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INTRODUCTION Voltage security control as an indispensable fa- cility in power systems aims at mid or long term voltage quality maintenance of power systems in the presence of load and/or transmission line disturbances. Most results of earlier research have been reported on transient stabilization and network control for voltage security of power systems, with various techniques originated from modern control methodology such as dynamic programming (Popovic et al., 2002; Wu et al., 2001), … 相似文献
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复合维生素添加剂对高温期淮北麻鸡生产性能和免疫功能的影响 总被引：1，自引：0，他引：1
目的:研究饲粮中添加不同水平的复合维生素添加剂对淮北麻鸡生产性能和免疫功能的影响及其相关性。方法:选取480只28周龄淮北麻鸡,随机分为4组,每组3个重复,每个重复40只鸡,饲喂在基础日粮分别添加复合维生素添加剂0(Ⅰ组,对照组)、100 mg/kg(Ⅱ组)、500 mg/kg(Ⅲ组)、1000 mg/kg(Ⅳ组),预试期2周,正试期8周。结果:与对照组比较,1)Ⅲ、Ⅳ组产蛋率比显著提高(P0.05),料蛋比显著降低(P0.05),蛋的受精率、孵化率及出雏率显著提高(P0.05);而Ⅱ组产蛋率、料蛋比、蛋孵化率和出雏率的变化不显著(P0.05);2)Ⅲ、Ⅳ组中血清免疫球蛋白A(Ig A)、免疫球蛋白M(Ig M)和补体C4含量显著提高(P0.05);而Ⅱ组中以上指标含量变化不显著(P0.05);3)Ⅲ、Ⅳ组血清超氧化物歧化酶活性和血清谷胱甘肽过氧化物酶活性及总抗氧化能力明显提高(P0.05),而Ⅱ组变化不明显(P0.05)。结论:饲粮中添加500~1000 mg/kg复合维生素添加剂能提高热应激条件下淮北麻鸡的生产性能、抗氧化能力和免疫功能。 相似文献
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《Public Library Quarterly》2013,32(3-4):119-137
Abstract Despite well-publicized advances in the development of antiretroviral therapies, HIV infection remains an incurable condition. Worldwide, the disease threatens to gravely impact a wide range of developing nations, especially in Sub-Saharan Africa, South and Southeast Asia and South America. In the United States, the poor and particularly women of color are at great, and increasing, risk for infection. Public libraries, as trusted public institutions for the dissemination of information, can continue to play an important role in promoting public health information surrounding HIV/AIDS prevention and education. Public libraries are not immune, however, to the political and value-driven public discourse surrounding HIV infection. Through carefully identifying the issues, taking a nonjudgmental service approach, and building collaborations with community based organizations, public libraries can become common ground for providing proactive prevention-focused information services. This article examines the current state of epidemic HIV/AIDS infection, reviews the literature on public library responses, and identifies highly select consumer health and biomedical monographic, serial, audio-visual and Web-based HIV/AIDS information tools. 相似文献
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目的：应用唾液中分泌型免疫球蛋白（sIgA）的含量指标评定免疫机能；方法：收集整理文献，找到合理的理论依据和分析方案；结果：唾液中sIgA作为分析免疫机能简易指标在指导运动训练和大众健身方面都有重要意义；运动员长期大强度训练可能会导致免疫力下降。这可以从唾液中sIgA含量反映。结论：可以通过唾液中sIgA含量及时调整运动量和强度、合理膳食来预防和缓解机体免疫的下降；对大众健身方面，可以通过分析sIgA的含量监控机体免疫状况，为科学的健身提供客观指标以指导实践。 相似文献
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建立了动态车辆路径优化问题的数学模型,提出了一种基于聚集密度的人工免疫多目标进化算法。该算法首先计算群体中每个个体的聚集密度,再根据目标函数值和聚集密度定义一个偏序集,然后采用比例选择原则依次从偏序集中选择个体,更新精英集。实验结果表明,该算法是解决动态车辆路径问题的有效方法。 相似文献
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传统人工免疫方法中对自体的定义不是动态的,这并不符合真实的系统环境。因为随着时间的积累,有些正常与异常的区别会变小,甚至相互转化。所以,必须根据环境的变化动态调整自体集。另外,采用有限差异变异和基因重排机制产生初始检测器集,将遗传算法引入到成熟检测器的免疫进化过程中,由于遗传算法具有良好的全局寻优能力,可有效地提高优质成熟检测器的产生并缩短成熟时间。基于KDDcup数据集上的仿真实验结果证明了本方法在检测异常和入侵方面能表现出良好的性能。 相似文献
