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Ashish Rajadhyaksha 《Inter-Asia Cultural Studies》2013,14(4):608-624
AbstractWhen the Government of India declares its plan to convert Mumbai's Kala Ghoda art district into India's equivalent of Times Square, it does something that many Asian countries are doing in their understanding of the needs of the creative industry. In Mumbai's case, however, such an act has several additional historical echoes. This paper proposes that the origins of the so-called ‘creative class' lie in the failure of the city's historic 1982 textile strike, which saw the return of an artisanal practice to the city, often practiced by a class of casual labourers being forced to turn into low-end entrepreneurs without financial security. Such an artisanal entrepreneurship has had a far more complex relationship with industrialization than most theories recognize, and today's cultural industries are effectively replaying a longer history of this class in Bombay that may go back to pre-colonial and colonial times. The paper explores both the colonial and developmental interventions into this artisanal class as essential histories to understanding their new relationship to the ‘creative’ economy into which they are being presently inserted. 相似文献
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Bhanu P. Singh Banani Banerjee Puspanita Naik Jordan N. Fink Viswanath P. Kurup 《Indian journal of clinical biochemistry : IJCB》2006,21(2):20-27
The ubiquitous fungus Aspergillus fumigatus causes allergic rhinitis, asthma, sinusitis and allergic bronchopulmonary aspergillosis.
A number of major allergens from A. fumigatus are purified, but their structure-function role in the pathogenesis of disease
is not known. Such information is essential for devising alternative therapy of fungal allergic diseases. In the present study,
N-terminal and C-terminal deletion mutants ofAsp f 3 were constructed and their immunopathological responses studied in a mice model of allergy. Three mutants viz,Asp f 3 (aa 33–168), (aa 1–142), and (aa 23–142) were made by deleting certain amino acids from epitopic regions of full lengthAsp f 3, a major allergen of A. furnigatus. TheAsp f 3 and three mutated proteins were expressed in pET vector. The C-terminal deletion mutantAsp f 3 (aa 1–142) induced elevated IFN-γ but low levels of IL-4 by spleen cells. This mutant also showed significant downregulation
of peripheral blood eosinophils and lung inflammation in immunized mice. The N-terminal deletion mutantAsp f 3 (aa 33–168) also exhibited an immuno-suppressive effect in terms of IgE production and induction of Th2 cytokine. The results
indicate thatrAsp f 3 and its deletion mutants induced distinct immune-inflammatory responses in mice on challenge with these proteins. The non-IgE
binding deletion mutants ofAsp f 3 (aa 1–142 and aa 33–168) could deviate Th2 immune response with a concomitant reduction in airway inflammation and infiltration
of inflammatory cells. 相似文献
3.
Pillai K. R. Upadhyaya Pallavi Prakash Ashish Viswanath Ramaprasad Badrinarayan Srirangam Mukesh H. V. Pai Yogesh 《Education and Information Technologies》2021,26(4):3677-3698
Education and Information Technologies - The current study examines students’ coping process of a forced technological intervention in academic outcome assessment in a higher education... 相似文献
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Afzal Ahmad Rukmini Mysore Srikantiah Charu Yadav Ashish Agarwal Poornima Ajay Manjrekar Anupama Hegde 《Indian journal of clinical biochemistry : IJCB》2016,31(4):458-462
The cause of more insulin resistance in female than males are still unknown. To know the cause from early life, normal values of relevant parameters are required. So, aim of this study was to determine the reference levels of glucose and insulin in cord blood of term newborns and to examine their effects on gender, placental and birth weight of term newborns. In cross sectional study 60 consecutive term newborns were included from constituent hospitals. Placental and birth weights were measured and cord blood was collected for estimation of serum insulin and plasma glucose. Plasma glucose estimation was done by auto analyzer (GOD–POD method) and serum insulin analysis was done using Insulin ELISA Kit. After analysis, mean ± 2SD used for estimating cord blood insulin and glucose levels, which were 10.1 ± 7.8 μIU/mL and 67.8 ± 33.8 mg/dL respectively. Correlation of insulin with both birth weight and placental weight were r = 0.359 and 0.41 respectively; p < 0.001. Interestingly we found higher insulin levels in females as compared to male newborns in spite of having lower birth weight in them. In conclusion this study reported the levels of insulin and glucose in cord blood of term newborns. Incidentally, this is the first study as per our knowledge to report significant correlation between cord blood insulin, glucose with birth weight, placental weight and gender in south India. Female newborns had higher insulin levels than males, despite lesser birth weight can be attributed to intrinsic insulin resistance in them. 相似文献
