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Yiyu Cai Ruby Chiew Zin Tun Nay Chandrasekaran Indhumathi Lihui Huang 《Interactive Learning Environments》2017,25(8):1098-1109
Basic social interaction and executing certain tasks can be difficult for children with autism spectrum disorder (ASD). The symptoms of such behaviour include inappropriate gestures, body language and facial expressions, lack of interest in certain tasks, cognitive disability in coordination of limbs, and a difficulty in comprehending tasks’ requirements. This paper will discuss our efforts to develop virtual learning environments for children with ASD to improve their gestures and their interests in comprehending tasks’ requirements. Virtual environments are ideal for imparting skills necessary for independence before encouraging children with ASD to try these out in the real world and gain real-life experience. A high-end solution and a simplified solution will be presented together with a discussion on their comparison study. 相似文献
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On 5th October 2005, The Royal Swedish Academy of Sciences decided to award the Nobel Prize in Chemistry for 2005 jointly
to Yves Chauvin, Institute of French Petroleum, France, Robert H Grubbs, California Institute of Technology, USA and Richard
R Schrock, Massachusetts Institute of Technology, USA for the development of the metathesis method in organic synthesis. This
increasingly important organic process allows researchers to synthesize certain kinds of complex molecules that were previously
difficult and inefficient to make. Their research has opened the door to faster and more efficient methods for developing
new drugs and polymers. Imagination will soon be the only limit to what molecules can be built in the laboratory! 相似文献
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Arvind Chandrasekaran Shanmugasundaram Pakkiriswami Jian Liang You Ashwin Acharya Muthukumaran Packirisamy Denis Maxwell 《Biomicrofluidics》2008,2(3)
90 kDa heat shock protein (HSP90) is a ubiquitous molecular chaperone and is one of the abundant proteins present in a cell under normal and stressed conditions. The adenosine triphosphate (ATP) binding region of HSP90 is currently under a great degree of study because of the interest of its role in cancer and protein maintenance; the binding of ATP to HSP90 induces a large conformational change in the protein as a result of the activity of different types of stressors within the cells. In the present paper, a simple microfluidic biosensor is proposed for the characterization of ATP-HSP90 interactions through the principle of bioresistive variation. The experimental results prove that the present biosensor system is highly suitable for the detection of heat shock proteins present in a real-time biological sample, which is very useful for in-situ biomedical applications and rapid pathogenic detections. 相似文献
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Sreenivasulu Reddy Mogali Ramya Chandrasekaran Shairah Radzi Zhen Kai Peh Gerald Jit Shen Tan Preman Rajalingam Wai Yee Yeong 《Anatomical sciences education》2022,15(6):1007-1017
Three-dimensional printing (3DP) technology has been increasingly applied in health profession education. Yet, 3DP anatomical models compared with the plastinated specimens as learning scaffolds are unclear. A randomized-controlled crossover study was used to evaluate the objective outcomes of 3DP models compared with the plastinated specimens through an introductory lecture and team study for learning relatively simple (cardiac) and complex (neck) anatomies. Given the novel multimaterial and multicolored 3DP models are replicas of the plastinated specimens, it is hypothesized that 3DP models have the same educational benefits to plastinated specimens. This study was conducted in two phases in which participants were randomly assigned to 3DP (n = 31) and plastinated cardiac groups (n = 32) in the first phase, whereas same groups (3DP, n = 15; plastinated, n = 18) used switched materials in the second phase for learning neck anatomy. The pretest, educational activities and posttest were conducted for each phase. Miller's framework was used to assess the cognitive outcomes. There was a significant improvement in students' baseline knowledge by 29.7% and 31.3% for Phase 1; 31.7% and 31.3% for Phase 2 plastinated and 3DP models. Posttest scores for cardiac (plastinated, 3DP mean ± SD: 57.0 ± 13.3 and 60.8 ± 13.6, P = 0.27) and neck (70.3 ± 15.6 and 68.3 ± 9.9, P = 0.68) phases showed no significant difference. In addition, no difference observed when cognitive domains compared for both cases. These results reflect that introductory lecture plus either the plastinated or 3DP modes were effective for learning cardiac and neck anatomy. 相似文献
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M. Kumaran D. Deboral Vimala V.S. Chandrasekaran M. Alagappan S. Raja 《The Journal of Agricultural Education and Extension》2013,19(3):247-267