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Although the biochemical dissection of parasitoid-host interactions is becoming well characterized, the molecular knowledge concerning them is minimal. In order to understand the molecular bases of the host immune response to parasitoid attack, we explored the response of Papilio xuthus parasitized by the endoparasitic wasp Pteromalus puparum using proteomic approach. By examining the differential expression of plasma proteins in the parasitized and unparasitized host pupae by two-dimensional (2D) electrophoresis, 16 proteins were found to vary in relation to parasitization compared with unparasitized control samples. All of them were submitted to identification by mass spectrometry coupled with a database search. The modulated proteins were found to fall into the following functional groups: humoral or cellular immunity, detoxification, energy metabolism,and others. This study contributes insights into the molecular mechanism of the relationships between parasitoids and their host insects. 相似文献
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An immune-tabu hybrid algorithm for thermal unit commitment of electric power systems 总被引：1，自引：0，他引：1
This paper presents a new method based on an immune-tabu hybrid algorithm to solve the thermal unit commitment （TUC） problem in power plant optimization. The mathematical model of the TUC problem is established by analyzing the generating units in modem power plants. A novel immune-tabu hybrid algorithm is proposed to solve this complex problem. In the algorithm, the objective function of the TUC problem is considered as an antigen and the solutions are considered as antibodies, which are determined by the affinity computation. The code length of an antibody is shortened by encoding the continuous operating time, and the optimum searching speed is improved. Each feasible individual in the immune algorithm （IA） is used as the initial solution of the tabu search （TS） algorithm after certain generations of IA iteration. As examples, the proposed method has been applied to several thermal unit systems for a period of 24 h. The computation results demonstrate the good global optimum searching performance of the proposed immune-tabu hybrid algorithm. The presented algorithm can also be used to solve other optimization problems in fields such as the chemical industry and the power industry. 相似文献
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Establishment of a production process for a novel vaccine candidate against Lawsonia intracellularis
BackgroundLawsonia intracellularis remains a problem for the swine industry worldwide. Previously, we designed and obtained a vaccine candidate against this pathogen based on the chimeric proteins: OMP1c, OMP2c, and INVASc. These proteins formed inclusion bodies when expressed in E. coli, which induced humoral and cellular immune responses in vaccinated pigs. Also, protection was demonstrated after the challenge. In this study, we established a production process to increase the yields of the three antigens as a vaccine candidate.ResultsBatch and fed-batch fermentations were evaluated in different culture conditions using a 2 L bioreactor. A fed-batch culture with a modified Terrific broth medium containing glucose instead of glycerol, and induced with 0.75 mM IPTG at 8 h of culture (11 g/L of biomass) raised the volumetric yield to 627.1 mg/L. Under these culture conditions, plasmid-bearing cells increased by 10% at the induction time. High efficiency in cell disruption was obtained at passage six using a high-pressure homogenizer and a bead mill. The total antigen recovery was 64% (400 mg/L), with a purity degree of 70%. The antigens retained their immunogenicity in pigs, inducing high antibody titers.ConclusionsConsidering that the antigen production process allowed an increment of more than 70-fold, this methodology constitutes a crucial step in the production of this vaccine candidate against L. intracellularis.How to cite: Salazar S, Gutiérrez N, Sánchez O, et al. Establishment of a production process for a novel vaccine candidate against Lawsonia intracellularis. Electron J Biotechnol 2021.https://doi.org/10.1016/j.ejbt.2021.01.002 相似文献