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Classroom     
In this section of Resonance, we invite readers to pose questions likely to be raised in a classroom situation. Wemay suggest strategies for dealingwith them, or invite responses, or both. “Classroom” is equally a forum for raising broader issues and sharing personal experiences and viewpoints on matters related to teaching and learning science.  相似文献   
2.
Cultural Studies of Science Education - The M(East) ward of Mumbai is home to one of Asia’s largest open landfill sites. Waste, therefore, is a source of livelihood for millions of people...  相似文献   
3.

This article is a response to María del Mar Aragón, José Antonio Acevedo-Díaz and Antonio García-Carmona’s article, which investigated pre-service teachers’ understandings of epistemic and non-epistemic aspects of the nature of science (NOS) based on the historical case study of Ignaz Semmelweis and childbed fever. We situate the study in contemporary mainstream debates on teaching NOS and argue that science educators ought to focus on conveying specific aspects of NOS in-depth, instead of covering a general check list of NOS tenets in their classrooms. Furthermore, we argue that there are multiple ways of narrating the story of science, the protagonist of science classrooms, and that educators should also be conscious of the metanarratives regarding science that get conveyed in their narratives.

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Bardet-Biedl syndrome (BBS) is a rare autosomal recessive condition characterized by retinitis pigmentosa, postaxial polydactyly, central obesity, and renal involvement. Renal failure is the commonest cause of death. We report a case of BBS with chronic kidney disease (CKD) at younger age (17 year) from India. This diagnosis should be considered in patients with renal disease and the characteristic phenotype of retinitis pigmentosa, postaxial polydactyly and central obesity. These patients should undergo regular monitoring of renal function test to early diagnosis and treatment of CKD to prevent morbidity and mortality. Renal transplantation is a viable option of renal replacement therapy in these patients. These findings are valuable for comparing phenotype of BBS patients with CKD from various national and international centers.  相似文献   
5.
Down syndrome is one of the most common genetic causes of learning disabilities in children. Although the incidence of renal and urological involvement in Down syndrome is not very common, monitoring of patients with Down syndrome for renal diseases should be done regularly as patient’s age into the second and third decades. With increased survival, it appears that a growing number of these patients present with chronic renal failure. Down syndrome patients are apparently not suited for peritoneal dialysis because of lacking cooperation. This procedure can be prone to failure, mainly because of an increased risk of peritonitis. Handling such patients especially those on peritoneal dialysis is challenging. Here we report a case of Down syndrome with end-stage renal disease treated with hemodialysis for 6 months. To the best of our knowledge and current literature review this is the first case report of a patient with Down syndrome undergoing hemodialysis.  相似文献   
6.
Programs for geospatial support at academic libraries have evolved over the past decade in response to changing campus needs and developing technologies. Geospatial applications have matured tremendously in this time, emerging from specialty tools to become broadly used across numerous disciplines. At many universities, the library has served as a central resource allowing students and faculty across academic departments access to GIS resources. Today, as many academic libraries evaluate their spaces and services, GIS and data services are central in discussions on how to further engage with patrons and meet increasingly diverse researcher needs. As library programs evolve to support increasingly technical data and GIS needs, many universities are faced with similar challenges and opportunities. To explore these themes, data and GIS services librarians and GIS specialists from five universities—the University of North Carolina at Chapel Hill, Texas A&M, New York University, North Carolina State University, and California Polytechnic State University—with different models of library geospatial and data support, describe their programs to help identify common services, as well as unique challenges, opportunities, and future plans.  相似文献   
7.
Single nucleotide polymorphisms in CYP3A5 (A6986G) and MDR-1 (C3435T) genes have been shown to be associated with the pharmacokinetics of tacrolimus in case of renal transplant recipients. Knowing these genotypes of the recipients before undergoing transplantation, is therefore essential for physicians to adjust the starting dose of tacrolimus in order to avoid drug induced nephrotoxicity. We have designed an allele specific PCR method for easier and rapid detection of these polymorphisms. 20 Indian renal transplant recipients on tacrolimus who developed nephrotoxicity within 1 month of transplantation and 58 Indian non-transplant subjects having the risk factors for kidney disease i.e. hypertension or diabetes or the family history of these, have been studied for these SNPs by allele specific PCR method. The data suggest that the heterozygosity of CYP3A5 and mutant allele frequency of MDR-1 SNP is higher in transplant patients as well as in general population.  相似文献   
8.
In this paper, we use a spiral channel inertial focusing device for isolation and purification of chromosomes, which are highly asymmetric. The method developed is proposed as a sample preparation process for transchromosomic research. The proposed microfluidics-based chromosome separation approach enables rapid, label-free isolation of bioactive chromosomes and is compatible with chromosome buffer. As part of this work, particle force analysis during the separation process is performed utilizing mathematic models to estimate the expected behavior of chromosomes in the channel and the model validated with experiments employing fluorescent beads. The chromosome sample is further divided into subtypes utilizing fluorescent activated cell sorting , including small condensed chromosomes, single chromosomes, and groups of two chromosomes (four sister chromatids). The separation of chromosome subtypes is realized based on their shape differences in the spiral channel device under high flow rate conditions. When chromosomes become aligned in the shear flow, the balance between the inertial focusing force and the Dean flow drag force is determined by the chromosome projection area and aspect ratio, or shape difference, leading to different focusing locations in the channel. The achieved results indicate a new separation regime in inertial microfluidics that can be used for the separation of non-spherical particles based on particle aspect ratios, which could potentially be applied in fields such as bacteria subtype separation and chromosome karyotyping.  相似文献   
9.
Abstract

This study consists of two interdependent parts. First we categorise the environmental philosophies prevalent amongst environmentalists in India by comparing the way the environmental crisis is understood and what its causes and solutions are thought to be. In the second part, we use this categorisation for a case study of three high school science teachers in Indore, Madhya Pradesh. Our aim is to find out what environmental philosophies underlay their teaching. In order to do this, we collected data by interviewing the teachers, observing their classrooms, and studying their textbooks. We then looked through our data for indications of the environmental philosophies found in part 1. Although the interviews showed some signs of Gandhian, Appropriate Technology, Eco-marxist, and other philosophies, in the classrooms the teachers adhered mainly to Ecological Modernisation and Eco-capitalist philosophies, and rarely expressed their own opinions. Despite progressive policy statements, the teaching was mainly textbook based, neglecting to consider systemic causes or solutions. One of the most significant findings was the prevalence of an idealist faith in a ‘Balance of Nature’ which was trusted to rectify upsets caused by human immorality.  相似文献   
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