Antioxidant and lipid lowering activities of Indian black tea     

Ramesh Chander  A. K. Khanna  Kanwal Raj  A. K. Rastogi 《Indian journal of clinical biochemistry : IJCB》2005,20(1):153-159

Indian black tea; CTC leaf and dust, produced by Tata Tea Limited, Kolkata, (India) was studiedin vitro as potential scavenger of oxygen free radicals. Super oxide anions were generated in a system containing xanthine—xanthine oxidase (enzymic system) and by NADH- phenozine methosulphate (non enzymic system). Anions were assayed in terms of uric acid formation and reduction of nitroblue tetrazolium salt, which were shown to be suppressed by tea extracts. Extracts from both leaf and dust also inhibted the formation of hydroxyl radicalsin vitro in the enzymic system comprising hypoxanthine—Cu⁺²—sodium ascorbate and xanthine oxidase and in non enzymic system of deoxyribose—Cu⁺²—sodium ascorbate and H₂O₂ as well as the Cu⁺² induced lipid peroxidation in human low density lipoprotein. Feeding with black tea in normal rats for sixty days increased their antioxidant activity and their liver microsomes were shown to be protected against peroxidation of lipids as stimulated by metal ions with enzymic or non enzymic reactants. Furthermore feeding with tea extracts in normal as well as triton WR—1339 induced hyperlipidemic rats caused decrease in their plasma levels of total cholesterol, phospholipids and triglycerides. The antioxidant and lipid lowering activities of both extracts from CTC leaf and dust tea was comparable and may be due to the presence of natural products like catechin and others.  相似文献   

Potent antiulcerogenic activity of ethanol extract of leaf ofPiper betle Linn by antioxidative mechanism     

Biswajit Majumdar  Susri Ray Chaudhuri  Arun Ray  Sandip K Bandyopadhyay 《Indian journal of clinical biochemistry : IJCB》2002,17(1):49-57

Pretreatment of an ethanolic extract of leaf ofPiper betle linn at a dose of 200mg/kg body weight, orally administered to rats for ten consecutive days, was found to possess a significant protective action against gastric lesions induced by indomethacin. The extract pretreatment resulted in significant increase in superoxide dismutase (SOD) and catalase (CAT) activity, increase in mucus, hexosamine and total thiol group content, but marked reduction in oxidatively damaged protein and peroxidised lipid levels as compared to untreated ulcerated control. The extract was also found to possess both superoxide and hydroxyl free radical scavenging action. The present observations establish the efficacy of the extract in prevention of experimentally induced peptic ulcer by indomethacin and antioxidant property appears to be predominantly responsible for such cytoprotective activity in the experimental model.  相似文献   

An audit of total and free thyroxine measurements in screening for hypo and hyperthyroidism in patients using chemiluminescence immunoassay     

J. J. Fleming  S. Rajaratnam  M. S. Seshadri  A. S. Kanagasabapathy 《Indian journal of clinical biochemistry : IJCB》2001,16(1):95-100

An audit of 2509 patient specimens analyzed for both total thyroxine (TT4) and free thyroxine (FT4) by the ACS-180 automated chemiluminescence immunoassay analyzer revealed that there were 219 discrepancies (8.7% of the total). A discrepancy was defined as one analyte within its reference range and the other outside. The discrepant results were divided into 4 groups: group A: normal TT4, but decreased FT4, 101 patients (4.0%); group B: increased TT4, normal FT4, 78 patients (3.1%); group C: decreased TT4, normal FT4, 34 patients (1.4%); and group D: normal TT4, increased FT4, 6 patients (0.2%). TSH measurements were available, by a 3^rd generation chemiluminescent assay, in 142 of these patients, and were consistent with the FT4 result in 72 patients, with TT4 in 61 cases and with neither in 9 patients. The clinical diagnosis was investigated in a subgroup of 43 endocrine patients. Thirteen of the 20 endocrine patients in group A were diagnosed as hypothyroid, with a measured serum TSH, in 11 of them, of median 14.6, range 1.2 to 46.2 μlU/ml. Eleven of the 19 endocrine patients in group B were on thyroid replacement, with a measured serum TSH, in 7 of them of <0.01 μlU/ml. The audit of current laboratory practice led to a suggestion to replace the current thyroid function screening strategy of measuring both TT4 and FT4 by the combination of FT4 and TSH. The reasons for the discrepancies and the alternative strategies for screening of thyroid function are discussed.  相似文献   

Effect of methyl mercury induced free radical stress on nucleic acids and protein: Implications on cognitive and motor functions     

Farhana Zahir  Shameem J Rizvi  Soghra K Haq  Rizwan H Khan 《Indian journal of clinical biochemistry : IJCB》2006,21(2):149-152

