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Serge Herve Tiyong Ifoue C. Teugwa Mofor I. Gouado G. Teto T. Asonganyi P. H. Amvam Zollo 《Indian journal of clinical biochemistry : IJCB》2009,24(3):288-293
Oxidative stress is thought to be involved in the pathophysiology of malaria, especially in pregnancy where natural resistance
is markedly reduced. In the present study we investigated oxidative stress in 315 pregnant women out of which 159 had Plasmodium
falciparum malaria and 154 controls. We evaluated the level of lipid peroxidation products (MDA level) in the plasma, the
activity of erythrocyte antioxidant defense enzymes, superoxide dismutase (SOD, EC: 1.15.1.1) and catalase (Cat, EC: 1.11.1.6)
as well as the ability to resist oxidative stress by the FRAP (Ferric Reducing Ability of Plasma) assay. Total erythrocyte
protein levels were also examined. For the two groups of patients, several differences between the biochemical parameters
tested were found. Median parasitaemia in women with malaria was 25,392 parasites/μl of blood (Range1200–82000), while in
controls we had no parasites found in thin and thick smears. Levels of lipid peroxidation products (MDA) were significantly
higher in patients with parasitemia than in healthy asymptomatic volunteers (mean: 0.844 ± 0.290 and 0.384 ± 0.129 respectively,
p<0.001). This MDA level was higher in primigravidea and also correlates well with parasite density (p<0.001). Catalase activity
in erythrocytes of women with malaria did not differ statistically from that of controls. In contrast, SOD activity of patients
with malaria was found to be significantly higher than that of controls (mean: 0.7899 ± 0.2777 and 0.4263 ± 0.2629 respectively,
p<0.05). FRAP values declined, from parasitemic patients (1.4619 ± 0.6565) compare to controls (2.4396 ± 0.8883, p<0.05),
particularly in the first and third trimester of gestation (p<0.05 and p<0.01 respectively). Finally, total erythrocyte protein
concentrations of women with malaria did not differ from that of the controls. Our results suggest an imbalance between oxidants
and antioxidants in pregnant women suffering from malaria, a situation which could lead to severe damage for either the mother
or the fetus. Therefore, further research should be done to assess the potential benefits of antioxidant supplementation for
the pregnant women suffering from malaria. 相似文献
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The goal of this investigation was to analyze the impact of some production variables (input) on agricultural productivity growth (output) in China from 1989～2002. We selected through random sampling Zhejiang Province for our disaggregate analysis with the use of Cobb-Douglas function. The estimation results showed that all key parameters are significant and are of the expected sign. Labor and that capital and land have positive impact on agricultural productivity growth. 相似文献
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The goal of this investigation was to analyze the impact of some production variables （input） on agricultural productivity growth （output） in China from 1989-2002. We selected through random sampling Zhejiang Province for our disaggregate analysis with the use of Cobb-Douglas function. The estimation results showed that all key parameters are significant and are of the expected sign. Labor and that capital and land have positive impact on agricultural productivity growth. 相似文献
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