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The aims of this study were to examine the changes in plasma concentrations of inflammatory cytokines induced by training and competition in professional cyclists. We report the serum concentrations of interleukin-6 (IL-6), tumour necrosis factor alpha (TNF-a), tumour necrosis factor receptors I and II (TNFR-I and -II) in a prospective, randomized, double-blind trial involving the administration of AM3 (Inmunoferon), an oral booster immunomodulator, or placebo to 16 professional cyclists (n = 8 in each group) for 65 consecutive days. Serum was collected just before treatment began (baseline), at the end of pre-competition training, before the mountain stage of the competition (60 days), 4 h after finishing this stage (62 days), and 18 h after the fifth and last day of competition (65 days). To determine the normal levels of cytokines and soluble TNF receptors, individual samples from 14 moderately trained healthy controls were studied. After 60 days of training, the serum concentrations of IL-6 did not differ significantly from those at the beginning of the study for either group of cyclists (placebo and AM3). A significant rise was seen in IL-6 concentrations in both the AM3 and placebo groups at 62 days, 4 h after finishing the mountain stage. The increase was significantly greater in the placebo group than in the AM3 group. At 65 days of treatment, 18 h after the fifth and last day of competition, IL-6 concentrations were similar to those recorded at the end of the training, but were significantly higher in the placebo group than in the AM3 group. At the end of training, serum TNFR-I concentrations in both groups of cyclists were significantly lower than at baseline. The concentrations of serum TNFR-I and -II both 4 h after finishing the mountain stage and 18 h after the fifth and last day of competition were significantly higher than those recorded after training in both groups. Professional cycling competition is associated with increases in serum IL-6 and TNFR-I and -II concentrations. Inmunoferon treatment reduced significantly the concentrations of IL-6 but not those of TNFR-I and -II. 相似文献
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Rodolfo herrero Ricaño Héctor Barrón Soto 《The American journal of distance education》2013,27(1):68-71
Abstract Since 1947, distance education in Mexico has had an important role for nonconventional populations. Considering that distance education is a heterogeneous and dynamic field, it is important to reflect on the need to improve quality as measured by our own standards. With that perspective in mind, a national meeting was organized to start a self‐diagnosis in which quality and access were the main concerns. Five hundred and twenty specialists from fifty‐one institutions participated in a national interactive synchronous meeting held in four regions. As a result of the meeting, thirty‐five criteria and 230 parameters of quality were established. The main conclusion of the meeting refers to the need for the elaboration of our own indicators for open and distance education. 相似文献
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Teachers' written reflections on their work, which report on a change in their practice, were the object of this research. Taking teachers' articulation of their plans and actions in teacher journals as our source, this study's aim is twofold: (1) to describe how teacher reflect in a self‐initiated and non‐framed way on their own practice, and (2) to review teacher self generated reflections in reference to models of reflection. In this way, we tried to disclose what precisely teachers write (said) when reflecting on their work (did) in order to appreciate their way of describing what matters in their work; and position this in reference to models that conceptualise (“talk”) on how to actualise (‘walk’) reflection. This ‘double’ articulation of reflection is gauged in two ways, i.e., on: a) completeness, that is, whether it includes relevant components of reflection (models) to be found in the literature, and on b) recursiveness, that is, whether the written account gives evidence of an integrated cyclical, i.e., recursive process of re‐view, which appraises and looks back on what has been accomplished. The results show that teachers do not work along the lines identified in current reflection models (i.e. providing clear problem definition, searching for evidence, planning for change, and reviewing plans). Instead, many teachers use a narrative and valuing appraisal of their accomplishments; not so much cautiously reviewing their actions but prospectively commenting on plans and solutions for future action. The data lead us to be cautious about the prominence of reflection models as advocated in the literature to be applied to teachers' written accounts of their practice. 相似文献
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Mary Esther Soto Huerta 《Journal of Latinos & Education》2017,16(3):192-202
