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Luca Lanotte Giovanna Tomaiuolo Chaouqi Misbah Lionel Bureau Stefano Guido 《Biomicrofluidics》2014,8(1)
The confined flow of red blood cells (RBCs) in microvasculature is essential for oxygen delivery to body tissues and has been extensively investigated in the literature, both in vivo and in vitro. One of the main problems still open in microcirculation is that flow resistance in microcapillaries in vivo is higher than that in vitro. This discrepancy has been attributed to the glycocalyx, a macromolecular layer lining the inner walls of vessels in vivo, but no direct experimental evidence of this hypothesis has been provided so far. Here, we investigate the flow behavior of RBCs in glass microcapillaries coated with a polymer brush (referred to as “hairy” microcapillaries as opposed to “bare” ones with no coating), an experimental model system of the glycocalyx. By high-speed microscopy imaging and image analysis, a velocity reduction of RBCs flowing in hairy microcapillaries as compared to bare ones is indeed found at the same pressure drop. Interestingly, such slowing down is larger than expected from lumen reduction due to the polymer brush and displays an on-off trend with a threshold around 70 nm of polymer brush dry thickness. Above this threshold, the presence of the polymer brush is associated with an increased RBC deformation, and RBC velocity is independent on polymer brush thickness (at the same pressure drop). In conclusion, this work provides direct support to the hypothesis that the glycocalyx is the main factor responsible of the higher flow resistance found in microcapillaries in vivo. 相似文献
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Misbah Zainun Gulikers Judith Widhiarso Wahyu Mulder Martin 《Learning Environments Research》2022,25(3):641-661
Learning Environments Research - Studies of connections between teacher behaviour and student outcomes are numerous, but those specifically addressing such connections in a competence-based... 相似文献
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Learning Environments Research - Theory and research in the field of competence-based vocational education (CBVE) have advanced enormously during the last decades, although empirical research on... 相似文献
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Munazza Jabeen Liu Yun Muhammad Rafiq Misbah Jabeen Muhammad Azam Tahir 《International Information and Library Review》2013,45(3-4):71-82
This article highlights the research productivity and scholarly communication of library and information science professionals during 2003–2012 by using Web of Science databases from 40 library and information science core journals. Data was interpreted by using two open-source software Vantage point (powerful text-mining tool for discovering meaningful result from raw data) and CiteSpace II to visualize the library and information science growth and trends. Underlying results indicated that mainstream of authors (12,847, 69.9%) published their article as a single author from 2003–2009, this trend has declined and collaborative number of publications trend has inclined during the last 3 years. The University of Illinois at Urbana-Champaign produced 95 (0.52%) of the total publications and stands at the leading position. The maximum number of publications was carried out by universities rather than non-academic institutions. This article identified that Asian countries, such as China, Taiwan, India, and Iran, are still in its infancy stage. The present study could be considered as a useful tool for effective allocation of research funds in the research community and academic world of library and information science to enhance the research process. 相似文献
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