基于二模复杂网络的隐性知识发现方法研究——以潜在药物靶点挖掘为例     

李东巧  陈芳  韩涛  杨艳萍  王学昭  王燕鹏  Cynthia Liu  Yingzhu Li 《图书情报工作》2020,64(21):120-129

[目的/意义] 通过构建二模复杂网络模型，揭示隐藏在海量文献中的隐性知识。[方法/过程] 通过NetworkX复杂网络工具包，依据任意两个节点的共现关系构建二模复杂网络模型；对网络模型中节点的共现关系进行加权，计算网络的拓扑信息并进行AP聚类，提取节点间的直接关系；采用AUC方法对AA、JC、加权改进的wAA和wJC等4种链路预测算法进行评价，遴选出最合适的预测算法，并对复杂网络的隐性关系进行预测分析。[结果/结论] 以潜在药物靶点挖掘为例进行的实证研究结果表明，wAA链路预测算法为最优的链路预测算法；二模复杂网络模型、指标和方法体系在美国化学文摘社数据库中的药物靶点挖掘中具有一定的有效性。下一步计划在其他数据库中或其他研究领域中进行尝试，以进一步验证该模型的通用性和有效性。  相似文献   

Effects of Manipulative Instruction on Solving Area and Perimeter Problems by Students with Learning Disabilities     

Mike Cass  Dennis Cates  Michelle Smith  Cynthia Jackson 《Learning disabilities research & practice》2003,18(2):112-120

Abstract. A multiple baseline design was employed to test the effect of manipulative instruction on the perimeter and area problem‐solving performance of middle and high school students who had been diagnosed with LD in the area of mathematics. Modeling, prompting/guided practice, and independent practice in conjunction with manipulative training were employed to teach both perimeter and area problem‐solving skills. Analysis of data revealed that the students rapidly acquired the problem‐solving‐skills, maintained these skills over a two‐month period, and transferred these skills to a paper and pencil problem‐solving format. This research extends previous findings by revealing that use of concrete manipulatives promotes the long‐term maintenance of skills.  相似文献   

Good High Schools for Students with Disabilities     

Catherine Cobb Morocco  Cynthia Mata Aguilar  Karen Clay  Nancy Brigham  Naomi Zigmond 《Learning disabilities research & practice》2006,21(3):135-145

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Non-finite loss and challenges to communication between parents and professionals     

Elizabeth Bruce  & Cynthia Schultz 《British Journal of Special Education》2002,29(1):9-13

Elizabeth Bruce PhD, a psychologist in private practice, and Cynthia Schultz PhD, honorary associate at LaTrobe University, both live and work in Australia. Their work on supporting parents who have children with special needs, however, has been published around the world. In this article Bruce and Schultz explore the notion of 'non-finite loss', defined as the ongoing sense of grief experienced by parents caring for children with severe disabilities. The authors discuss the issues that professionals need to consider when working with parents in these circumstances. The article closes with a set of recommendations for promoting more effective partnerships between parents and professionals.  相似文献   

Shared Reading within an Apprenticeship Approach to Reading     

Robin Campbell 《Educational studies》1992,18(2):173-183

Williamson & Carrington argued, in a recent edition of Educational Studies, the need for a major investigation of the effectiveness of an apprenticeship approach to reading. This paper considers some of the problems associated with such investigations. It also seeks to clarify some of the terminology in the whole language repertoire before looking in detail at shared reading as an important part of such approaches. The article concludes by suggesting that ethnographic studies are the means by which issues in the teaching and learning of reading may best be clarified, and teachers and children assisted.  相似文献   

So many filters, so little time: the development of a search filter appraisal checklist          下载免费PDF全文

Julie Glanville  Sue Bayliss  Andrew Booth  Yenal Dundar  Hasina Fernandes  Nigel David Fleeman  Louise Foster  Cynthia Fraser  Anne Fry-Smith  Su Golder  Carol Lefebvre  Caroline Miller  Suzy Paisley  Liz Payne  Alison Price    Karen Welch 《Medical Library and Historical Journal》2008,96(4):356-361

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A Lesson Learned as a Teacher's Helper     

Cynthia Northington Purdie 《Multicultural Perspectives》2014,16(2):110-112

The practice of paddling students for misbehavior remains legal in 19 states. The practice was quite prevalent in the mid- to late-20th century and was implemented in order to instill fear in students, so that they would behave properly. To public school students, this was as normal as recess. To an observer with no former frame of reference, however, it provided a gateway to a greater understanding of discipline, compliance, and classroom management.  相似文献   

Postural stability,clicker reaction time and bow draw force predict performance in elite recurve archery     

Wayne Spratford  Rhiannon Campbell 《European Journal of Sport Science》2017,17(5):539-545

Recurve archery is an Olympic sport that requires extreme precision, upper body strength and endurance. The purpose of this research was to quantify how postural stability variables both pre- and post-arrow release, draw force, flight time, arrow length and clicker reaction time, collectively, impacted on the performance or scoring outcomes in elite recurve archery athletes. Thirty-nine elite-level recurve archers (23 male and 16 female; mean age?=?24.7?±?7.3 years) from four different countries volunteered to participate in this study prior to competing at a World Cup event. An AMTI force platform (1000Hz) was used to obtain centre of pressure (COP) measurements 1s prior to arrow release and 0.5s post-arrow release. High-speed footage (200Hz) allowed for calculation of arrow flight time and score. Results identified clicker reaction time, draw force and maximum sway speed as the variables that best predicted shot performance. Specifically, reduced clicker reaction time, greater bow draw force and reduced postural sway speed post-arrow release were predictors of higher scoring shots. It is suggested that future research should focus on investigating shoulder muscle tremors at full draw in relation to clicker reaction time, and the effect of upper body strength interventions (specifically targeting the musculature around the shoulder girdle) on performance in recurve archers.  相似文献   

A new (old)anatomy     

Cynthia Klestinec  Gideon Manning 《Metascience》2015,24(1):65-69

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Chronicling the West for “Harper's”: Coast to Coast with Frenzeny & Tavernier in 1873–1874 Claudine Chalmers. Norman: University of Oklahoma Press, 2013.          下载免费PDF全文

Cynthia Lee Patterson 《Journal of American culture (Malden, Mass. : 2003)》2015,38(2):156-157

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