, and 24 h after each exercise for the determination of redox status parameters. Oxidative damage was short-lived and manifest as increases in 8-hydroxy-2?-deoxyguanosine (8-OHdG) 1 h after high-intensity exercise (39%, P < 0.001) and in malondialdehyde immediately after both exercises (65%, P < 0.001). Alterations in antioxidant parameters were sustained during recovery: reduced glutathione decreased 24 h post-exercise (11%, P = 0.001), uric acid increased gradually after high-intensity exercise (29%, P < 0.001) and bilirubin peaked 24 h post-exercise (29%, P < 0.001). Males had higher 8-OHdG (49%, P = 0.001) and uric acid (29%, P < 0.001) concentrations than females. However, females showed higher values of malondialdehyde than males immediately post-exercise (30%, P = 0.039), despite lower pre-exercise values. In conclusion, both endurance and high-intensity exercise perturbed the redox balance without inducing prolonged oxidative damage in trained adolescent male and female swimmers. These swimming training trials were not found to be detrimental to the redox homeostasis of adolescents. 相似文献
18.
目的：探讨甲醛染毒对运动大鼠骨骼肌的毒性及刺五加的保护作用。方法：采用40只2月龄雄性WiStar大鼠,体重（180士10）g,随机分为对照组、模型组、刺五加组进行动式染毒,甲醛剂量分别为0．8mg／m3,2．4mg／m3。每天染毒30min,每周6次,连续4周,刺五加的灌胃剂量为104．17mg／kg,测定运动大鼠骨骼肌组织中的超氧化物歧化酶（SOD）、谷胱甘肽过氧化物酶（GsH-Px）、过氧化氢酶（CAT）的活性和丙二醛（MDA）的含量。结果：模型组与对照组相比,模型组大鼠骨骼肌组织中CAT、GSH-PX、SOD活性均明显低于对照组（P〈O．05）,MDA含量明显高于对照组（P〈O．05）。刺五加组与模型组相比,刺五加组大鼠骨骼肌组织中CAT、GSH-PX、SOD活性明显高于模型组（P〈O．05）,MDA含量显著低于模型组（P〈O．01）。结论：甲醛可以造成运动大鼠骨骼肌组织的氧化性损伤,而灌服刺五加可以有效缓解其毒性。 相似文献
19.
J. O. Olanlokun 《Indian journal of clinical biochemistry : IJCB》2008,23(1):62-66
The effect of oral administration of vitamin E for twenty-eight consecutive days on blood glucose, reduced glutathione levels,
antioxidant enzymes (superoxide dismutase and catalase activities), and levels of malondialdehyde (as an index of free radical-mediated
lipid peroxidation) was observed in the whole blood and liver of normal and alloxan-induced diabetic rats. It was found that
oral administration of vitamin E significantly (p<0.05) lowered the blood glucose level and increased the body weight of the
diabetic rats. The activities of superoxide dismutase and levels of reduced glutathione increased significantly (p<0.05) while
the level of lipid peroxidation decreased. 相似文献
20.
摘要：目的：探讨八周耐力训练对骨骼肌谷胱甘肽抗氧化系统的影响,以及Nrf2基因缺失的作用。方法：C57BL/6J野生型小鼠、Nrf2基因敲除小鼠各20只,随机分为安静对照组和耐力训练组,每组10只。耐力训练组采取坡度为0°,速度为12 m/min的跑台训练,1 h/d,5 d/周,共8周。完成训练48 h后取小鼠腿部骨骼肌,Western blot测定骨骼肌Nrf2、GSH-Px、GR、GCLc和GCLm蛋白表达,酶还原法测定骨骼肌GSH、GSSG含量。结果：1）Nrf2敲除鼠与野生鼠相比,骨骼肌内GSH-Px（P＜0.05）、GR（P＜0.05）、GCLc（P＜0.01）蛋白表达,GSH（P＜0.01）、GSSG（P＜0.05）含量和GSH/GSSG比值（P＜0.05）非常显著性或显著性下降,而GCLm蛋白表达无明显差异。2）耐力训练组与安静对照组相比,野生训练鼠骨骼肌Nrf2、GSH-Px、GCLc、GCLm以及GSH/GSSG比值均呈上升趋势,GSSG含量减少;Nrf2敲除训练鼠的谷胱甘肽相关酶蛋白表达以及GSH/GSSG比值则表现下降趋势,GSSG含量上升,但并无显著性。结论：Nrf2的缺失导致耐力训练不但没有提高机体抗氧化能力,反而加剧机体抗氧化水平的下降。 相似文献