Interaction of LDL and platelets in ischaemic and ischaemic risk subjects     

Yashika Gupta  V. Mallika  D. K. Srivastava 《Indian journal of clinical biochemistry : IJCB》2005,20(1):87-94

Platelets play a vital role in the progression of atherosclerosis and thrombosis, a major cause of death worldwide. Platelets are activated by many triggers like elevated LDL in blood resulting in aggregation and formation of plaque. The purpose of this study was to investigate the effect of LDL and signal transduction inhibitor on the activation of platelets in Ischaemic risk subjects. Platelets from IHD and hyperlipidemic subjects were hypersensitive to ADP, as higher levels of platelet aggregation were observed in these groups. LDL from IHD hyperlipidemic subjects was more effective in activating platelets from any other group. Ox-LDL was more effective in activating platelets than native-LDL as monitored by level of platelet aggregation induced by PAF and thrombin. Calcium channel blocker, nifedipine and verapamil inhibited platelet aggregation at micromolar level. Protein kinase inhibitor, staurosporine was effective in inhibiting ADP induced aggregation at nanomolar level.  相似文献   

Gödel’s proof     

S M Srivastava 《Resonance》2007,12(2):59-70

In 1931, the great Austrian mathematician Kurt Gödel proved “all consistent axiomatic formulations of number theory include undecidable propositions”. This discovery of Gödel and its proof had enormous repercussions in mathematics and computer science. The proof hinged upon the writing of a self-referential mathematical statement, in the same way as the liar’s paradox — I am lying — is a self-referential statement. In this three-part article, we describe Gödel’s discovery and his famous proof.  相似文献   

Examining the discourse on waste in school education from the standpoint of marginalized communities in Mumbai     

Srivastava  Himanshu  Gupta  Ankush  Raveendran  Aswathy 《Cultural Studies of Science Education》2022,17(2):301-330

Cultural Studies of Science Education - The M(East) ward of Mumbai is home to one of Asia’s largest open landfill sites. Waste, therefore, is a source of livelihood for millions of people...  相似文献   

Some innovative initiatives in literacy,post-literacy and continuing education in Asia     

H. S. Srivastava 《International Review of Education/Internationale Zeitschrift für Erziehungswissenschaft/Revue internationale l'éducation》1985,30(3):369-375

  相似文献   

Why do long‐serving teachers stay in the teaching profession? Analysing the motivations of teachers with 10 or more years’ experience in England          下载免费PDF全文

Charleen Chiong  Loic Menzies  Meenakshi Parameshwaran 《British Educational Research Journal》2017,43(6):1083-1110

This paper examines the reasons why long‐serving teachers remain in the teaching profession. Interest in teacher retention has grown in recent years, both in the UK and internationally, due to concerns over teacher shortage. However, most research on retention has focused on why teachers leave; this paper aims to fill the gap in our understanding of the positive reasons why long‐serving teachers stay in the profession, and how these reasons change over time. We define ‘long‐serving teachers’ as teachers who have taught for 10 years and more. We draw on a subset of data from an existing, broader study (Menzies et al., 2015 ) on why teachers enter and stay in the profession. In this paper, we draw on questionnaire findings from over 900 teachers with 0 to over 30 years’ teaching experience, and interviews with 14 long‐serving teachers, to understand why long‐serving teachers enter and, more importantly for our purposes, stay in teaching. We find that teachers’ motivational patterns are highly complex and influenced by school‐level and policy contexts. Nonetheless, two prominent retention factors are identified: teachers’ perceived professional mastery and altruistic reasons. Perceived professional mastery is particularly important due to its mutually reinforcing analytic relationships with other reasons. We find that teachers’ identification with intrinsic, altruistic and perceived professional mastery reasons become stronger with years of experience, but in some cases, paradoxically, so does their identification with extrinsic reasons. From our evidence, we suggest policy implications for enhancing the retention of long‐serving teachers.  相似文献   

