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1.
Wojciech Szczęsny Magdalena Kuligowska-Prusińska Stanisław Dąbrowiecki Jakub Szmytkowski Adrian Reśliński Maciej Słupski 《Journal of Zhejiang University. Science. B》2018,19(1):65-70
Purpose
Metalloproteinases are a key component of the pathogenesis of abdominal hernias. Obesity is considered a risk factor in herniogenesis and hernia recurrence. The aim of this study was to evaluate the serum concentrations of metalloproteinase-2 (MMP-2), MMP-9, MMP-13, and adiponectin in morbidly obese and nonoverweight controls.Materials and methods
The participants were recruited from among patients undergoing bariatric and non-bariatric surgery and divided into two groups: I (body mass index (BMI)≥35 kg/m2, n=40) and II (BMI<25 kg/m2, n=30). Serum concentrations of MMP-2, MMP-9, MMP-13, and adiponectin were measured using enzyme-linked immunosorbent assay (ELISA).Results
A statistically significant difference between groups was observed for MMP-2 concentration. The median MMP-9 concentration was higher in the obese group, but the difference was not statistically significant. Median MMP-13 concentrations did not differ between groups. Serum adiponectin concentration was insignificantly higher in the non-obese group.Conclusions
The elevated serum MMP-2 and MMP-9 concentrations in obese individuals may be related to the higher incidence of incisional hernias in this population.2.
A seven channel polystyrene (PS) microchip has been constructed using a micromilling machine and a high-temperature assembling. Protein A (PA) has been immobilized by a passive sorption on the microchannel walls. Two bioaffinity assays with human immunoglobulin G (hIgG) as a ligand have been carried out. (i) PA as the receptor and fluorescently labeled hIgG (FITC-hIgG) as the ligand, (ii) PA as the receptor with hIgG as the quantified ligand and fluorescently labeled goat anti-human IgG (FITC-gIgG) as the secondary ligand. One incubation step of the assays took only 5 min instead of hours typical for enzyme-linked immunosorbent assay applications. Calibration curves of the dependence of a fluorescence signal on the hIgG concentration in a sample have been obtained in one step due to a parallel arrangement of microchannels. A mathematical model of the PA-FITC-hIgG complex formation in the chip has been developed. The values of the kinetic constant of the PA-FITC-hIgG binding (kon=5.5 m3 mol−1 s−1) and the equilibrium dissociation constant of the formed complex (Kd≤3×10−6 mol m−3) have been obtained by fitting to experimental data. The proposed microchip enables fast evaluation of kinetic and equilibrium constants of ligand-receptor bioaffinity pairs and the ligand quantification. As the use of microfluidic chips for immunoassays is often limited by price, we used procedures and chemicals that allow for an inexpensive construction and operation of the microdevice, e.g., temperature assembling as a fabrication technique, detection via an ordinary digital camera, nonspecific polystyrene as a substrate, passive sorption of biomolecules as an immobilization technique, etc. 相似文献
3.
On knowledge-poor methods for person name matching and lemmatization for highly inflectional languages 总被引：1，自引：1，他引：0
Web person search is one of the most common activities of Internet users. Recently, a vast amount of work on applying various
NLP techniques for person name disambiguation in large web document collections has been reported, where the main focus was
on English and few other major languages. This article reports on knowledge-poor methods for tackling person name matching
and lemmatization in Polish, a highly inflectional language with complex person name declension paradigm. These methods apply
mainly well-established string distance metrics, some new variants thereof, automatically acquired simple suffix-based lemmatization
patterns and some combinations of the aforementioned techniques. Furthermore, we also carried out some initial experiments
on deploying techniques that utilize the context, in which person names appear. Results of numerous experiments are presented.
The evaluation carried out on a data set extracted from a corpus of on-line news articles revealed that achieving lemmatization
accuracy figures greater than 90% seems to be difficult, whereas combining string distance metrics with suffix-based patterns
results in 97.6–99% accuracy for the name matching task. Interestingly, no significant additional gain could be achieved through
integrating some basic techniques, which try to exploit the local context the names appear in. Although our explorations were
focused on Polish, we believe that the work presented in this article constitutes practical guidelines for tackling the same
problem for other highly inflectional languages with similar phenomena.
相似文献
| Marcin SydowEmail: |
4.
This article shows how the probability of enrolment in tertiary schools has evolved for different social groups in Poland during the period of the educational boom. It also analyses how the socio-economic status influences the choices between full-time and part-time studies (the latter being of relatively low quality), and the probability of admission to subsidised, free programmes versus programmes with tuition fees. Between 1994 and 2008, Poland improved the participation of students with a low socio-economic status in university education. However, if we look at the change in the ratios of enrolment probabilities for different layers of the social strata, we find that the improvement refers to those with a low family educational background who live in small cities, but not to those from low income families. Further investigation shows that the policy makers should focus not only on ensuring equal access to tertiary education for all social strata, but on allowing the unprivileged groups access to education of acceptable quality. 相似文献
5.
The question is whether or not we or any student are allowed to define a measure of variability in some other way that is not written in textbooks and officially approved. We compare the sum of squares of all deviations against the usual sum of squares of deviations from the mean. 相似文献
6.
Science & Education - In this paper, we explored the scientific literacy of a general sample of the Slovak adult population and examined factors that might help or inhibit scientific reasoning,... 相似文献
7.
Jakub Hladik 《Multicultural Perspectives》2016,18(1):42-47
In this article, I focus on assessing multicultural competence of helping-profession students. The Multicultural Competence Scale of Helping-Profession Students was used for data collection. The aim of the research was to find out the level of students' multicultural competence due to the current lack of this information in Central Europe. Generally, students assess their multicultural competence on the higher level. There is a significant relationship between the students' study degree and the level of their multicultural competence. Multicultural activity was shown as an important predictor of multicultural knowledge. Also, multicultural knowledge was identified as a significant predictor of multicultural communication skills. 相似文献
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9.
Day A Campbell I Clelland D Doctors LJ Cichowicz J 《Journal of sports sciences》2011,29(10):1059-1069
In this study, we investigated the effect of hull dynamics in shallow water on the hydrodynamic performance of rowing shells as well as canoes and kayaks. An approach was developed to generate data in a towing tank using a test rig capable of reproducing realistic speed profiles. The impact of unsteady shallow-water effects on wave-making resistance was examined via experimental measurements on a benchmark hull. The data generated were used to explore the validity of a computational approach developed to predict unsteady shallow-water wave resistance. Comparison of measured and predicted results showed that the computational approach correctly predicted complex unsteady wave-resistance phenomena at low oscillation frequency and speed, but that total resistance was substantially under-predicted at moderate oscillation frequency and speed. It was postulated that this discrepancy arose from unsteady viscous effects. This was investigated via hot-film measurements for a full-scale single scull in unsteady flow in both towing-tank and field-trial conditions. Results suggested a strong link between acceleration and turbulence and demonstrated that the measured real-world viscous-flow behaviour could be successfully reproduced in the tank. Thus a suitable tank-test approach could provide a reliable guide to hull performance characterization in unsteady flow. 相似文献
10.