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Walter Hahn Guy Cellerier Wolfgang Wilhelm Jindra Kulich Robert J. Havighurst Bryan T. Peck Annegret Körner Rodney Skager Renate Nestvogel J. H. Sislian John J. Bergen Peter W. Kahl Tony Bates 《International Review of Education/Internationale Zeitschrift für Erziehungswissenschaft/Revue internationale l'éducation》1978,24(4):523-544
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Annegret Mündermann Jeroen Geurts Thomas Hügle Thomas Nickel Arno Schmidt-Trucksäss Martin Halle 《Journal of sports sciences》2017,35(7):711-718
We tested the hypothesis that changes in serum cartilage oligomeric matrix protein (COMP), tumour necrosis factor α (TNF-α), interleukin-6 (IL-6) and high-sensitivity C-reactive protein (hsCRP) concentration after regular endurance training and running a marathon race depend on body mass index (BMI) and/or on marathon performance. Blood samples were collected from 45 runners of varying BMI and running experience before and after a 10-week marathon training programme and before, immediately and 24 h after a marathon race. Serum biomarker concentrations, BMI and marathon finishing time were measured. The mean (95% confidence interval (CI)) changes from before to immediately after the marathon were COMP: 4.09 U/L (3.39–4.79 U/L); TNF-α: ?1.17 mg/L (?2.58 to 0.25 mg/L); IL-6: 12.0 pg/mL (11.4–12.5 pg/mL); and hsCRP: ?0.08 pg/mL (?0.14 to ?0.3 pg/mL). The mean (95% CI) changes from immediately after to 24 h after the marathon were COMP: 0.35 U/L (?0.88 to 1.57 U/L); TNF-α: ?0.43 mg/L (?0.99 to 0.13 mg/L); IL-6: ?9.9 pg/mL (?10.5 to ?9.4 pg/mL); and hsCRP: 1.52 pg/mL (1.25–1.79 pg/mL). BMI did not affect changes in biomarker concentrations. Differences in marathon finishing time explained 32% of variability in changes in serum hsCRP and 28% of variability in changes in serum COMP during the 24 h recovery after the marathon race (P < 0.001). Slower marathon finishing time but not a higher BMI modulates increases in pro-inflammatory markers or cartilage markers following a marathon race. 相似文献
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