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21.
Finn Egil Tønnessen Torleiv Høien Ingvar Lundberg Jan Petter Larsen 《Reading and writing》1994,6(2):151-160
The Geschwind-Behan-Galaburda hypothesis of cerebral lateralization postulates an association between immune disorders and learning disabilities. So far, the empirical evidence for such a relationship has been ambiguous. The present study is an attempt to investigate the hypothesis in a population where all the individuals were affected by immune disorders. Thus, 29 students in a special school for asthmatic children (total number of students in the school: 32) were investigated. A number of reading tests with special focus on word decoding were administered. The parents filled in a detailed questionnaire on the prevalence of reading difficulties and immune disorders among the other family members. The proportion of students with reading problems — especially phonological problems — was much higher than would be expected in a normal population. Among the family members we also found an elevated incidence of both reading problems and immune disorders. A cautious interpreptation of these findings leads to tentative and partial support of the Geschwind-Behan-Galaburda hypothesis. 相似文献
22.
Lyu Sunjian Yuan Xuemei Liu Li Zhang Haiqi Yu Zhe Hang Xiaoying Shi Weida Wu Yinglei 《Journal of Zhejiang University. Science. B》2021,22(4):295-304
Trionyx sinensis Hemorrhagic Syndrome Virus(TSHSV) is an arterivirus newly discovered in Chinese softshell turtles. Little is known about the effect of antibodies against the virus or the distribution of the virus in different organs of infected turtles. In this study, a partial protein of TSHSV-HP4 was produced using a prokaryotic expression system, and its polyclonal antibody was generated. The polyclonal antibody was confirmed by western blot and dot enzyme-linked immunosorbent assay(dot-ELISA). The distribution of TSHSV in different organs of T. sinensis was examined by immunohistochemistry(IHC) and the expression of immune-related genes was analyzed using quantitative real-time polymerase chain reaction(qRT-PCR). The results indicated that the recombinant TSHSV-HP4 protein was successfully expressed, and the generated polyclonal antibody showed specific binding to viral particles in the lung tissues of infected turtles. The IHC assay indicated that the virus was highly localized in various cells, including intestinal lymphocytes,enterocytes, kidney epithelial cells, spleen cells, lung macrophages, and cardiomyocytes. The qRT-PCR analysis revealed that TSHSV was detected in all organs tested, including the lungs, liver, kidneys, spleen, and heart. The numbers of viral mRNA copies in lung and heart tissues were significantly higher in the virus-antibody group than in the virus group. The interferonstimulated genes(ISGs), myxovirus resistance protein 2(MX2) and radical S-adenosyl methionine domain containing 2(RSAD2) were highly upregulated in all groups of infected turtles. Antibody-dependent enhancement(ADE) seemed to occur after stimulation by the polyclonal antibody, because significantly greater expression of the two genes was detected in the virus-antibody group than in the virus group. Overall, these results are important in understanding the cell localization of TSHSV and the immune response of infected turtles. 相似文献
23.
几丁质对肿瘤及免疫作用的实验研究 总被引：4，自引：0，他引：4
采用微晶几丁质，观察其对小鼠肿瘤的抑制作用及对免疫功能和细胞毒性的影响。结果显示：经灌胃途径给予剂量为４００ｍｇ／ｋｇ的几丁质制剂，具有延缓小鼠腹水瘤生和作用；对小鼠实体瘤Ｓ１８０生长具有抑制作用，其抑瘤率达３３％。研究还表明，几丁质对小鼠腹腔巨噬细胞的吞噬功能具有明显的促进作用；对人二倍体２ＢＳ细胞和小鼠骨髓瘤ＳＰ２／０细胞地直接 相似文献
24.
观察鸡传染性贫血病弱毒苗多次免疫对肝线粒体中抗氧化酶活性的影响。方法：20只SPF鸡随机分为2组,每组10只,免疫组鸡用鸡传染性贫血弱毒苗免疫四次,每次间隔2W,对照组鸡用同剂量的生理盐水。最后一次免疫后10d取肝脏制备线粒体,利用测试盒测定肝线粒体中的GSH-PX活性、SOD活性和MDA含量。结果：对照组肝线粒体中GSH-Px活性、SOD活性和MDA含量分别为20．444±2．64U／mgprot、15．59±1．33U／mgprot和7．32＋1．89nmol／mL,免疫组肝线粒体中GSH-Px活性、SOD活性和MDA含量分别为24．85±3．53U／mgprot、24．284±4．17U／mgprot和5．264±1．24nmol／mL。与对照组相比,免疫组肝线粒体中GSH-PX活性显著提高（P〈0．05）,SOD活性极显著提高（P〈0．01）,MDA含量显著减低（P〈0．05）。结论：鸡传染性贫血病多次免疫可提高机体抗氧化能力。 相似文献
25.
