Relationship between alanine aminotransferase levels and metabolic syndrome in nonalcoholic fatty liver disease     

Chen ZW  Chen LY  Dai HL  Chen JH  Fang LZ 《Journal of Zhejiang University. Science. B》2008,9(8):616-622

Objective:To investigate the relationship between alanine aminotransferase (ALT)levels and metabolic syndrome (MS)in nonalcoholic fatty liver disease(NAFLD).Methods:A total of 26527 subjects who received medical health checkup in our hospital from January 2005 to July 2007 were enrolled in the study.The diagnosis of fatty liver was based on ultrasound imaging.MS Was defined according to the criteria of the Adult Treatment Panel Ⅲ.ALT,triglyceride(TG),high density lipoprotein cholesterol(HDL-c),fasting plasma glucose(FPG),height,weight,waist circumference(WC),systolic blood pressure (SBP)and diastolic blood pressure(DBP)were measured in each subject to analyze the relationship between MS and ALT activity.Results:(1)The prevalence of NAFLD in men(30.94%)was significantly higher than that in women(15.65%);(2)The incidence of MS in NAFLD(33.83%)was significantly greater than that in non-NAFLD(10.62%);(3)Of the 6470 subjects with NAFLD,in the age-adjusted partial correlation analysis,there were statistically significant correlations between the ALT levels and most metabolic risk factors in each sex(P＜0.01),except that ALT levels had no correlation with HDL-c in women.Moreover,in the multiple stepwise regression analysis,SBP lost its significance,and WC,body mass index(BMI),age,DBP,TG and FPG were independently associated with ALT levels in both sexes (P＜0.05).HDL-c remained significant and was independently related to ALT leveis in men;(4)ALT levels were significantly higher in subjects with MS compared to those without MS(P＜0.001).Mean ALT levels increased with the number of MS cornponents in each sex (P.＜0.05 for trend).Conelusion:We found a strong relationship between ALT leveIs and MS in NAFLD and revealed that the cluster of MS components might be the predictor for ALT elevations.  相似文献   

肝癌的光动力治疗及其进展     

廖昱博  刘明辉 《赣南师范学院学报》2007,28(6):18-21

光动力疗法(PDT)是利用光敏剂在肿瘤组织中聚集的浓度大于正常组织,通过适当波长与足够能量的光激发,触发光敏剂的光化学反应,产生大量的启动单态氧,从而达到杀伤肿瘤细胞的作用.本文主要介绍了肝癌的光动力疗法及其疗效,报道了该领域最近所取得的一些重要进展,并对该疗法的发展前景作出了展望.研究表明,光动力疗法治疗肝癌具有适应症宽,创伤小,安全有效,生存质量好等优点,值得临床推广应用.  相似文献   

獒肉与狗肉营养价值的测定与比较     

牟红梅  冯宝民  李红娜  曹杨  陈永燕  王永奇 《大连大学学报》2004,25(6):45-48

对獒肉和狗肉中的蛋白质、氨基酸、脂肪、总糖、和脂肪酸几种生物大分子含量进行了初步分析.结果表明:獒肉中蛋白质含量15.53％,家狗肉蛋白质含量14.19%,獒的总脂肪含量30.50％,狗的脂肪含量20.31％.獒的总糖含量1.59％,狗的总糖含量1.43％,17种氨基酸中人体必需氨基酸含量均略高,其中赖氨酸的含量獒是狗的近三倍.脂肪酸含量均非常丰富,其中油酸含量达40％多.獒与狗的部分指标含量差异明显.  相似文献   

保肝弥毒胶囊治疗抗精神病药物所致肝损害   总被引：2，自引：0，他引：2  

杜晖  袁群  熊炳才 《荆门职业技术学院学报》2001,16(6):68-69

利用保肝弥毒胶囊治疗抗精神病药物所致肝脏损害40例,并与肝泰乐和肌苷片联合治疗组作对照观察,疗程为4周.结果显示在治疗两周时两组疗效相当,在4周时,保肝弥毒胶囊治疗组疗效显著高于对照组.  相似文献   

一种结构性能关系研究的新方法     

王克强 《嘉应学院学报》1996,(6):41-45

根据分子拓扑学原理,用距离矩阵和染色矩阵描述分子结构,用染色因子和形状因子标识原子性质的差异,发展了一种结构性能关系研究的新方法,对138种脂肪酯的计算结果表明,该方法具有良好的结构区分性和性能相关性。  相似文献   

Metabonomic analysis of hepatitis B virus-induced liver failure: identification of potential diagnostic biomarkers by fuzzy support vector machine     

Yong MAO  Xin HUANG  Ke YU  Hai-bin QU  Chang-xiao LIU  Yi-yu CHENG 《Journal of Zhejiang University. Science. B》2008,9(6):474-481