Genetics of Obesity     

Apurva Srivastava  Neena Srivastava  Balraj Mittal 《Indian journal of clinical biochemistry : IJCB》2016,31(4):361-371

Numerous classical genetic studies have proved that genes are contributory factors for obesity. Genes are directly responsible for obesity associated disorders such as Bardet–Biedl and Prader–Willi syndromes. However, both genes as well as environment are associated with obesity in the general population. Genetic epidemiological approaches, particularly genome-wide association studies, have unraveled many genes which play important roles in human obesity. Elucidation of their biological functions can be very useful for understanding pathobiology of obesity. In the near future, further exploration of obesity genetics may help to develop useful diagnostic and predictive tests for obesity treatment.  相似文献   

Hyperhomocysteinemia,MMPs and Cochlear Function: A Short Review     

Seema Bhargava  Meghaa Shanta Bhargava  Eishaan Kamta Bhargava  LM Srivastava 《Indian journal of clinical biochemistry : IJCB》2016,31(2):148-151

Hyperhomocysteinemia (HHCY) has been demonstrated to affect cochlear microvasculature as well as cochlear epithelial cells directly, with a resultant alteration of the expression of matrix metalloproteinases (MMPs) and their inhibitors, tissue inhibitors of metalloproteinases (TIMPs). Hence, ascertaining the optimum concentration of MMPs and TIMPs in the cochlea could help to inhibit hearing loss due to HHCY by the administration of appropriate MMP inhibitors, Since infections/inflammations as well as ototoxic antibiotics have a similar mechanism of otic pathology, the cochlear damage they cause could also be similarly prevented.  相似文献   

Does Felt Gender Compatibility Mediate Influences of Self‐Perceived Gender Nonconformity on Early Adolescents’ Psychosocial Adjustment?     

Menon M 《Child development》2011,82(4):1152-1162

This study evaluated the hypothesis that self-perceived gender nonconformity is distressing to children because it undermines a confident sense of gender compatibility. Participants were 357 early adolescents (180 boys, M age = 12.68 years) in England who responded to questionnaires measuring friendship styles (preoccupied, avoidant), gender compatibility (typicality, contentedness), and adjustment (self-esteem, peer social competence, depression, narcissism). Sex differences in friendship styles indicated that preoccupied and avoidant styles were typical for girls and boys, respectively. Gender-atypical friendship styles predicted poor adjustment, and their impact on adjustment was partially mediated by felt gender compatibility. Results suggest that perceiving gender-atypical attributes in the self undermines adjustment partly because it leads children to feel incompatible with their gender collective.  相似文献   

Individualism-collectivism and business context as predictors of behaviors in cross-national work settings: Incidence and outcomes     

Peter B. Smith  Cláudio V. TorresAlena Chudzikova  Serdar DegirmenciogluFrancisco Donoso-Maluf  Nancy Chen Yi FengCharles Harb  Brad JacksonSigmar Malvezzi  Andrew MogajiJuan Carlos Pastor  Lorena Perez-FlorianoB.N. Srivastava  Günter StahlStephanie Thomason  Vladimir Yanchuk 《Int J Intercult Relat》2011,35(4):440-451

  相似文献   

Serum lipids in dilated cardiomyopathy     

R. L. Tripathi  L. M. Srivastava 《Indian journal of clinical biochemistry : IJCB》1995,10(1):48-49

Serum total cholesterol and triglyceride levels were estimated in 45 dilated cardiomyopathy (DCM) patients and were compared with 31 healthy controls. The total serum cholesterol (215±50 mg/dl) and serum triglyceride (162±76 mg/dl) levels in DCM patients did not show any significant changes as compared to normal controls. The cholesterol and triglyceride and the individual lipoprotein fractions, viz HDL, VLDL, LDL and chylomicrons were analysed in 10 patients. The values did not differ significantly when compared to those of controls. These findings suggest that serum lipids may not play a role in the antietiopathogenesis of DCM.  相似文献