低聚壳聚糖对肉仔鸡生长性能及免疫器官发育的影响 总被引：1，自引：0，他引：1
480羽1日龄AA肉鸡,随机分为4组,每组120羽,设6个重复,其中空白对照组饲喂玉米-豆粕型基础日粮,抗生素组基础日粮添加50mg/kg金霉素,试验Ⅰ组(低聚壳聚糖剂量组)和试验Ⅱ组(黄芪多糖高剂量组)分别添加20mg/kg和40mg/kg低聚壳聚糖,试验期42d,研究低聚壳聚糖对肉仔鸡生长性能及免疫器官发育的影响。结果显示,试验Ⅰ、Ⅱ组肉仔鸡的平均体重、日增重、免疫器官重量及其指数均不同程度高于同期空白对照组和抗生素组,其中平均体重与日增重多差异显著(P<0.05),部分免疫器官重量与指数有统计学意义(P<0.05);平均料重比均较明显地低于同日龄空白对照组和抗生素组。试验结果表明,基础日粮添加20、40mg/kg低聚壳聚糖对肉鸡的生长性能及免疫器官发育具有较明显的促进作用,可提高肉鸡的平均日增重和饲料转化率,增强机体的免疫功能。 相似文献
26.
爱拔益加肉鸡红细胞免疫吸附性能的研究 总被引：2，自引：0，他引：2
应用红细胞C3b受体花环(C3b Receptor Rosette,C3bRR)和复合物花环(Immune Complex Rosette,ICR)试验证实爱拔益加肉鸡红细胞表面存在补体C3b受体(C3bR),表明红细胞免疫系统RCIS(Red Cell Immune System)的概念适用于这种动物.文中对红细胞C3bRR和ICR分别代表红细胞表面C3bR"空位"和"占位"状态的含义作出了解释. 相似文献
27.
You-shi Liu You-hong Fang Ling-xiang Ruan You-ming Li Lin Li Ling-ling Jiang 《Journal of Zhejiang University. Science. B》2009,10(8):631-634
Takayasu’s arteritis (TA), also known as the “pulseless disease,” is a chronic vasculitis of the aorta and aortic branches.
TA with Crohn’s disease is rare and has not been documented in China before. In this paper we report on a case of Takayasu’s
arteritis associated with concurrent Crohn’s disease. A 17-year-old Chinese male developed upper limb sourness and a sensation
of fatigue, and his upper limb pulses were absent. He was diagnosed with TA and underwent an axillary artery bypass with autologous
great saphenous vein on the left subclavian artery. After the surgery, he regained the normal blood pressure. This patient
also had years of diarrhea and developed an anal canal ulcer, and was diagnosed with inflammatory bowel disease and ulcerative
colitis before. Five months after the TA surgery, he was hospitalized for severe stomachache and diarrhea and was finally
diagnosed with Crohn’s disease. The possible pathophysiological mechanisms responsible for concurrent existence of TA and
Crohn’s disease may be associated with immune disorders, especially autoimmunity.
相似文献
28.
You-shi LIU You-hong FANG Ling-xiang RUAN You-ming LI Lin LI Ling-ling JIANG 《Journal of Zhejiang University. Science. B》2009,10(8)
Takayasu's arteritis (TA), also known as the "pulseless disease," is a chronic vasculitis of the aorta and aortic branches. TA with Crohn's disease is rare and has not been documented in China before. In this paper we report on a case of Takayasu's arteritis associated with concurrent Crohn's disease. A 17-year-old Chinese male developed upper limb sourness and a sensation of fatigue, and his upper limb pulses were absent. He was diagnosed with TA and underwent an axillary artery bypass with autolo-gous great saphenous vein on the left subclavian artery. After the surgery, he regained the normal blood pressure. This patient also had years of diarrhea and developed an anal canal ulcer, and was diagnosed with inflammatory bowel disease and ulcerative colitis before. Five months after the TA surgery, he was hospitalized for severe stomachache and diarrhea and was finally diagnosed with Crohn's disease. The possible pathophysiological mechanisms responsible for concurrent existence of TA and Crohn's disease may be associated with immune disorders, especially autoimmunity. 相似文献
29.
Enhancing cellular immune response to HBV M DNA vaccine in mice by codelivery of interleukin-18 recombinant 总被引：1，自引：0，他引：1
INTRODUCTIONChronicinfectionwithHBVaffectsmorethan250millionpeopleworldwide.Therearemorethan120millionchronicHBVcarriersinChina;appro-ximately10percentofthemremaininstateofchronichepatitisandhaveahighriskofdevelop-mentofcirrhosisandhepatocellularcarcinoma.ButthereisnoeffectivemethodtocontrolchronicHBVinfectionatpresent.Recentdataindicatedthatim-munotherapeuticstrategiesstimulatingbothcellularandhumoralimmuneresponsestoHBVantigensareessentialforcuringchronicHBVinfection(ChisariandFe… 相似文献
30.
INTRODUCTION As a new effective mathematical tool to deal with vagueness and uncertainty, the rough set theory was first proposed by Pawlak in 1982. Theoretical research on rough set theory is characterized by many achievements (Dai, 2004b; 2005; Dai et al., 2004). In recent years rough set theory has been successfully applied in many fields such as machine learning, pattern recognition, decision support and data mining. But rough set theory cannot deal with continuous attributes althoug… 相似文献