Mercury pollution and acute neurotoxicity of mercury is well known. The recent reports suggest the adverse effect of low dose mercury, though the available literature is still silent on its mechanism. This study was therefore undertaken to probe the effect of low dose methyl mercury induced heavy metal toxicity on free radical stress and its impact on behaviour of male albino rats. Male albino rats were exposed to 1 mg/kg body wt of methylmercury chloride for seven days, on day 8 they were tested for motor and memory functions. They were sacrificed later for biochemical estimations for rate of lipid peroxidation, nucleic acids, proteins in cerebrum, cerebellum and brain stem. There was an increase in the rate of lipid peroxidation showing methyl mercury induced free radical stress. The motor and memory functions demonstrated a clear decline, besides there was a lowering in the levels of nucleic acids and proteins as compared to controls. The results are important in view of recent reports that methyl mercury induced free radical stress results in early ageing and may serve as an initiating factor more specifically for neurodegenerative disorders like Alzeihemer's disease and dementias. The current findings support the notion that incorporating dietary antioxidants like curcumin, ascorbic acid and α-tocopherol in routine diet from early age may help combat the risk of developing such disorders in ensuing years.  相似文献   

Killing off the Competition     

Anthony Keating 《Media History》2016,22(1):85-100

In August 1929, James W. Upton, Editor of the republican newspaper, Honesty, discovered that that Seán Lemass and Gerald Boland, the Secretaries of the Fianna Fáil party, had issued a circular to their members that blackballed Honesty and promoted the sales of The Nation, a publication that Fianna Fáil's leader, Éamon de Valera, had recently brought under his control. The event that triggered this action was Upton's decision to publish an article critical of the Fianna Fáil leadership, something Upton did in the interest of freedom of speech. Upton, who was sympathetic to the Fianna Fáil cause, dubbed Lemass and Boland, ‘the Dublin Junta’ and accused them of launching an underhand attack to further their own careers and party ambitions. Fianna Fáil retaliated in the pages of The Nation, declaring that Honesty was no longer a republican journal and thereby destroying Honesty's readership. An exploration of these events reveals political duplicity and a fundamental misfit between the views of a republican idealist and hardheaded professional politicians. Upton believed that republicanism without journalistic freedom was no republicanism at all, whilst Lemass and Boland focused on building a disciplined party machine intent on suppressing dissent, within and without of its ranks.  相似文献   

秀出行伍一枝笔为将风骨称其文——读贺茂之散文集《感激》     

种衍璋 《广播电视大学学报》2007,(2):123-125

军旅作家贺茂之在《感激》中用生命的体验、燃烧的激情和灵动的彩笔记述了他三十七年军旅途中体味新颖、感情深刻、蕴含诗意和哲理的亲历、亲为和亲思。五十篇文章,皆系真人真事,真情真话,朴实自然、亲切感人。能“给人以德的浸润,才的引领、智的启迪、美的享受和力的激励”。  相似文献   

在环的乘法半群的同构下根的不变性     

裴银淑  王舒惠 《鞍山师范学院学报》2004,6(6):8-9

论证了在环的乘法半群的同构下,环的Bear根与Levitzki根保持不变.  相似文献   

世界区域经济合作发展与我国的战略抉择     

李炜 《平原大学学报》2007,24(3):5-8

区域经济一体化是当今国际经济合作的一个趋势,我国作为发展中大国和世界贸易大国应把握好这一机遇,积极参与并合理规划,为我国经济发展赢得良好和稳定的外部空间。从世界区域经济合作的发展历程、发展动因分析,进而归纳我国在这方面正确的应对策略。  相似文献   

台湾《自由中国》杂志研究     

刘业伟 《徐州师范大学学报(哲学社会科学版)》2006,32(2):45-51

《自由中国》杂志在台湾扮演了一个传播民主思想的重要角色,与上世纪20年代的其他政论刊物,在推进中国民主政治的过程中,构成了一代中国自由主义知识分子的价值谱系,在50年代为台湾社会实现政治转型提供了强大的精神资源。考察《自由中国》杂志的创刊与台湾当局的历次交锋等著名历史事件,有助于我们进一步认识台湾的民主政治进程。  相似文献   

Evaluation of antioxidant properties of berries     

P. Rani  K. Meena Unni  J. Karthikeyan 《Indian journal of clinical biochemistry : IJCB》2004,19(2):103-110

The present paper focuses on assessing the levels of various enzymatic and non-enzymatic antioxidants in selected berries of Indian sub-continent viz., gooseberry, grapes, orange and tomato. This study has revealed that orange, tomato and grapes possess predominant quantities of enzymatic antioxidants namely SOD, catalase and glutathione peroxidase respectively. The levels of antioxidants analyzed namely reduced glutathione, vitamin C and vitamin A were maximal in grapes, orange and tomato respectively. All the extracts of berries included in the present study inhibited iron inducedin vitro lipid peroxidation in erythrocytes, the extend of inhibition being highest for gooseberry and orange compared to tomato and grapes which could be attributed to their in-built antioxidant system.  相似文献