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The functions of the eukaryotic cell rely onmembrane-bound compartments called organelles. Each of these possesses distinct membrane composition and unique function. In the 1970’s, during George Palade’s time, it was unclear how these organelles communicate with each other and perform their biological functions. The elegant research work of James E Rothman, Randy W Schekman and Thomas C Südhof identified the molecular machinery required for membrane trafficking, vesicle fusion and cargo delivery. Further, they also showed the importance of these processes for biological function. Their novel findings helped to explain several biological phenomena such as insulin secretion, neuron communication and other cellular activities. In addition, their work provided clues to cures for several neurological, immunological and metabolic disorders. This research work laid the foundation to the field of molecular cell biology and these post-Palade investigators were awarded the Nobel Prize in Physiology or Medicine in 2013. 相似文献
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Amrith Bdr Subba Chokey Yangzom Karma Dorji Sangye Choden Ugyen Namgay 《International Journal of Inclusive Education》2019,23(1):42-64
ABSTRACTBhutanese educators are facing the challenge of implementing inclusive education for students with disability throughout their schooling system. Selected schools have started to implement inclusive policies and practices, and it is timely to investigate the progress of inclusive education in these schools. In this qualitative study, 14 Bhutanese principals responded to questions regarding inclusive practices in their schools. Responses were divided into two broad categories: the current status of inclusion in their school; and, inclusion in the future. Principals described barriers such as a lack of specialised teachers, inadequate resources and facilities, and a lack of holistic inclusion. However, they also noted that students were accepted by their peers, that the schools were working well with what they have, and that there was a positive attitude for the future. Changes that are required to progress inclusive education in Bhutan from the perspective of the principals are discussed. The findings of this research will be of interest to researchers and leaders in schools and ministries of education who are working to promote more inclusive schools in less developed countries. 相似文献
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Sunil S. Amrith 《Inter-Asia Cultural Studies》2013,14(4):557-569
Abstract This paper argues that two conflicting discourses of internationalism stood in uneasy counterpoint and contention in the Asian arena of the 1950s, reflected in the legacies of the Bandung conference. The first drew on a language of global citizenship and rights. The second saw the international system as a source of strength and support for state sovereignty, and state‐directed programmes of national development. The remainder of the paper uses the case of late‐colonial Singapore to examine the intersection of these two discourses of internationalism. An Asian internationalism, which spanned to include Africa over the course of the 1950s, became one of a stock of narratives that made Singapore’s ‘everyday cosmopolitanism’ possible, in the worlds of the hawkers, the dockworkers and the agriculturalists. The political aspirations of these groups were sacrificed, ultimately, to the goal of disciplined national development, supported by an international order that had closed in to defend the interests of state power. 相似文献
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锡金喜马拉雅地区是全球重要的生物多样性热点地区之一,该地区的农业生产系统最近已经被推荐作为联合国粮农组织（FAO）全球重要农业文化遗产（GIAHS）保护的候选地。在这一地区,集中体现了被称为Demazong（稻米之谷）或香格里拉（消失的地平线）的神圣景观。这个神圣的、多样性的文化景观中,当地少数民族社区利用传统的生态知识对极为丰富的农业生物多样性进行适应和管理。多样化的农业生态系统,包括位于高山地区农牧复合系统Dokpas,位于温带地区的传统的农林复合系统（如桤木-草本混交农业系统）,以及海拔较低的暖温带到亚热带农业气候区的梯田/谷地稻作系统。将富含文化多样性和生物多样性的土地利用系统与景观进行边缘化是一件十分荒谬的事情。但值得说明的是,尽管这里有着巨大的发展潜力,却长期存在着贫穷、进入市场困难、经济和生态较为脆弱等问题。
锡金喜马拉雅地区的农业是一种典型的适应性管理系统,具有重要的生态系统服务功能,提供了具有重要经济价值的多样化的农作物品种,以及适应明显垂直分异农业生态区的多用途的植物物种。在那里生活着的不同的土著社区,依然保持着传统的生态知识,以适应、监测和响应生态系统的恢复能力与生态系统的服务功能。在本文中,我们探讨了传统农业在生物多样性保护中的作用,评估了从亚热带到高原农业生态区的多样性的生态系统管理途径,分析了对于农业生态系统的社会适应性与知识基础以及传统体制在促进该地区农业生产系统通过GIAHS在地区、国家和全球水平上获得更加广泛的认可的作用。我们认为,为减轻气候变化的可能影响和应对可能的新挑战,应当采用参与式的方式对传统农业进行监测,并制定科学的政策。锡金喜马拉雅地区的传统农业被认定为全球重要农业文化遗产,将有助于促进这一传统农业系统的保护,促进边际社区的环境健康和生计的可持续性,确保该地区的可持续发展。 相似文献
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