Hepatitis B virus (HBV)-induced liver failure is an emergent liver disease leading to high mortality. The severity of liver failure may be reflected by the profile of some metabolites. This study assessed the potential of using metabolites as biomarkers for liver failure by identifying metabolites with good discriminative performance for its phenotype. The serum samples from 24 HBV-induced liver failure patients and 23 healthy volunteers were collected and analyzed by gas chromatography-mass spectrometry (GC-MS) to generate metabolite profiles. The 24 patients were further grouped into two classes according to the severity of liver failure. Twenty-five commensal peaks in all metabolite profiles were extracted, and the relative area values of these peaks were used as features for each sample. Three algorithms, F-test, k-nearest neighbor (KNN) and fuzzy support vector machine (FSVM) combined with exhaustive search (ES), were employed to identify a subset of metabolites (biomarkers) that best predict liver failure. Based on the achieved experimental dataset, 93.62% predictive accuracy by 6 features was selected with FSVM-ES and three key metabolites, glyceric acid, cis-aconitic acid and citric acid, are identified as potential diagnostic biomarkers.  相似文献   

由混合粗脂肪酸制生物柴油     

阮林叶  ;盛梅  ;曹国民 《温州大学学报(社会科学版)》2008,(3):28-32

以高碳混合粗脂肪酸和甲醇为原料制备生物柴油．研究了醇酸摩尔比、反应温度、反应时间、催化剂等因素对反应的影响．实验结果表明,最适宜工艺条件为：醇酸摩尔比5：1,反应温度70℃,反应时间6h,催化剂用量1．5％（以原料中脂肪酸质量为基准）,甲醇分三次加入．由高碳混合粗脂肪酸制备的生物柴油,其各项技术指标与国外同类产品标准接近．  相似文献   

芪蚣抗纤方对免疫性肝纤维化大鼠肝组织病理形态的影响   总被引：4，自引：0，他引：4  

陈桂敏  郑文芝  薛贵平  刘丰熙  薄爱华 《河北北方学院学报(医学版)》2005,22(4):3-6

目的:通过用芪蚣抗纤方(QF)对免疫损伤性肝纤维化大鼠治疗前后肝组织病理结构变化的观察,进一步阐明QF抗免疫性肝纤维化机理.方法:采用猪血清腹腔注射法持续8周诱导大鼠免疫性肝纤维化模型,然后应用QF灌胃治疗四周,第十二周起,分批处死动物,取肝组织,常规制备石蜡切片和超薄切片,并对石蜡切片进行HE染色、胶原纤维特殊染色(Mallory)和免疫组织化学染色.光镜及透射电镜观察.结果: QF高低剂量治疗组较模型组肝细胞损伤都有不同程度好转,胶原纤维明显减少.结论:QF可能有保护和修复受损的肝细胞,抑制胶原纤维的形成,具有抗免疫损伤性肝纤维化作用.  相似文献   

利用气相色谱/质谱联合技术研究核桃仁油脂酸组成   总被引：2，自引：0，他引：2  

郑敏燕  魏永生  耿薇 《咸阳师范学院学报》2006,21(4):26-28,32

分别以乙醚、正己烷为溶剂,采用索氏提取法和超声波提取法对核桃仁中的核桃油进行提取。用两种甲酯化方法对核桃油进行处理,通过GC/MS方法分析了核桃油中脂肪酸的组成和含量。从核桃油中共检出13种脂肪酸,除亚油酸等5种文献报道过的主要成分外,还包括十四烷酸(肉豆寇酸)、十五烷酸、十六碳烯酸、十六碳二烯酸、十七烷酸、二十烷酸(花生酸)以及二十碳烯酸和二十碳三烯酸等8种含量较少的成分,约占核桃油脂肪酸总量的1.7%。  相似文献   

乌索酸对D-氨基半乳糖致小鼠急性肝损伤的影响     

熊筱娟  肖小华  陈武  易增兴 《宜春学院学报》2005,27(4):1-2,9

目的：研究乌索酸抗急性肝损伤的作用．方法：利用D-氨基半乳糖（D-GalN）建立小鼠急性肝损伤病理模型，分别以乌索酸按15、30、60mg／kg小鼠口服给药，观察其对急性肝损伤小鼠血清丙氨酸氨基转移酶（ALT）、天门冬氨酸氨基转移酶（AST）、肝组织丙二醛（MDA）含量及肝脏形态学的影响．结果：急性肝损伤模型组与正常对照组比较，各项指标差异均有显著性（P〈0．01）；乌索酸组与模型组比较，血清ALT、AST、MDA明显降低（P〈0．05），光镜下肝细胞脂肪变性、水样变性明显减轻；结论：乌索酸对D—GalN所致的急性肝损伤小鼠具有保护作用．  相似文献