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Farrokhi E Shayesteh F Asadi Mobarakeh S Roghani Dehkordi F Ghatreh Samani K Hashemzadeh Chaleshtori M 《Indian journal of clinical biochemistry : IJCB》2011,26(3):244-248
Familial hypercholesterolemia (FH) is an autosomal dominant disorder of lipoprotein metabolism caused mainly by mutations
in the low-density lipoprotein receptor (LDLR) and apolipoprotein B 100 (APOB) genes. Until now, the molecular basis of FH
has been demonstrated in detail in many populations, but there is still very limited Molecular data concerning FH in Iran.
The aim of this study was to characterize the LDLR and APOB gene mutations in an Iranian population. A total of 30 non-related
Iranian possible FH subjects were studied. Diagnosis of FH was based on the Dutch Lipid Clinic Network diagnostic criteria.
All samples were initially tested for three common APOB gene mutations including R3500Q, R3500 W and R3531C using PCR-RFLP
assay. Subsequently, promoter and coding region of the LDLR gene was screened by PCR-SSCP analysis and positive results were
confirmed by DNA sequencing. Four previously reported polymorphisms 1413G > A, 1725C > T, 1773T > C and 2140 + 5G > A were
found in ~17% (5/30) of population studied. Moreover, no variation was found in APOB gene. Our data indicated that LDLR and
APOB gene mutations have not contribution to possible FH in Iranian population studied here. However, we examined three common
APOB mutations and LDLR in only 30 patients, and to determine the role of these genes in developing FH in Iran, more FH samples
and populations needed to be investigated for the mutations of the related genes. 相似文献
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The contribution of linguistic and cognitive variables to reading processes might vary depending on the particularities of the languages studied. This view is thought to be particularly true for Arabic which is a diglossic language and has particular orthographic and morpho-syntactic systems. This cross-sectional study examined the contribution of phonological, orthographic, morphological, semantic, syntactic, visual perception, rapid automatic naming and phonological working memory abilities to decoding and fluency (the two components of reading). The results, obtained from 1305 native Arabic-speaking children in first–sixth grade, were analyzed using path models. The analysis revealed that memory and orthographic knowledge contributed to both components of reading, while phonological awareness contributed mainly to decoding and rapid automatic naming contributed to fluency. The contribution of morphology to the two components, which appeared already in the first grade, was weak and inconsistent. Finally, the results showed that visual perception, semantics, and syntax predicted neither decoding nor fluency. The data presented here suggest that reading development in Arabic differs from other languages, a finding that might explain certain difficulties in reading acquisition in Arabic. The results are discussed in the light of previous findings in the literature and the specific features of Arabic. 相似文献
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Abdolmotalleb Rezaei Ali Asadi Ahmad Rezvanfar Hajar Hassanshahi 《International Information and Library Review》2009,41(3):163-172
Information system success has been widely discussed in the past two decades. As systems and technologies are being improved and developed, discussions on their effectiveness and evaluation on their success have been continuously debated by researchers, scholars and practitioners throughout the years. Besides the major concern of IS effectiveness, factors influencing IS effectiveness are also important. One of these factors is the organizational factor. Using perceptual measures, this study aims to investigate the influence of organizational factors on MIS success. Survey questionnaires were gathered from 132 Extension Managers from Iran's Agricultural Extension Providers. Seven items were identified to influence MIS success. They are IS department structure, top management support, management style, managerial IT knowledge, goal alignment, resources allocation and IS infrastructure. The study also identified five MIS success dimensions; systems quality, information quality, perceived Ease of use, organizational impact and individual impact. The study found that the MIS success variables are significantly and highly correlated. The study also found all the organizational factors are significantly correlated to the five IS success factors investigated; the system quality, information quality, perceived ease of use, organizational impact and individual impact. Multiple regression analyses also found goal alignment as the highest predictor of IS success, followed by IS department structure, IS infrastructure and management style. 相似文献
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How simple is reading in Arabic? A cross‐sectional investigation of reading comprehension from first to sixth grade 
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下载免费PDF全文 - The ‘simple view of reading’ model explains reading comprehension as the product of decoding and listening comprehension.