This study contributes to the limited research on emergent bilinguals, perspective taking, and second language reading of informative text. The explicit integration of Freire’s (1993) notion of conscientizacao, or consciousness-raising, with the constructs of empathy and embodiment (Gee, 2001; Hurtado, 1996) and with translanguaging (García, 2009) represented conceptual frameworks that explicitly guided the pedagogical approaches implemented in the study. The findings indicated that the incorporation of the integrated conceptual frameworks with the prescribed fourth grade social studies curriculum enabled emergent bilinguals to generate their own perspectives concerning social justice and equity when studying about slavery in Texas. 相似文献
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Tae Kyoung Lee Alan Meca Jennifer B. Unger Byron L. Zamboanga Lourdes Baezconde-Garbanati Melinda Gonzales-Backen Elma I. Lorenzo-Blanco Miguel Á. Cano Sabrina E. Des Rosiers Daniel W. Soto Juan A. Villamar Monica Pattarroyo Karina M. Lizzi José Szapocznik Seth J. Schwartz 《Child development》2020,91(1):78-95
Acculturation consists of multiple domains (i.e., cultural practices, identifications, and values). However, less is known about how acculturation processes influence each other across multiple domains of acculturation. This study was designed to investigate transition patterns of acculturative processes within and across domains in a sample of 302 recent-immigrant Hispanic adolescents, Mage (SD) = 14.51 years (0.88) at baseline; male = 53%). Adolescents were assessed six times over a 3-year period. Latent profile analyses identified two profiles (high [or increasing] vs. low) for each domain at each timepoint. We found largely stable transition patterns in each domain over six timepoints. Importantly, sequential associations among profiles in acculturation domains were also detected. Implication for acculturation theory and research are discussed. 相似文献
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Students’ perceptions of engineering have been documented through studies involving interviews, surveys, and word associations
that take a direct approach to asking students about various aspects of their understanding of engineering. Research on perceptions
of engineering rarely focuses on how students would portray engineering to others. First-year engineering student teams proposed
a museum exhibit, targeted to middle school students, to explore the question “What is engineering?” The proposals took the
form of a poster. The overarching research question focuses on how these students would portray engineering to middle school
students as seen through their museum exhibit proposals. A preliminary analysis was done on 357 posters to determine the overall
engineering themes for the proposed museum exhibits. Forty of these posters were selected and, using open coding, more thoroughly
analyzed to learn what artifacts/objects, concepts, and skills student teams associate with engineering. These posters were
also analyzed to determine if there were any differences by gender composition of the student teams. Building, designing,
and teamwork are skills the first-year engineering students link to engineering. Regarding artifacts, students mentioned those
related to transportation and structures most often. All-male teams were more likely to focus on the idea of space and to
mention teamwork and designing as engineering skills; equal-gender teams were more likely to focus on the multidisciplinary
aspect of engineering. This analysis of student teams’ proposals provides baseline data, positioning instructors to develop
and assess instructional interventions that stretch students’ self-exploration of engineering. 相似文献
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This article outlines the preliminary findings from a small scale research project set up by a group of UKRA members to monitor teachers’ views of the literacy hour in its first year. The research draws on questionnaires, interviews and video data to reveal issues which concerned those teachers taking part in the survey and provides a snapshot of what it was like for some teachers coping with this initiative. 相似文献
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Rainer Simon Elton Barker Leif Isaksen Pau De Soto CaÑamares 《Journal of Map & Geography Libraries》2017,13(1):111-132
Recogito 2 is an open source annotation tool currently under development by Pelagios, an international initiative aimed at facilitating better linkages between online resources documenting the past. With Recogito 2, we aim to provide an environment for efficient semantic annotation—i.e., the task of enriching content with references to controlled vocabularies—in order to facilitate links between online data. At the same time, we address a perceived gap in the performance of existing tools, by emphasizing the development of mechanisms for manual intervention and editorial control that support the curation of quality data. While Recogito 2 provides an online workspace for general-purpose document annotation, it is particularly well-suited for geo-annotation, in other words annotating documents with references to gazetteers, and supports the annotation of both texts and images (i.e., digitized maps). Already available for testing at http://recogito.pelagios.org, its formal release to the public occurred in December 2016. 相似文献
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