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ＩＮＴＲＯＤＵＣＴＩＯＮＦｉｂｒｏｂｌａｓｔｇｒｏｗｔｈｆａｃｔｏｒ (ＦＧＦ)ｉｓａｎａｎｇｉｏ ｇｅｎｉｃａｎｄｍｉｔｏｇｅｎｉｃｐｏｌｙｐｅｐｔｉｄｅｔｈａｔｃａｎｐｒｏｍｏｔｅｃｅｌｌｐｒｏｌｉｆｅｒａｔｉｏｎａｎｄｄｉｆｆｅｒｅｎｔｉａｔｉｏｎｉｎａｗｉｄｅｖａ ｒｉｅｔｙｏｆｃｅｌｌｔｙｐｅｓ (Ｇｏｌｄｆａｒｂ ,1 990 ;Ｂａｓｉｌｉｃｏｅｔａｌ.,1 992 ) .ＴｈｅＦＧＦｆａｍｉｌｙｈａｓｍａｎｙｍｅｍｂｅｒｓｗｉｔｈｓｉｍｉｌａｒａｍｉｎｏａｃｉｄｓｅｑｕｅｎｃｅａｎｄｂｉｏｌｏｇｉｃａｌａ… 相似文献
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蜂王浆生理药理作用研究现状 总被引：11，自引：0，他引：11
1 前言蜂王浆是青年工蜂 ( 5- 15日龄的哺育工蜂 )的舌腺和上颚腺的分泌物。它是哺育蜂用以哺育蜂王幼虫 ,喂饲蜂王成虫及哺育 3日龄以内工蜂和雄蜂幼虫的浆状物 ,类似哺乳动物的乳汁 ,所以又叫蜂乳、王浆、蜂皇浆。由同一只蜂王产下的受精卵发育成的幼虫若在整个幼虫期都喂蜂王浆 ,只需 16天就发育成性器官完全的蜂王 ;若在前三天喂蜂王浆 ,之后喂蜂粮 (蜂蜜和花粉的混合物 ) ,2 1天后才发育成性器官不完全的工蜂。蜂王体重是工蜂的 3倍 ,寿命可达工蜂的 50倍左右。工蜂寿命一般为 30～ 60天 ,即使在冬季也只有 6～ 8个月 ,而蜂王的寿命是… 相似文献
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Human acidic and basic fibroblast growth factors (aFGF and bFGF) are classic and well characterized members of the heparin-binding
growth factor family. Heparin is generally thought to play an extremely important role in regulating aFGF and bFGF bioactivities
through its strong binding with them. In order to unravel the mechanism of the interactions between heparin and FGFs, and
evaluate the importance of heparin sulfate groups' binding with FGFs, surface plasmon resonance analyses were performed using
IAsys Cuvettes System. Heparin and its regioselectively desulfated derivatives were immobilized on the cuvettes. aFGF and
bFGF solutions with different concentrations were pipetted into the cuvettes and the progress of the interaction was monitored
in real-time by Windows-based software, yielding kinetic and equilibrium constants for these interactions. In addition, in
order to reduce the delicate difference among the cuvettes, inhibition analyses of mixtures of FGFs and immobilized native
heparin by modified heparins were also done. The data from these two methods were similar, indicating that all sulfate groups
at 2-O, 6-O and N- in heparin were required for the binding to aFGF; and that their contribution to the binding was in the
order 2-O, N- and 6-O-sulfate group. In contrast, definite contribution of the 6-O-sulfate group to the binding with bFGF
was most apparent, while the other two sulfate groups appeared to be necessary in the order 2-O and N-sulfate group. These
methods established here can be used for analysing the effect of sulfate groups in heparin on the binding with other human
FGF members or other heparin-binding proteins.
The project supported by the Scientific Research Foundation for Returned Overseas Chinese Scholars, State Education Ministry
of China and Zhejiang Provincial Natural Science Foundation of China (301306) 相似文献
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