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Anatomy has historically been a cornerstone in medical education regardless of nation or specialty. Until recently, dissection and didactic lectures were its sole pedagogy. Teaching methodology has been revolutionized with more reliance on models, imaging, simulation, and the Internet to further consolidate and enhance the learning experience. Moreover, modern medical curricula are giving less importance to anatomy education and to the acknowledged value of dissection. Universities have even abandoned dissection completely in favor of user‐friendly multimedia, alternative teaching approaches, and newly defined priorities in clinical practice. Anatomy curriculum is undergoing international reformation but the current framework lacks uniformity among institutions. Optimal learning content can be categorized into the following modalities: (1) dissection/prosection, (2) interactive multimedia, (3) procedural anatomy, (4) surface and clinical anatomy, and (5) imaging. The importance of multimodal teaching, with examples suggested in this article, has been widely recognized and assessed. Nevertheless, there are still ongoing limitations in anatomy teaching. Substantial problems consist of diminished allotted dissection time and the number of qualified anatomy instructors, which will eventually deteriorate the quality of education. Alternative resources and strategies are discussed in an attempt to tackle these genuine concerns. The challenges are to reinstate more effective teaching and learning tools while maintaining the beneficial values of orthodox dissection. The UK has a reputable medical education but its quality could be improved by observing international frameworks. The heavy penalty of not concentrating on sufficient anatomy education will inevitably lead to incompetent anatomists and healthcare professionals, leaving patients to face dire repercussions. Anat Sci Educ 3: 83–93, 2010. © 2010 American Association of Anatomists. 相似文献
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Hardik Dodiya Amit Patel Dipal Patel Ashish Kaushal D. G. Vijay 《Indian journal of clinical biochemistry : IJCB》2013,28(4):403-409
The objective of study was to evaluate and correlate the pathological characteristics of breast cancer patients with estrogen receptor (ER), progesterone receptor (PR) and human epidermal growth factor receptor 2 (Her2/neu) detected by immunohistochemistry and/or fluorescent in situ hybridization method. We have conducted 2 year study of 204 cases of breast cancer at HCG-Medisurge Hospitals, Ahmedabad from 2009 to 2011. Significant correlation was found in ER and PR expression whereas no correlation was found in hormonal receptors and Her2/neu expression. ER and PR positivity increased with advancing age in breast carcinoma patients while not affecting Her2/neu expression. The expression of hormone receptors were higher in infiltrating lobular carcinoma and infiltrating duct carcinoma subtypes of breast carcinoma as compared to other subtypes such medullary and in situ carcinoma. High-grade carcinoma patients were predominantly ER/PR negative and Her2/neu positive as compared to lower grade breast carcinoma whereas high-stage carcinoma patients were ER/PR positive and Her2/neu positive as compared to lower stage breast carcinoma. 相似文献
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The centrality of communication in health promotion is described in Healthy People 2010: Objectives for Improving Health, which noted that "health communication can contribute to all aspects of disease prevention and health promotion." In this paper we build on this argument by suggesting that communication science can be advanced by pursuing a "big-science" strategy where important and challenging questions about the role of communication in modern life are studied through rigorous research designs and research findings are applied to addressing significant social issues and problems. A significant dimension of a "big-science" strategy is the pursuit of programs of research using longitudinal designs and large samples with adequate controls. Given that such large-scale studies necessarily involve funding, we review some major funding initiatives and programs in different agencies of the federal governmental. 相似文献
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Viswanath P. Kurup Banani Banerjee Kevin J. Kelly Jordan N. Fink 《Indian journal of clinical biochemistry : IJCB》2000,15(1):31-42
Fungi are non-chlorophyllus microorganisms, which constitutes the main source of outdoor and indoor allergens. The antigens present in the spores and fragments of hyphae induce allergic responses in sensitized patients. The frequently recognized fungi associated with asthma include Alternaria, Cladosporium, Aspergillus, and Penicillium. With the advent of molecular biology techniques a number of fungal genes encoding relevant allergens have been cloned and the expressed allergens purified and characterized. In this review, we have presented the recent developments, where recombinant allergens have been used in the precise diagnosis of fungal allergy. We have also discussed the role played by these allergens and the T- and B-cell epitopes in the immune mechanism in fungal allergy. 相似文献
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