- This model explains between 70% and 83% of the variance in reading comprehension in English, in which the contribution of decoding and listening comprehension varies as a function of the level of the readers.
- Orthographic transparency and other unique characteristics of the languages studied might influence reading comprehension in these languages
- Arabic is a diglossic language that is characterised by relatively unique orthographic and morphological features for which the validity of the simple view of reading (SVR) has not been tested.
- The basic components of the SVR (decoding and listening comprehension) have explained between 56% and 38% of the variance in reading comprehension in children from the first to the sixth grade.
- Decoding, as one of the basic components of the SVR, failed to contribute to reading comprehension when orthography and morphology were considered.
- This large‐scale cross‐sectional study is the first of its type to assess reading comprehension in Arabic.
- The study justifies the necessity to assess the suitability of the SVR in languages with very specific linguistic characteristics such as Arabic.
- The results emphasise the necessity of considering the complex orthography and the rich morphology of Arabic for improving teaching, assessment and intervention.
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We consider a multi-stage retrieval architecture consisting of a fast, “cheap” candidate generation stage, a feature extraction stage, and a more “expensive” reranking stage using machine-learned models. In this context, feature extraction can be accomplished using a document vector index, a mapping from document ids to document representations. We consider alternative organizations of such a data structure for efficient feature extraction: design choices include how document terms are organized, how complex term proximity features are computed, and how these structures are compressed. In particular, we propose a novel document-adaptive hashing scheme for compactly encoding term ids. The impact of alternative designs on both feature extraction speed and memory footprint is experimentally evaluated. Overall, results show that our architecture is comparable in speed to using a traditional positional inverted index but requires less memory overall, and offers additional advantages in terms of flexibility. 相似文献
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The aim of this study was to investigate the effects of maturation on power and sprint performance adaptations following 6 weeks of plyometric training in youth soccer players during pre-season. Sixty male soccer players were categorized into 3 maturity groups (Pre, Mid and Post peak height velocity [PHV]) and then randomly assigned to plyometric group and control group. Vertical jump, standing long jump, and 20-m sprint (with and without ball) tests were collected before- and after-intervention. After the intervention, the Pre, Mid and Post-PHV groups showed significant (P ≤ 0.05) and small to moderate effect size (ES) improvement in vertical jump (ES = 0.48; 0.57; 0.73), peak power output (E = 0.60; 0.64; 0.76), standing long jump (ES = 0.62; 0.65; 0.7), 20-m sprint (ES = ?0.58; ?0.66), and 20-m sprint with ball (ES = ?0.44; ?0.8; ?0.55) performances. The Post-PHV soccer players indicated greater gains than Pre-PHV in vertical jump and sprint performance after training (P ≤ 0.05). Short-term plyometric training had positive effects on sprinting and jumping-power which are important determinants of match-winning actions in soccer. These results indicate that a sixty foot contact, twice per week program, seems effective in improving power and sprint performance in youth soccer players. 相似文献
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Reading and Writing - In the original publication of the article formatting of Arabic words was incorrectly published. 相似文献
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The universal role of phonological processing skills for reading acquisition has been established in many different languages including Arabic. However, in Arabic little knowledge exists about the development of wide-range of phonological tasks and about the correlations between them. We longitudinally studied the developmental trends and correlations between different phonological tasks in kindergarten and first grade and tested their relation to reading accuracy and fluency. Thirty-two children individually completed the same ten phonological processing tasks in kindergarten and first grade. In first grade, reading measures and letter naming were also assessed. Developmental effects of phonological skills showed significant improvement of performance between the two phases in the majority of tasks. Task comparability has raised interesting issues related to the developmental hierarchy of phonological awareness tasks. Moreover, phonological awareness tasks were more inter-correlated in first grade compared to kindergarten, and their correlations to reading were also more established when phonological measures were collected in first grade. The developmental hierarchy of phonological tasks seems to depend on the linguistic and cognitive complexity (unit position, maintenance of the coherent unit and word length) of the items, beyond the size of the phonological unit which was manipulated. The observations reported here have practical implications for planning graded phonological instruction and intervention strategies.
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