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孩子的耳朵每天都在接受来自电视、电脑、收音机、街道上的车辆等喧闹声的轰炸。虽然大部分声音是无害的,但是那些超过一定分贝、并且持续时间长的噪声则会永久性地损伤孩子的听力。在3月3日,世界爱耳日来临之际,我们向家长提出倡议,要像爱护孩子的眼睛一样,爱护孩子的耳朵。 相似文献
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孩子的耳朵每天都在接受来自电视、电脑、收音机、街道上的车辆等喧闹声的轰炸。虽然大部分声音是无害的，但是那些超过一定分贝、并且持续时间长的噪声则会永久性地损伤孩子的听力。
在3月3日，世界爱耳日来临之际，我们向家长提出倡议，要像爱护孩子的眼睛一样，爱护孩子的耳朵。[编按] 相似文献
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INTRODUCTIONHeadandneckcancersquamouscellcarci noma (HNSCC)isthefifthmostfrequentmalig nantneoplasmworld wide ;andischaracterizedbylocalinvasion ,disseminationtolocallymphnodeandfrequentrecurrenceattheprimarysiteoftumour.Despiteimprovementsindiagnosisandt… 相似文献
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This study aimed to explore the molecular mechanism in tumor invasion and metastasis. The expression of matrix metalloproteinase-2,
−9 (MMP-2, MMP-9), tissue inhibitor-1 of matrix metalloproteinase (TIMP-1), cell adhesion molecule 44 variant 6 (CD44v6),
HER2/neu and p53 was investigated in 154 patients with head and neck squamous cell carcinoma (SCC) by ABC and ImmunoMax immunohistochemical
method. Their clinical relevance and correlation were analysed. The expression of MMP-2, MMP-9, TIMP-1, CD44v6, HER2/neu and
p53 was found in cancer cells in 87.01%, 85.71%, 68.18%, 98.05%, 55.19% and 50.65% cases respectively. Linear regression and
correlation analysis revealed that there was close positive relationship (P<0.05) between the expression of MMP-2 and MMP-9, TIMP-1 and CD44v6, HER2/neu and MMP-9, MMP-2 and p53. Up-regulation of MMP-2
was accompanied by advanced T stage (P<0.01). There was also a trend of MMP-2 expression being related with tumor metastasis. Increased expression of HER2/neu was
found in patients with tumor recurrence (P<0.05). The expression of TIMP-1 was higher in laryngeal cancer than that in pharyngeal cancer, and higher in keratinizing
and non-keratinizing SCC than that in basaloid SCC (P<0.05). These findings suggested that MMP-2 and MMP-9, HER2/neu and MMP-9, MMP-2 and p53 had a coordinate function in aggression
of tumor; that MMP-2 had a more important function than MMP-9 in tumor invasion and metastasis; and that HER2/neu might serve
as a biomarker for poor prognosis in HNSCC.
Project supported by Lübeck Medical University, Germany 相似文献
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