Abstract Purpose: Public-funded fisheries extension services have been blamed as poor and responsible for the slow pace of aquaculture development in India. The present investigation aimed to find concrete interventions to streamline the extension service by understanding the research-extension-farmer linkage indirectly in terms of information sources of aqua farmers and fishery extension officers and assessing the existing organizational, manpower and extension capabilities of Departments of Fisheries of sample states. Design/methodology/approach: A random sample of 1008 brackishwater aqua farmers, a purposive random sample of 60 extension personnel and 45 researchers were interviewed to collect primary data for the study. A multidimensional Organizational Analysis Index was developed specifically for the study. The Wilcoxon paired rank test was employed to analyze and compare the perceptions of the fishery extension personnel. Findings: The study revealed that 90% of aqua farmers depend on private extension sources for information; information-seeking by the extension personnel was less than 50%; and less than 50% of the researchers expressed having had consultations with the extension agencies. Results indicated that the respondents differ significantly over the existing and ideal organizational, manpower and extension attributes of the fisheries departments. An extension approach to evolve a National Fisheries and Aquaculture Extension Service (NFAES) to strengthen fisheries departments with structural and functional realignments and partnership with farm leaders and fisheries professionals is suggested in order to streamline the fisheries and aquaculture extension service in India. Practical implications: The findings of the study may enlighten the fisheries development planners and provide indications to initiate attempts to streamline the fisheries extension departments for an effective extension service in India. Originality/value: The study was originally conducted by the authors. Nothing similar has been previously published or is currently under consideration for publication by another journal. 相似文献
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Nalini Ganesan Hariprasad Chegu A. N. Chandrasekaran 《Indian journal of clinical biochemistry : IJCB》2003,18(2):216-222
Adjuvant induced arthritis (AIA) is a model widely used to study Rheumatoid arthritis (RA). In the present study, lipid peroxides
level in spleen and thymus of AIA rats was observed to be significantly high compared to normal rats. A significant decrease
in ascorbic acid (ASA), reduced glutathione (GSH), superoxide dismutase activity (SOD) was also observed in spleen and thymus
of AIA rats compared to normal rats. There was also a steady increase in the circulating immune complex level (CIC) throughout
the experimental period in serum of AIA rats. In the present investigation, it was decided to study the effect of pre and
post treatment with TYPE II collagen on the antioxidant status and the circulating immune complex level in AIA rats. The results
from the present work indicates that the pretreatment with TYPE II collagen was effective in bringing significant changes
on all the parameters studied in AIA rats. The post treatment with TYPE II collagen was effective in bringing significant
changes on the CIC immune complex level and GSH content in the thymus tissue of AIA rats. The present work suggests that the
pre treatment with TYPE II collagen was more effective in suppressing the disease than the post treatment. 相似文献
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Ramya Chandrasekaran Shairah Radzi Peh Zhen Kai Preman Rajalingam Jerome Rotgans Sreenivasulu Reddy Mogali 《Anatomical sciences education》2022,15(5):850-862
Due to the modernization of the medical curriculum and technological advancements, anatomy education has evolved beyond cadaveric dissection alone. Plastination techniques, three-dimensional (3D) modeling, and 3D printing technologies have progressively gained importance. However, there are limited valid and reliable surveys to evaluate students' perceptions of these new anatomy tools. Hence, this study aimed to develop a validated instrument to measure students' learning satisfaction, self-efficacy, humanistic values, and perceived limitations of plastinated and 3D printed models. A 41-item survey (five-point Likert scale, 1 = strongly disagree to 5 = strongly agree) was administered to Year 1 undergraduate medical students following a randomized controlled crossover study that evaluated plastinated and 3D printed cardiac and neck models. Ninety-six responses were received, and a factor analysis was performed with the Kaiser–Meyer–Olkin sampling adequacy of 0.878. The confirmatory factor analysis yielded a 4-factor, 19 items model that had a good fit with the latent constructs of
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